Multi-scale signaling and tumor evolution in high-grade gliomas

著者: Jingxian Liu, Song Cao, Kathleen J. Imbach, Marina A. Gritsenko, T. Mamie Lih, Jennifer Kyle, Tomer M. Yaron-Barir, Zev A. Binder, Yize Li, Ilya Strunilin, Yi-Ting Wang, Chia‐Feng Tsai, Weiping Ma, Lijun Chen, Natalie M. Clark, Andrew Shinkle, Nataly Naser Al Deen, Wagma Caravan, Andrew Houston, Faria Anjum Simin, Matthew A. Wyczalkowski, Liang-Bo Wang, Erik Storrs, Siqi Chen, Ritvik Illindala, Yuping D. Li, Reyka G. Jayasinghe, Dmitry Rykunov, Sandra Cottingham, Rosalie Chu, Karl Weitz, Ronald Moore, Tyler J. Sagendorf, Vladislav Petyuk, Michael Nestor, Lisa Bramer, Kelly G. Stratton, Athena Schepmoes, Sneha Couvillion, Josie Eder, Young‐Mo Kim, Yuqian Gao, Thomas Fillmore, Rui Zhao, Matthew Monroe, Austin N. Southard-Smith, Yang Eric Li, Rita Jui-Hsien Lu, Jared L. Johnson, Maciej Wiznerowicz, Galen Hostetter, Chelsea J. Newton, Karen A. Ketchum, Ratna R. Thangudu, Jill S. Barnholtz‐Sloan, Pei Wang, David Fenyö, Eunkyung An, Mathangi Thiagarajan, Ana I. Robles, D.R. Mani, Richard D. Smith, Eduard Porta‐Pardo, Lewis C. Cantley, Antonio Iavarone, Feng Chen, Mehdi Mesri, MacLean P. Nasrallah, Hui Zhang, Adam Resnick, Milan G. Chheda, Karin Rodland, Tao Liu, Li Ding, Anupriya Agarwal, Iyad Alnahhas, Mitual Amin, Eunkyung An, Matthew L. Anderson, David W. Andrews, Meenakshi Anurag, Jill S. Barnholtz-Sloan, Thomas Bauer, Jasmin Bavarva, Zev A. Binder, Michael J. Birrer, Uma Borate, Melissa Borucki, Lisa M. Bramer, Steven Brem, Shuang Cai, Lewis C. Cantley, Song Cao, Wagma Caravan, Steven A Carr, Daniel W. Chan, Lijun Chen, Lin S. Chen, Xi S. Chen, David Chesla, Milan G. Chheda, Arul M. Chinnaiyan, Shrabanti Chowdhury, Rosalie K. Chu, Marcin P. Cieślik, Natalie M. Clark, Karl Clauser, Antonio Colaprico, Sandra L. Cottingham, Sneha P. Couvillion, Reese Crispen, Tomasz Czernicki, Fulvio D’Angelo, Emek Demir, Saravana Mohan Dhanasekaran, Li Ding, Marcin J. Domagalski, Yongchao Dou, Brian Druker, Josie Eder, Nathan J. Edwards, Jennifer Eschbacher, David Fenyő, Thomas H. Fillmore, Nikolay Gabrovski, Yuqian Gao, Luciano Garofano, Yifat Geffen, Gad Getz, Michael A. Gillette, Denis Golbin, Charles A. Goldthwaite, Marina A. Gritsenko, Zeynep Gumus, Ziad Hanhan, Beth Hermes, Tara Hiltke, Galen Hostetter, Andrew Houston, Chen Huang, Antonio Iavarone, Kathleen J. Imbach, Eric Jaehnig, Scott D. Jewell, Jared L. Johnson, Kevin D. Judy, Alicia Karz, Wojciech Kaspera, Karen A. Ketchum, Lyndon Kim, Young-Mo Kim, Mateusz P Koptyra, Ramani B Kothadia, Chandan Kumar-Sinha, Jennifer E. Kyle, John Y.K. Lee, Jonathan Lei, Felipe D. Leprevost, Kai Li, Qing Kay Li, Yize Li, Zibo Li, Yuxing Liao, Tung-Shing M. Lih, Jena Lilly, Jingxian Liu, Tao Liu, Rita Jui-Hsien Lu, Yin Lu, Jan Lubínski, Weiping Ma, William Maggio, Anna Malovannaya, D.R. Mani, Nina Martinez, Jason E. McDermott, Peter B. McGarvey, Mehdi Mesri, Simona Migliozzi, Matthew E. Monroe, Ronald J. Moore, Nataly Naser Al Deen, MacLean P. Nasrallah, Michael Nestor, Alexey I. Nesvizhskii, Chelsea J. Newton, Donald M. O’Rourke, Gilbert S. Omenn, Umut Ozbek, Oxana V. Paklina, Amanda G. Paulovich, Samuel H. Payne, Francesca Petralia, Vladislav A. Petyuk, Alexander R. Pico, Paul D. Piehowski, Alexander Pilozzi, Dmitris Placantonakis, Eduard Porta-Pardo, Olga Potapova, Barbara Pruetz, Adam C. Resnick, Boris Reva, Ana I. Robles, Karin D. Rodland, Henry Rodriguez, Daniel C. Rohrer, Brian Rood, Larissa Rossell, Kelly V. Ruggles, Dmitry Rykunov, Tyler Sagendorf, Atom Sarkar, Shankha Satpathy, Sara R. Savage, Eric E. Schadt, Athena A. Schepmoes, Scott R. Shepard, Zhiao Shi, Yvonne Shutack, Richard D. Smith, Lori J. Sokoll, Yingduo Song, Yizhe Song, Austin N. Southard-Smith, Jakub Stawicki, Phillip B. Storm, Kelly G. Stratton, Ilya Strunilin, Wojciech Szopa, Ratna R. Thangudu, Mathangi Thiagarajan, Cristina Tognon, Elie Traer, Chia-Feng Tsai, Shirley Tsang, Alan R. Turtz, Jeffrey Tyner, Negin Vatanian, Weiqing Wan, Liang-Bo Wang, Pei Wang, Yi-Ting Wang, Michael W. Weaver, Karl K. Weitz, Bo Wen, Jeffrey R. Whiteaker, Bart Williams, George D. Wilson, Maciej Wiznerowicz, Yige Wu, Matthew A. Wyczalkowski, Lijun Yao, Tomer M. Yaron, Eric L. Zager, Bing Zhang, Hui Zhang, Xu Zhang, Zhen Zhang, Rui Zhao, Jun Zhu - Cancer Cell 2024 被引用: 56

Although genomic anomalies in glioblastoma (GBM) have been well studied for over a decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular landscape of high-grade glioma, composed of IDH-wildtype GBM and IDH-mutant grade 4 astrocytoma, by integrating proteomic, metabolomic, lipidomic, and post-translational modifications (PTMs) with genomic and transcriptomic measurements to uncover multi-scale regulatory interactions governing tumor development and evolution. Applying 14 proteogenomic and metabolomic platforms to 228 tumors (212 GBM and 16 grade 4 IDH-mutant astrocytoma), including 28 at recurrence, plus 18 normal brain samples and 14 brain metastases as comparators, reveals heterogeneous upstream alterations converging on common downstream events at the proteomic and metabolomic levels and changes in protein-protein interactions and glycosylation site occupancy at recurrence. Recurrent genetic alterations and phosphorylation events on PTPN11 map to important regulatory domains in three dimensions, suggesting a central role for PTPN11 signaling across high-grade gliomas.