Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade

著者: Yuying Jiang, Yongbing Yang, Yingchao Hu, Rui Yang, Jiajia Huang, Yi Liu, Yuqing Wu, Sheng Li, Chunmei Ma, Fiachra Humphries, Bingwei Wang, Xi Wang, Zhibin Hu, Shuo Yang - Cell Reports 2022 被引用: 50

T cell activation in a cGAS-dependent manner. Moreover, pharmacological inhibition of GSDMD-mediated pyroptosis and PD-L1 improve anti-tumor immunity, highlighting the potential of combining GSDMD/PD-L1 inhibition for immunotherapy as a therapeutic strategy.