PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

著者: Xinxin Song, Jiao Liu, Feimei Kuang, Xin Chen, Herbert J. Zeh, Rui Kang, Guido Kroemer, Yangchun Xie, Daolin Tang - Cell Reports 2021 被引用: 259

inhibitors in vitro and in suitable preclinical mouse models (e.g., a high-fat diet diabetes model). These findings reveal metabolic reprogramming as a potential target for overcoming ferroptosis resistance.