Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation

著者: Juan Pablo López, Elena Brivio, Alice Santambrogio, Carlo De Donno, Aron Kos, Miriam Peters, Nicolas Rost, Darina Czamara, Tanja Brückl, Simone Roeh, Max L. Pöhlmann, Clara Engelhardt, Andrea Ressle, Rainer Stoffel, Alina Tontsch, Javier M. Villamizar, Martín Reincke, Anna Riester, Silviu Sbiera, Martin Faßnacht, Helen S. Mayberg, W. Edward Craighead, Boadie W. Dunlop, Charles B. Nemeroff, Mathias V. Schmidt, Elisabeth B. Binder, Fabian J. Theis, Felix Beuschlein, Cynthia L. Andoniadou, Alon Chen - Science Advances 2021 被引用: 91

cells involved in stress adaptation in the adrenal gland. We validated our findings in a mouse stress model, adrenal tissues from patients with Cushing's syndrome, adrenocortical cell lines, and peripheral cortisol and genotyping data from depressed patients. This extensive dataset provides a valuable resource for researchers and clinicians interested in the organism's nervous and endocrine responses to stress and the interplay between these tissues. Our findings raise the possibility that modulating ABCB1 function may be important in the development of treatment strategies for patients suffering from metabolic and stress-related psychiatric disorders.