A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

著者: Yan Zeng, William W. Du, Yingya Wu, Zhenguo Yang, Faryal Mehwish Awan, Xiangmin Li, Weining Yang, Chao Zhang, Qi Yang, Albert Yee, Yú Chen, Fenghua Yang, Huan Sun, Ren Huang, Albert Yee, Ren‐Ke Li, Zhongkai Wu, Peter H. Backx, Burton B. Yang - Theranostics 2017 被引用: 425

. Blocking oligonucleotides could reverse the effects of exogenous circ-Amotl1. We conclude that circ-Amotl1 physically binds to both PDK1 and AKT1, facilitating the cardio-protective nuclear translocation of pAKT.