Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

著者: Michael Ewers, Nicolai Franzmeier, Marc Suárez‐Calvet, Estrella Morenas‐Rodríguez, Miguel Ángel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, Christian Haass, Alzheimer’s Disease Neuroimaging Initiative - Science Translational Medicine 2019 被引用: 337

These results suggest that sTREM2 is associated with attenuated cognitive and clinical decline, a finding with important implications for future clinical trials targeting the innate immune response in AD.