Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

著者: Michael D. Onken, Carol M. Makepeace, Kevin M. Kaltenbronn, Stanley M. Kanai, Tyson D. Todd, Shiqi Wang, Thomas J. Broekelmann, P. Kumar Rao, John A. Cooper, Kendall Blumer - Science Signaling 2018 被引用: 106

and PRC2 therefore provide therapeutic targets for UM. The development of FR analogs specific for other Gα subunit subtypes may provide novel therapeutic approaches for diseases driven by constitutively active Gα subunits or multiple G protein-coupled receptors (GPCRs) where targeting a single receptor is ineffective.