Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry

著者: Luís R. Lopes, Maria Angela Losi, Nabeel Sheikh, Cécile Laroche, Philippe Charron, Juan R. Gimeno, Juan Pablo Kaski, Aldo P. Maggioni, Luigi Tavazzi, Eloisa Arbustini, Dulce Brito, Jelena Čelutkienė, Albert Hagège, Aleš Linhart, Jens Mogensen, José Manuel García‐Pinilla, Tomás Ripoll‐Vera, Hubert Seggewiß, Eduardo Villacorta, Alida Caforio, Perry Elliott, The Cardiomyopathy Registry Investigators Group, Chris P Gale, Branko Beleslin, Andrzej Budaj, Ovidiu Chioncel, Nikolaos Dagres, Nicolas Danchin, David Erlinge, Jonathan Emberson, Michael Glikson, Alastair Gray, Meral Kayıkçıoğlu, Aldo P. Maggioni, Klaudia Vivien Nagy, Aleksandr Nedoshivin, Anna-Sonia Petronio, Jolien Roo Hesselink, Lars Wallentin, Uwe Zeymer, Alida Caforio, Juan R. Gimeno, Philippe Charron, Perry Elliott, Juan Pablo Kaski, Aldo P. Maggioni, Luigi Tavazzi, Michał Tendera, С. М. Комиссарова, Н. Н. Чакова, S. S. Niyazova, Aleš Linhart, Petr Kuchynka, T Palecek, Jana Podzimková, Marek Fikrle, Eneida R. Nemecek, Henning Bundgaard, Jacob Tfelt‐Hansen, Juliane Theilade, Jens Jakob Thune, Å.B. Axelsson, Jens Mogensen, F.L. Henriksen, Thomas Morris Hey, Søren K. Nielsen, Lars Videbæk, Simon Andreasen, H Arnsted, Anas M. Saad, Muzaffar Ali, Jyri Lommi, Tiina Heliö, M S Nieminen, Olivier Dubourg, Nicolas Mansencal, Murat Nihat Arslan, V. Siam Tsieu, Thibaud Damy, Aziz Guellich, Soulef Guendouz, Claire Marie Tissot, Aurélia Lamine, Stéphane Rappeneau, Albert Hagège, Michel Desnos, A Bachet, M. Hamzaoui, Philippe Charron, R Isnard, L. Legrand, Carole Maupain, Estelle Gandjbakhch, Mathieu Kernéis, J.F. Pruny, Anna Bauer, Barbara Pfeiffer, S B Felix, Marcus Dörr, S Kaczmarek, Kristin Lehnert, A. K. Pedersen, Daniel Beug, Michael Bruder, Michael Böhm, Ingrid Kindermann, Yvonne Linicus, Christian Werner, B Neurath, M Schild-Ungerbuehler, Hubert Seggewiß, Barbara Pfeiffer, A Neugebauer, Peter P. McKeown, Alison Muir, J McOsker, T Jardine, George Divine, Perry Elliott, Massimiliano Lorenzini, Oliver Watkinson, Eleanor Wicks, H Iqbal, Saidi Mohiddin, Constantinos O’Mahony, N Sekri, G. Carr-White, Teofila Bueser, Ronak Rajani, Lauren Clack, Julia Damm, Siana Jones, Ruth Sanchez-Vidal, Melody Smith, Tomos E. Walters, K. Wilson, S Rosmini, Aris Anastasakis, K Ritsatos, V Vlagkouli, T. Forster, Róbert Sepp, J Borbas, V. Nagy, Annamária Tringer, Kornél Kákonyi, L A Szabo, Majid Maleki, F Noohi Bezanjani, Ahmad Amin, Nasim Naderi, Mozhgan Parsaee, Sepideh Taghavi, Behshid Ghadrdoost, Sahar Jafari, Meysam Khoshavi, Claudio Rapezzi, Elena Biagini, Anna Corsini, Christian Gagliardi, Maddalena Graziosi, Simone Longhi, Agnese Milandri, Luca Ragni, Stefano Palmieri, Iacopo Olivotto, Anna Arretini, G Castelli, Franco Cecchi, Adalgiza Fornaro, Benedetta Tomberli, Paolo Spirito, Emmanuela Devoto, Paolo Della Bella, Giuseppe Maccabelli, Simone Sala, Fabrizio Guarracini, Giovanni Peretto, Maria Giovanna Russo, Raffaele Calabrò, Giuseppe Pacileo, Giuseppe Limongelli, Daniele Masarone, Vittorio Pazzanese, A. Rea, Marta Rubino, Stefania Tramonte, Fabio Valente, Martina Caiazza, Annapaola Cirillo, Giuseppe Del Giorno, Augusto Esposito, Rita Gravino, Tommaso Marrazzo, Bruno Trimarco, M-A Losi, Carlo Di Nardo, A Giamundo, Francesca Musella, F Pacelli, A Scatteia, Grazia Canciello, Alida L.P. Caforio, Sabino Iliceto, Chiara