Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice

著者: Shahanshah Khan, Sumyya Waliullah, Victoria Godfrey, Md Abdul Wadud Khan, Rajalaksmy A. Ramachandran, Brandi L. Cantarel, Cassie L. Behrendt, Lan Peng, Lora V. Hooper, Hasan Zaki - Science Translational Medicine 2020 被引用: 313

mice. Sugar-induced exacerbation of colitis was not observed when mice were treated with antibiotics or maintained in a germ-free environment, suggesting that altered microbiota played a critical role in sugar-induced colitis pathogenesis. Furthermore, germ-free mice colonized with microbiota from sugar-treated mice showed increased colitis susceptibility. Together, these data suggest that intake of simple sugars predisposes to colitis and enhances its pathogenesis via modulation of gut microbiota in mice.