Transforming growth factor β1 (TGFβ1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis

著者: Shibnath Ghatak, Vincent Hascall, Roger R. Markwald, Carol Feghali‐Bostwick, Carol M. Artlett, Mónika Göőz, Galina S. Bogatkevich, Ilia Atanelishvili, Richard M. Silver, Jeanette M. Wood, Victor J. Thannickal, Suniti Misra - Journal of Biological Chemistry 2017 被引用: 84

shRNA) or a small molecule inhibitor (CD44v6 peptide) targeting of CD44v6 abrogates fibrogenesis in murine models of lung injury. These studies support a function for CD44V6 in lung fibrosis and offer proof of concept for therapeutic targeting of CD44V6 in lung fibrosis disorders.