Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress

著者: Mark Stoneley, Robert F. Harvey, Thomas E. Mulroney, Ryan Mordue, Rebekah Jukes‐Jones, Kelvin Cain, Kathryn S. Lilley, Ritwick Sawarkar, Anne E. Willis - Molecular Cell 2022 被引用: 101

signaling, and that this cell-cycle delay is prolonged when the ASCC cannot resolve stalled ribosomes. Thus, we propose that the sensitivity of stalled ribosomes to the ASCC influences the kinetics of stall resolution, which in turn controls the adaptive stress response.