Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer

著者: Karla Rubio, Addi J. Romero‐Olmedo, Pouya Sarvari, Guruprasadh Swaminathan, Vikas Ranvir, Diana G. Rogel-Ayala, Julio Cordero, Stefan Günther, Aditi Mehta, Birgit Bassaly, Peter Braubach, Małgorzata Wygrecka, Stefan Gattenlöhner, Achim Tresch, Thomas Braun, Gergana Dobreva, Miguel N. Rivera, Indrabahadur Singh, Johannes Graumann, Guillermo Barreto - Theranostics 2023 被引用: 40

We uncovered a mechanism of ITGB2-mediated EGFR activation in SCLC that explains EGFR-inhibitor resistance independently of EGFR mutations, suggesting the development of therapies targeting ITGB2 for patients with this extremely aggressive lung cancer type.