Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition

著者: Grace Huang, Zhongjian Cheng, Alycia N. Hildebrand, Chunlin Wang, Maria Cimini, Rajika Roy, Anna Maria Lucchese, Cindy Benedict, Vandana Mallaredy, Ajit Magadum, Darukeshwara Joladarashi, Charan Thej, Carolina González, May Trungcao, Venkata Naga Srikanth Garikipati, John W. Elrod, Walter J. Koch, Raj Kishore - Theranostics 2022 被引用: 41

Our findings unravel that diabetes impairs EPC-EV reparative function in the ischemic heart, at least partially, through HDACs-mediated H3K9Ac downregulation leading to transcriptional suppression of angiogenic, proliferative and cell survival genes in recipient cardiac ECs. Thus, HDAC inhibitors may potentially be used to restore the function of diabetic EPC and other stem cells for autologous cell therapy applications.