Response to Repeated Platelet Transfusion from the Same Donor
Article1 September 1963Response to Repeated Platelet Transfusion from the Same DonorEMIL J. FREIREICH, M.D., ALLAN KLIMAN, M.D., LAWRENCE A. GAYDOS, M.D., NATHAN MANTEL, M.A., EMIL FREI III, M.D.EMIL J. FREIREICH, M.D., ALLAN KLIMAN, M.D., LAWRENCE A. GAYDOS, M.D., NATHAN MANTEL, M.A., EMIL FREI III, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-3-277 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMore than a half century has passed since Duke (2) demonstrated that transfusion of platelets to thrombocytopenic patients could raise the circulating platelet count and arrest hemorrhage. These observations have been repeatedly confirmed in man and experimental animals (3-6). Nevertheless, platelet transfusion therapy is not widely practiced but is reserved for short-term treatment of thrombopenia associated with serious hemorrhage or for preoperative use (3-5, 7). A major reason for this is an inadequate supply of platelets for transfusion. The short platelet life-span of 5 to 8 days necessitates frequent transfusions, and because no effective storage technique is known, only freshly...References1. FREIREICHKLIMANGAYDOSSCHROEDER EJALALR: Response to repeated platelet transfusions from the same donor. J. Clin. Invest. 40: 1039, 1961. Google Scholar2. DUKE WW: The relation of blood platelets to hemorrhagic disease: description of a method for determining the bleeding time and the coagulation time and report of three cases of hemorrhagic disease relieved by transfusion. JAMA 55: 1185, 1910. CrossrefGoogle Scholar3. FARBERKLEIN SE: The nature and control of bleeding in acute leukemia and other thrombocytopenic states. Ann. Paediat. Fenn. 3: 348, 1957. MedlineGoogle Scholar4. CRONKITEJACKSON EPDP: Use of platelet transfusions in hemorrhagic disease, in Progress in Hematology, Vol. II, Grune and Stratton, Inc., New York, 1959, p. 239. Google Scholar5. GARDNERCOHEN FHP: The value of platelet transfusions. Med. Clin. N. Amer. 44: 1425, 1960. CrossrefMedlineGoogle Scholar6. FREIREICHSCHMIDTSCHNEIDERMANFREI EJPJMAE: A comparative study of the effect of transfusion of fresh and preserved whole blood on bleeding in patients with acute leukemia. New Eng. J. Med. 260: 6, 1959. CrossrefMedlineGoogle Scholar7. CONLEY CL: Blood platelets and platelet transfusions. Arch. Intern. Med. (Chicago) 107: 67, 1961. CrossrefGoogle Scholar8. KLIMANGAYDOSSCHROEDERFREIREICH ALALREJ: Repeated plasmapheresis of blood donors as a source of platelets. Blood 18: 303, 1961. CrossrefMedlineGoogle Scholar9. BRECHERSCHNEIDERMANCRONKITE GMEP: Reproducibility and constancy of platelet count. Amer. J. Clin. Path. 23: 15, 1953. CrossrefMedlineGoogle Scholar10. SENDROYCECCHINI JLP: Determination of human body surface area from height and weight. J. Appl. Physiol. 7: 1, 1954. CrossrefMedlineGoogle Scholar11. ASTERLEVINCOOPERFREIREICHMORSESINGER RHRHHEEJEEDL: Correlation of complement-fixing antibodies with platelet survival in thrombopenic patients. Clin. Res. 10: 195, 1962. Google Scholar12. GAYDOSFREIREICHMANTEL LAEJN: The quantitative relationship between platelet count and hemorrhage in patients with acute leukemia. New Eng. J. Med. 266: 905, 1962. CrossrefMedlineGoogle Scholar13. SALVIDIOCROSBY EWH: Thrombocytopenia after intravenous injection of India ink. J. Lab. Clin. Med. 56: 711, 1960. MedlineGoogle Scholar14. STEBBINSFLOREY WEHW: The behavior of intravenously injected particles observed in chambers in rabbit ears. Quart. J. Exp. Path. 45: 252, 1960. Google Scholar15. JOHANSON S: Inhibition of thrombocytopenia and 5-hydroxytryptamine release in anaphylactic shock by heparin. Acta Physiol. Scand. 50: 95, 1960. CrossrefMedlineGoogle Scholar16. MURPHYMUSTARD LAJF: Platelet economy during moderate and intensive dicoumarol therapy. Lancet 7209: 960, 1961. CrossrefGoogle Scholar17. ADELSONRHEINGOLDPARKERBUENAVENTURACROSBY EJJOAWH: Platelet and fibrinogen survival in normal and abnormal states of coagulation. Blood 17: 267, 1961. CrossrefMedlineGoogle Scholar18. COHENGARDNER PFH: Platelet preservation of canine platelet concentrates by freezing in solutions of glycerol plasma. J. Clin. Invest. 