Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

著者: Christopher H. Goss, Yukihiro Kaneko, Lisa Khuu, Gail D. Anderson, Sumedha Ravishankar, Moira L. Aitken, Noah Lechtzin, Guolin Zhou, Daniel M. Czyż, Kathryn McLean, Oyebode Olakanmi, Howard A. Shuman, M. Teresi, Ellen Wilhelm, Ellen Caldwell, Stephen J. Salipante, Douglas B. Hornick, Richard Siehnel, Lev Becker, Bradley E. Britigan, Pradeep K. Singh - Science Translational Medicine 2018 被引用: 356

lung infection in a preliminary phase 1 clinical trial. These findings raise the possibility that human infections could be treated by targeting iron metabolism or other nutritional vulnerabilities of bacterial pathogens.