Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

著者: Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin R. Farlow, Serge Gauthier, Tammie L.S. Benzinger, John C. Morris, Randall J. Bateman, John C.S. Breitner, Judes Poirier, Étienne Vachon‐Presseau, Sylvia Villeneuve, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Michael Weiner, Howard J. Rosen, Bruce L. Miller, Paul Aisen, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Ronald C. Petersen, Clifford R. Jack, Matt A. Bernstein, Bret Borowski, Jeff Gunter, Matthew L. Senjem, Prashanthi Vemuri, David T. Jones, Kejal Kantarci, Chad Ward, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, William J. Jagust, Susan Landau, John Q. Trojanowki, Arthur W. Toga, Karen Crawford, Scott Neu, Laurel Beckett, Danielle Harvey, Charles DeCarli, Robert C. Green, Andrew J. Saykin, Tatiana M. Foroud, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Scott Herring, Cynthia Hunt, Nigel J. Cairns, Erin Householder, Lisa Taylor Reinwald, Leslie M. Shaw, Steven E. Arnold, Jason Karlawish, S. J. Wolk, Enchi Liu, Tom Montine, Nick C. Fox, Paul M. Thompson, Norbert Schuff, Robert A. Koeppe, Judith L. Heidebrink, Joanne Lord, Norm Foster, Eric M. Reiman, Kewei Chen, Adam Fleisher, Pierre N. Tariot, Stephanie Reeder, Chet Mathis, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Virginia Lee, Magdalena Korecka, Michal Figurski, Steven Potkin, Zaven Kachaturian, Richard Frank, Peter J. Snyder, Susan Molchan, Jeffrey Kaye, Joseph F. Quinn, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Rachelle S. Doody, Javier Villanueva Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, John C. Morris, Beau M. Ances, Maria Carroll, Sue Leon, Mark A. Mintun, Stacy Schneider, Angela OliverNG, Randall Griffith, David G. Clark, David Geldmacher, John Brockington, Erik D. Roberson, Hillel Grossman, Effie Mitsis, Leyla deToledo‐Morrell, Raj C. Shah, Ranjan Duara, Daniel Varón, Maria T. Greig, Peggy Roberts, Marilyn Albert, Chiadi U. Onyike, Daniel D’Agostino, Stephanie Kielb, James E. Galvin, Dana M. Pogorelec, Brittany Cerbone, Christina A. Michel, Henry Rusinek, Mony J. de Leon, Lidia Glodzik, Susan De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Terence Z. Wong, Charles D. Smith, Gregory A. Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Ruth A. Mulnard, Gaby Thai, Catherine Mc Adams Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Ramon Diaz Arrastia, Richard King, Myron Weiner, Kristen Martin Cook, Michael D. Devous, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Heather S. Anderson, Russell H. Swerdlow, Liana G. Apostolova, Kathleen Tingus, Ellen Woo, Daniel Silverman, Po H. Lu, George Bartzokis, Neill R. Graff Radford, Francine ParfittH, Tracy Kendall, Heather Johnson, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra E. Black, Bojana Stefanovic, Curtis Caldwell, Ging‐Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly Past, Andrew Kertesz, John Rogers, Dick Trost, Charles Bernick, Donna Munic, Diana Kerwin, Marek Marsel Mesulam, Kristine Lipowski, Chuang Wu, Nancy Johnson, Carl Sadowsky, Walter Martínez, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall, Meghan Frey, Jerome A. Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil W. Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan J. Lerner, Paula Ogrocki, Leon Hudson, Evan Fletcher, Owen Carmichael, John Olichney, Smita Kittur, Michael Borrie, T. Y. Lee, Robert Bartha, Sterling C. Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven G. Potkin, Adrian Preda, Dana Nguyen, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Robert B. Santulli, Tamar J. Kitzmiller, Eben S. Schwartz, Kaycee M. SinkS, Jeff D. Williamson, Pradeep Kumar Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Jacobo Mintzer, Kenneth Spicer, David Bachman, Elizabeth Finger, Stephen Pasternak, Irina Rachinsky, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K. Schultz, Laura L. Boles Ponto, Hyungsub Shim, Karen E. Smith, Norman Relkin, Gloria Chaing, Lisa Raudin, Amanda Smith, Kristin Fargher, Balebail Ashok Raj, Dominantly Inherited Alzheimer Network (DIAN) Study Group, Ricardo Allegri, Randy Bateman, Jacob Bechara, Tammie L.S. Benzinger, Sarah Berman, Courtney Bodge, Susan E. Brandon, William S. Brooks, Jill Buck, Virginia Buckles, Sochenda Chea, Jasmeer P. Chhatwal, Patricio Chrem, Helena C. Chui, Jake Cinco, Tamara Donahue, Jane Douglas, Noelia Edigo, Nilufer Erekin-Taner, Anne M. Fagan, Marty Farlow, Colleen Fitzpatrick, Gigi Flynn, Erin Franklin, Hisako Fujii, Cortaiga Gant, Samantha L. Gardener, Bernardino Ghetti, Alison Goate, Jill Goldman, Brian A. Gordon, Neill R. Graff‐Radford, Julia Gray, Alexander Groves, Jason Hassenstab, Laura Hoechst-Swisher, David M. Holtzman, Russ C. Hornbeck, Siri Houeland DiBari, Takeshi Ikeuchi, Snežana Ikonomović, Clifford R. Jack, Gina Jerome, Celeste M. Karch, Kensaku Kasuga, Takeshi Kawarabayashi, William E. Klunk, Robert A. Koeppe, Elke Kuder-Buletta, Christoph Laske, Jae‐Hong Lee, Allan I. Levey, Ralph N. Martins, Neal Scott Mason, Colin L. Masters, Denise Maue-Dreyfus, Eric McDade, Hiroshi Mori, John C. Morris, Akem Nagamatsu, Katie Neimeyer, James M. Noble, Joanne Norton, Richard J. Perrin, Marc Raichle, Alan E. Renton, John M. Ringman, Jee Hoon Roh, Hiroyuki Shimada, Wendy Sigurdson, Hamid R. Sohrabi, Paige Sparks, Kazushi Suzuki, Kevin Taddei, Peter Wang, Chengjie Xiong, Xu Xiong, Pierre Bellec, Véronique D. Bohbot, M. Mallar Chakravarty, D. Louis Collins, Pierre Étienne, Alan C. Evans, Serge Gauthier, Rick Hoge, Yasser Ituria‐Medina, Vasavan Nair, Jamie Near, Natasha Rajah, Pedro Rosa‐Neto, Christine Tardif, Jennifer Tremblay‐Mercier, Étienne Vachon‐Presseau - Nature Communications 2021 被引用: 100

Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18-94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.