Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor

著者: Benjamin M. Hariri, Derek B. McMahon, Bei Chen, Jenna R. Freund, Corrine Mansfield, Laurel Doghramji, Nithin D. Adappa, James N. Palmer, David W. Kennedy, Danielle R. Reed, Peihua Jiang, Robert J. Lee - Journal of Biological Chemistry 2017 被引用: 128

soleucine at positions 49, 262, and 296, respectively) T2R38. Our data demonstrate that T2R14 in sinonasal cilia is a potential therapeutic target for upper respiratory infections and that flavones may have clinical potential as topical therapeutics, particularly in T2R38 AVI/AVI individuals.