Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens

著者: Charles Burdet, Nathalie Grall, Morgane Linard, Antoine Bridier‐Nahmias, Michèle Benhayoun, Khadija Bourabha, Mélanie Magnan, Olivier Clermont, Camille d’Humières, Olivier Tenaillon, Érick Denamur, Laurent Massias, Sarah Tubiana, Loubna Alavoine, Antoine Andremont, France Mentré, Xavier Duval, for the CEREMI Group, Antoine Andremont, Charles Burdet, Xavier Duval, B. Fantin, Nathalie Grall, Estelle Marcault, Laurent Massias, France Mentré, Sarah Tubiana, Loubna Alavoine, Michèle Benhayoun, Fatima Djerdjour, Jean-Luc Ecobichon, Emila Ilic-Habensus, Albane Laparra, Milica Mandic, Marie Ella Nisus, Sandra Raine, Pascal Ralaimazava, Valérie Vignali, Antoine Andremont, Camille d’Humières, Nathalie Grall, Julie Riberty, Khadija Bourabha, Antoine Bridier Nahmias, Olivier Clermont, Érick Denamur, Mélanie Magnan, Olivier Tenaillon, Laurent Massias, Estelle Marcault, Marion Schneider, Isabelle Vivaldo, Charles Burdet, Morgane Linard, France Mentré - Antimicrobial Agents and Chemotherapy 2019 被引用: 67

spp., or noncommensal microorganisms was not significantly different between the groups. Both antibiotics reduced the counts of total Gram-negative enteric bacilli and decreased the bacterial diversity, but the differences between the groups were not significant. All but one volunteer from each group exhibited undetectable levels of antibiotic in feces. Plasma pharmacokinetic endpoints were not correlated to alteration of the bacterial diversity of the gut. Both antibiotics markedly impacted the intestinal microbiota, but no significant differences were detected when standard clinical doses were administered for 3 days. This might be related to the similar daily amounts of antibiotics excreted through the bile using a clinical regimen. (This study has been registered at ClinicalTrials.gov under identifier NCT02659033.).