Calore, Loira Leoni, Martina Perazzolo Marra, Ilaria Rigato, Giuseppe Tarantini, Alessandro Schiavo, Martina Testolina, Eloisa Arbustini, Alessandro Di Toro, Livio Giuliani, Alessandra Serio, Francesco Fedele, Andrea Frustaci, Maria Alfarano, Cristina Chimenti, Fabrizio Drago, Anwar Baban, Leonardo Calò, Chiara Lanzillo, Annamaria Martino, Mariagrazia Uguccioni, Elisabetta Zachara, Géza Hálasz, Federica Re, Gianfranco Sinagra, Cosimo Carriere, Marco Merlo, Federica Ramani, Aušra Kavoliūnienė, Aušra Krivickienė, Eglė Tamulevičiūtė-Prascienė, Mindaugas Vieželis, Jelena Čelutkienė, L Balkeviciene, Monika Laukytė, Eglė Palevičiūtė, Yigal M. Pinto, Arthur A.M. Wilde, Folkert W. Asselbergs, Arjan Sammani, Joris van der Heijden, L Van Laake, Nicolaas de Jonge, RJ Hassink, J. H. Kirkels, Jayne N. Ajuluchukwu, Akinsanya Olusegun‐Joseph, Ekanem N. Ekure, Katarzyna Mizia­‐Stec, Michał Tendera, A Czekaj, A. Sikora-Puz, Anna Skoczyńska, Maciej Wybraniec, Paweł Rubiś, Ewa Dziewięcka, S Wisniowska-Smialek, Zofia T. Bilińska, Przemysław Chmielewski, Bogna Foss-Nieradko, Ewa Michalak, M Stepien-Wojno, B Mazek, Luís R. Lopes, A R Almeida, Inés Cruz, Ana Catarina Gomes, Ana Rita Pereira, Dulce Brito, Hugo Madeira, A.R. Francisco, Miguel Nobre Menezes, Oana Moldovan, Taís Guimarães, Dı́lson Silva, Carmen Ginghină, Ruxandra Jurcuţ, A Mursa, B A Popescu, Eduard Apetrei, Sebastian Militaru, Ioan Mircea Coman, Attila Frigy, Zoltán Fogarasi, Ildikó Kocsis, István Adorján Szabó, Lajos Fehérvári, И. Г. Никитин, Ernesto Resnik, Maria Komissarova, V.B. Lazarev, M Shebzukhova, D. V. Ustyuzhanin, О. В. Благова, Irina B. Alieva, V Kulikova, Yu. A. Lutokhina, E. V. Pavlenko, N. V. Varionchik, Arsen Ristić, Petar Seferović, Ivana Veljić, Ivana Živković, Ivan Milinković, Aleksandra Pavlović, Goran Radovanović, Dejan Simeunović, Marija Zdravković, M. Aleksic, Jelena Djokić, Saša Hinić, Slobodan Klašnja, Katarina Mircetic, Lorenzo Monserrat, Xusto Fernández, D Garcia-Giustiniani, José M. Larrañaga‐Moreira, Martín Ortiz-Genga, Roberto Barriales‐Villa, Cristina Martinez‐Veira, Elena Veira, Ángel Cequier, Joel Salazar‐Mendiguchía, Nicolás Manito, J Gonzalez, Francesc Fernández‐Avilés, Constancio Medrano, Raquel Yotti, Sofía Cuenca, María Ángeles Espinosa, Irene Méndez, Eduardo Zatarain‐Nicolás, R. Alvarez, Pablo García Pavía, Abelardo Morales Briceño, Marta Cobo Marcos, Fernándo Domínguez, Eduardo de Teresa Galván, José M García Pinilla, Nasiba Abdeselam‐Mohamed, Miguel A. López-Garrido, Luis Morcillo‐Hidalgo, María Victoria Ortega-Jiménez, Ainhoa Robles Mezcua, Ana Guijarro-Contreras, Diego Mauricio Gómez-García, María Robles-Mezcua, Juan Ramón Gimeno Blanes, F J Castro, Carmen Muñoz Esparza, Marcos Molina, M Sorli García, David López Cuenca, Palma de Mallorca, Tomás Ripoll‐Vera, J. Álvarez, J Nunez, Y. Gómez, P L Sanchez Fernandez, Eduardo Villacorta, C Avila, Loreto Bravo, Elena Díaz-Peláez, María Gallego‐Delgado, L Garcia-Cuenllas, Beatriz Plata Izquierdo, José López‐Haldón, M L Pena Pena, E M Cantero Perez, Esther Zorio, Miguel Á. Arnau, Javier Sanz, Elena Marqués‐Sulé - European Heart Journal - Quality of Care and Clinical Outcomes 2022 被引用: 44

AIMS: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. METHODS AND RESULTS: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. CONCLUSION: Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.