Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

著者: Rosa de Groot, Marleen M. van Loenen, Aurélie Guislain, Benoît P. Nicolet, Julian J. Freen‐van Heeren, O. J. H. M. Verhagen, Michel M. van den Heuvel, Jeroen de Jong, Patrick Burger, C. Ellen van der Schoot, Robbert M. Spaapen, Derk Amsen, John B.A.G. Haanen, Kim Monkhorst, Koen J. Hartemink, Monika C. Wolkers - OncoImmunology 2019 被引用: 53

regulatory T cell infiltrates, suggesting that the composition of T cell infiltrates may predict the level of tumor reactivity. In conclusion, the effective generation of tumor-reactive and polyfunctional TIL products implies that TIL therapy will be a successful treatment regimen for NSCLC patients.