Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption

著者: Marilyn C. Cornelis, Keri L. Monda, Kai Yu, Nina P. Paynter, Elizabeth M. Azzato, Siiri Bennett, Sonja I. Berndt, Eric Boerwinkle, Stephen J. Chanock, Nilanjan Chatterjee, David Couper, Gary C. Curhan, Gerardo Heiss, Frank B. Hu, David J. Hunter, Kevin B. Jacobs, Majken K. Jensen, Peter Kraft, Maria Teresa Landi, Jennifer A. Nettleton, Mark P. Purdue, Preetha Rajaraman, Eric B. Rimm, Lynda M. Rose, Nathaniel Rothman, Debra T. Silverman, Rachael Z. Stolzenberg‐Solomon, Amy F. Subar, Meredith Yeager, Daniel I. Chasman, Rob M. van Dam, Neil E. Caporaso - PLoS Genetics 2011 被引用: 234

We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.