Enterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance

著者: Qianqian Li, Xuan Sun, Kaiyuan Yu, Junqiang Lv, Chunhui Miao, Jianming Yang, Song Wang, Zheng Fu, Ya-min Sun, Hong Zhang, Zhi‐Song Zhang, Evan T. Keller, Zhi Yao, Quan Wang - Cell Reports 2022 被引用: 43

DC and regulatory T (Treg)-mediated immune tolerance for colitis remission using in vitro and in vivo experiments. Moreover, choline, one metabolite of E. ludwigii, is identified to increase dendritic cells' (DCs) immune tolerance to promote Treg differentiation. E. ludwigii is found to induce DCs' immune tolerance ability for Treg differentiation through choline and α7nAChR-mediated retinoic acid (RA) and transforming growth factor beta (TGF-β) upregulation, resulting in protecting mice against DSS-induced colitis. This study suggests potential therapeutic approaches for inflammatory bowel diseases (IBDs).