41: 10, 1962. CrossrefMedlineGoogle Scholar19. CORNUPSHAW MJD: Evaluation of platelet antibodies in idiopathic thrombocytopenic purpura. Arch. Intern. Med. 109: 157, 1962. CrossrefGoogle Scholar20. COHENGARDNERBARNETT PFHGO: Reclassification of the thrombocytopenias by the Cr51-labeling method for measuring platelet life span. New Eng. J. Med. 264: 1294, 1961. CrossrefMedlineGoogle Scholar21. SHULMANASTERLEITNERHILLER NRRHAMC: Immunoreactions involving platelets. V. Post-transfusion purpura due to a complement fixing antibody against a genetically controlled platelet antigen. A proposed mechanism for thrombocytopenia and its relevance in "autoimmunity." J. Clin. Invest. 40: 1597, 1961. CrossrefMedlineGoogle Scholar22. SILVERUTZFAHEYFREI RTJPJE: Antibody response in patients with acute leukemia. J. Lab. Clin. Med. 56: 634, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the National Cancer Institute and the Division of Biologic Standards, National Institutes of Health, Bethesda, Maryland.An abstract of this paper has been previously published (1).Requests for reprints should be addressed to Emil J. Freireich, M.D., National Institutes of Health, Bethesda, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEffect of bedside filtration on aggregates from cold‐stored whole blood–derived platelet‐rich plasma and apheresis platelet concentratesHistoryTransfusion Therapy in Specific Clinical SituationsPediatric Transfusion MedicinePediatric Cancer Outcomes in an Intensive Care Unit in PakistanPlatelet and Granulocyte TransfusionHistoryTransfusion Therapy in Specific Clinical SituationsCurrent Status of Platelet Transfusion in Pediatric PatientsPlatelet Transfusions in Patients with Hypoproliferative ThrombocytopeniaTransfusion in Critically Ill ChildrenThe Transfusion of Platelets, Leucocytes, Haematopoietic Progenitor Cells and Plasma ComponentsPlatelet and Granulocyte TransfusionPrise en charge transfusionnelle des hémopathies malignes en 2012 : évolution des recommandationsHistoryClinical Uses of Blood ComponentsTransfusion Therapy in Specific Clinical SituationsOrigins of Platelet Transfusion TherapyTransfusion medicine for pathologistsUse of random versus apheresis platelet concentratesPlatelet components todayThe case for a new approach for documenting platelet viabilityA critical comparison of platelet preparation methodsTriggers for prophylactic use of platelet transfusions and optimal platelet dosing in thrombocytopenic dogs and catsPlatelet storage solution improves the in vitro function of preserved platelet concentrateProphylactic platelet transfusions: which dose is the best dose? A review of the literaturePlatelet dosingPlatelet therapyEconomic consequences of alterations in platelet transfusion dose: analysis of a prospective, randomized, double-blind trialSupportive care for patients with blood disordersClinical consequences of alterations in platelet transfusion dose: a prospective, randomized, double-blind trialPotential Clinical Applications of Thrombopoietic Growth FactorsPlatelets: What Qualities and Characteristics do Justify the Need for Transfusion?Reliability of automated platelet counts: Comparison with manual method and utility for prediction of clinical bleedingRelative Importance of Immune and Non-Immune Causes of Platelet RefractorinessThe role of ABO matching in platelet transfusionClinical Efficacy of Platelet ConcentratesApplication of INSTAT hemostat in the control of gingival hemorrhage in the patient with thrombocytopeniaA Study of the Effect of AB0 Incompatible Plasma in Platelet Concentrates Transfused to Bone Marrow Transplant RecipientsPlatelet transfusion therapy for thrombocytopeniaAlloimmunization as a Problem for Platelet TransfusionPlatelet Transfusion TherapyHematologic Support of the Patient with MalignancyTherapie mit ThrombozytenPractical Aspects of Platelet Concentrate Production and StorageEscherichia coli bacteremia in cancer patientsPlatelet and Granulocyte Transfusions in Cancer PatientsPlatelet transfusion therapy in acute leukemia: Lack of effect of splenomegaly on transfusion requirements and risk of hemorrhagePlatelets for transfusion: collection, storage and clinical efficacyCharles F. Kettering prize. Acute leukemia. A prototype of disseminated cancerCombined Granulocyte and Platelet Transfusions: Inter-Relationship between Granulocyte and Platelet Recoveries in the Presence and Absence of Complicating FactorsTransfusion of Platelets and Plasma ProductsSerological studies in patients on platelet- and granulocyte-substitution therapyIndications for platelet transfusion in children with acute leukemiaPlatelet TherapyAplastic Anemia: Biology and