NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions

著者: Valentina Cazzetta, Elena Bruni, Sara Terzoli, Claudia Carenza, Sara Franzese, Rocco Piazza, Paolo Marzano, Matteo Donadon, Guido Torzilli, Matteo Cimino, Matteo Simonelli, Lorenzo Bello, Anna Villa, Likai Tan, Sarina Ravens, Immo Prinz, Domenico Supino, Federico Colombo, Enrico Lugli, Emanuela Marcenaro, Éric Vivier, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio - Cell Reports 2021 被引用: 75

tumors. This is highly relevant in the clinic, as the different degrees of engagement of the NKG2A-HLA-E checkpoint in hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer directly impact patients' overall survival. These findings open avenues for developing combined cellular and immunologic anticancer therapies.