In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response

著者: Aurélien Sutra Del Galy, Silvia Menegatti, Jaime R. Fuentealba, Francesca Lucibello, Laëtitia Perrin, Julie Helft, Aurélie Darbois, Michael Saitakis, Jimena Tosello, Derek C. Rookhuizen, Marc Deloger, Pierre Gestraud, Gèrard Socié, Sebastián Amigorena, Olivier Lantz, Laurie Menger - Science Immunology 2021 被引用: 74

T cells. Together, these findings identify SOCS1 as a major intracellular negative checkpoint of adoptive T cell response, opening new possibilities to optimize CAR-T cell therapy composition and efficacy.