Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

著者: Slobodan Čulina, Ana I. Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Østerbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Étienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Søren Buus, David A. Price, Matthias Kühn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat‐Zucman, Francesco Dotta, Raphaël Scharfmann, Bruno Kyewski, Roberto Mallone, ImMaDiab Study Group, Jean‐Claude Carel, Nadia Tubiana‐Rufi, Lætitia Martinerie, Amélie Poidvin, Évelyne Jacqz-Aigrain, Laurence Corvez, Véronique Berruer, Jean–François Gautier, Baz Baz, Nassima Haddadi, Fabrizio Andréelli, Chloé Amouyal, Sophie Jaqueminet, Olivier Bourron, Eric Dasque, Agnès Hartemann, Amal Lemoine-Yazigi, Danièle Dubois‐Laforgue, F. Travert, Marilyne Feron, Patrice Rolland, Valérie Vignali, Michel Marre, Philippe Chanson, Claire Briet, Pierre-Jean Guillausseau, Leila Ait-Bachir, Carole Collet, Frédéric Beziaud, V. Desforges-Bullet, Gwenaelle Petit-Aubert, Sophie Christin‐Maître, Bruno Fève, Camille Vatier, Nathalie Bourcigaux, Céline Lautridou, Najiba Lahlou, Prissile Bakouboula, Caroline Elie, Hélène Morel, Jean‐Marc Tréluyer, Marie‐Claude Gagnerault, Claire Maillard, Anna Jones - Science Immunology 2018 被引用: 261

T cells circulate in most individuals but home to the pancreas preferentially in T1D patients. We conclude that the activation of this common islet-reactive T cell repertoire and progression to T1D likely require defective peripheral immunoregulation and/or a proinflammatory islet microenvironment.