A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

著者: Matthew T. Wolf, Sudipto Ganguly, Tony L. Wang, Christopher W. Anderson, Kaitlyn Sadtler, Radhika Narain, Christopher Cherry, Alexis J. Parrillo, Benjamin V. Park, Guannan Wang, Fan Pan, Saraswati Sukumar, Drew M. Pardoll, Jennifer H. Elisseeff - Science Translational Medicine 2019 被引用: 131

T cell-dependent and macrophage-dependent manner. In-depth immune characterization revealed an activated type 2-like immune response that was distinct from the classical tumor microenvironment, including activated type 2 T helper T cells, a unique macrophage phenotype, eosinophil infiltration, angiogenic factors, and complement. Tumor growth inhibition by PD-1 and PD-L1 checkpoint blockade was potentiated in the UBM scaffold immune microenvironment. Engineering the local tumor microenvironment to promote a type 2 wound-healing immune signature may serve as a therapeutic target to improve immunotherapy efficacy.