Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

著者: Ofir Wolach, Rob S. Sellar, Kimberly Martinod, Deya Cherpokova, Marie McConkey, Ryan Chappell, Alexander J. Silver, Dylan Adams, Cecilia A. Castellano, Rebekka K. Schneider, Robert F. Padera, Daniel J. DeAngelo, Martha Wadleigh, David P. Steensma, Ilene Galinsky, Richard M. Stone, Giulio Genovese, Steven A. McCarroll, Bozenna Iliadou, Christina M. Hultman, Donna Neuberg, Ann Mullally, Denisa D. Wagner, Benjamin L. Ebert - Science Translational Medicine 2018 被引用: 454

expression to NET formation and thrombosis and suggest that JAK2 inhibition may reduce thrombosis in MPNs through cell-intrinsic effects on neutrophil function.