TreatmentROBERT PETER GALE, M.D., Ph.D., RICHARD E. CHAMPLIN, M.D., STEPHEN A. FEIG, M.D., JOHN H. FITCHEN, M.D.Clinical Evaluation of Platelet Transfusions in Thrombocytopenic Patients: Methods and InterpretationChemotherapy and immunotherapy for acute myelogenous leukemiaOncology Grand Rounds: Platelet transfusion—clinical applications in the oncology settingThrombocytopenia: Mechanisms and Management of Defects in Platelet ProductionBlood component therapyKomplikationen und supportive Therapie der Leukämien und malignen Non-Hodgkin-LymphomePlatelet Transfusion TherapyStatewide Support of Thrombocytopenic Patients with ABO Matched Single Donor PlateletsManagement of Complications in the Course of Malignant DiseaseThe Prophylactic Treatment of Thrombocytopenic Leukemic Patients with Platelets: a Double Blind StudyUSE OF PLATELET TRANSFUSIONSTransfusion of Neutrophils as Prevention or Treatment of Infection in Patients with NeutropeniaEfficacy of Platelet Transfusions from HL-A Compatible Unrelated Donors to Alloimmunized PatientsErfahrungen zur klinischen Anwendung der ZelltrifugeBlood transfusion: Merits of component therapyPlatelet Transfusions From HL-A Compatible Unrelated Donors to Alloimmunized PatientsHANS-PETER LOHRMANN, M.D., MALCOLM I. BULL, M.D., JULIAN A. DECTER, M.D., RONALD A. YANKEE, M.D., ROBERT G. GRAW Jr., M.D.Selection of Unrelated Compatible Platelet Donors by Lymphocyte HL-A MatchingPrinciples of Hematologic Supportive CareSeparation of Platelet Rich Plasma and Red Cells with Modified GelatinPlatelet Transfusion TherapyTHE MANAGEMENT OF APLASTIC ANAEMIA IN ADULTSRh-Incompatible Platelet Transfusions - Risks and Consequences of Sensitizing Immunosuppressed PatientsLeukocyte and Platelet Collection from Normal Donors with the Continuous Flow Blood Cell SeparatorCurrent cancer chemotherapy in obstetrics and gynecologyCLINICAL DISORDERS RELATED TO BLOOD PLATELETSTRANSFUSION AND PRESERVATIONOral Complications of the Myeloproliferative DiseasesLong-Term Platelet Support of Patients with Aplastic Anemia Effect of Splenectomy and Steroid TherapyF. CARL GRUMET, M.D., RONALD A. YANKEE, M.D.Circulation of Concentrated One-day-old Platelets in VivoPlatelet Transfusion TherapyLITERATURVERZEICHNISBIBLIOGRAPHYDie Thrombozyten-TransfusionClinical Effectiveness of Platelet Concentrates Prepared with or without Acidification of the PlasmaTherapy for Blood Disorders in Infants and ChildrenThe use of an isolator system in cancer chemotherapyTransfusion of Fresh Platelet Concentrates to Adult Patients with ThrombocytopeniaStructure-Activity Analysis of Tetrahydrofolate Analogs Using Substituent Constants and Regression AnalysisEffect of platelet transfusion on hemorrhage in patients with acute leukemia: An autopsy studyPlatelet TransfusionPreparation and in Vivo Circulation of Human Platelets Preserved with Combined Dimethylsulfoxide and DextroseThe Use of Platelet TransfusionsTransfusion of Platelet Concentrates Prepared from Acidified Platelet-Rich PlasmaPlatelet PreservationPulmonary complications of acute leukemiaPreparation of Platelet Concentrates for Transfusion Employing Adenosine DiphosphateThe Anticoagulants of Choice for Platelet TransfusionsImmunological Considerations Attending Platelet TransfusionEffectiveness of Platelet Transfusion in Leukemia and Aplastic AnemiaThe Role of Platelet Administration in a Blood Transfusion ServicePhysiologic Observations in Human Cross CirculationPlatelet PreservationBreast Cancer Combined Clinical Staff Conference at the National Institutes of HealthNATHANIEL I. BERLIN, M.D., HOWARD B. ANDERVONT, D.SC., MICHAEL B. SHIMKIN, M.D., B. J. KENNEDY, M.D., EMIL FREI III, M.D.Response to Transfusion of Platelets Pooled from Multiple Donors and the Effects of Various Technics of Concentrating PlateletsProgress and Perspectives in the Chemotherapy of Acute LeukemiaThe Gastrointestinal Lesions and Complications of the LeukemiasJ. C. PROLLA, M.D., JOSEPH B. KIRSNER, M.D., F.A.C.P.Complement-Fixing Platelet Iso-Antibodies in Serum of Transfused Persons. Correlation of Antibodies with Platelet Survival in Thrombocytopenic PatientsEffect of Storage up to 48 Hours on Response to Transfusions of Platelet Rich PlasmaQuantitative Concepts in the Clinical Study of Drugs 1 September 1963Volume 59, Issue 3Page: 277-287KeywordsBiologicsBlood plasmaHemorrhagePlateletsSepsisThrombocytopenia Issue Published: 1 September 1963 PDF DownloadLoading ...