Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

著者: Ludovic S. Mure, Hiep D. Le, Giorgia Benegiamo, Max W. Chang, Luis Ríos, Ngalla Jillani, Maina Ngotho, Thomas Kariuki, Ouria Dkhissi‐Benyahya, Howard M. Cooper, Satchidananda Panda - Science 2018 被引用: 815

(baboon). Genomic transcription was highly rhythmic, with up to 81.7% of protein-coding genes showing daily rhythms in expression. In addition to tissue-specific gene expression, the rhythmic transcriptome imparts another layer of functional specialization. Most ubiquitously expressed genes that participate in essential cellular functions exhibit rhythmic expression in a tissue-specific manner. The peak phases of rhythmic gene expression clustered around dawn and dusk, with a "quiescent period" during early night. Our findings also unveil a different temporal organization of central and peripheral tissues between diurnal and nocturnal animals.