A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

著者: Emily Jane Davis, Lauren Broestl, Samira Abdulai-Saiku, Kurtresha Worden, Luke W. Bonham, Elena Miñones-Moyano, Arturo J. Moreno, Dan Wang, Kevin Chang, Gina Williams, Bayardo I. Garay, Iryna Lobach, Nino Devidze, Daniel Kim, Cliff Anderson-Bergman, Gui-Qiu Yu, Charles C. White, Julie A. Harris, Bruce L. Miller, David A. Bennett, Arthur P. Arnold, Phil L. De Jager, Jorge J. Palop, Barbara Panning, Jennifer S. Yokoyama, Lennart Mucke, Dena B. Dubal - Science Translational Medicine 2020 被引用: 181

was linked to higher brain expression and associated with less cognitive decline in aging and preclinical AD, suggesting its relevance to human brain health. Our study suggests a potential role for sex chromosomes in modulating disease vulnerability related to AD.