Wnt Signaling and Injury Repair

著者: Jemima Whyte, Andrew A. Smith, Jill A. Helms - Cold Spring Harbor Perspectives in Biology 2012 被引用: 241

Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programmed cell death, to the mobilization of stem cell reservoirs within the wound site. In this review we summarize recent data elucidating the roles that the Wnt pathway plays in the injury repair process. These data provide a foundation for potential Wnt-based therapeutic strategies aimed at stimulating tissue regeneration.