Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

著者: Marios Giannakis, Xinmeng Jasmine Mu, Sachet A. Shukla, Zhi Rong Qian, Ofir Cohen, Reiko Nishihara, Samira Bahl, Yin Cao, Ali Amin‐Mansour, Mai Yamauchi, Yasutaka Sukawa, Chip Stewart, Mara Rosenberg, Kosuke Mima, Kentaro Inamura, Katsuhiko Nosho, Jonathan A. Nowak, Michael S. Lawrence, Edward L. Giovannucci, Andrew T. Chan, Kimmie Ng, Jeffrey A. Meyerhardt, Eliezer M. Van Allen, Gad Getz, Stacey B. Gabriel, Eric S. Lander, Catherine J. Wu, Charles S. Fuchs, Shuji Ogino, Levi A. Garraway - Cell Reports 2016 被引用: 930

(Cell Reports 15, 857–865; April 26, 2016) Table S3 has been updated. The updated version includes all somatic mutations used in our analyses. Genomic Correlates of Immune-Cell Infiltrates in Colorectal CarcinomaGiannakis et al.Cell ReportsApril 14, 2016In BriefThrough whole-exome sequencing of annotated colorectal tumors, Giannakis et al. identify additional colorectal cancer driver genes and correlate high neoantigen load with increased lymphocytic infiltration and improved survival. They also find positive selection for HLA mutations in immune-cell-infiltrated tumors. These results may inform immunotherapeutic approaches in colorectal cancer. Full-Text PDF Open Access