Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001

著者: Lynda M. Vrooman, Traci M. Blonquist, Marian H. Harris, Kristen E. Stevenson, Andrew E. Place, Sarah K. Hunt, Jane E. O’Brien, Barbara L. Asselin, Uma H. Athale, Luis A. Clavell, Peter D. Cole, Kara M. Kelly, Caroline Laverdière, Jean‐Marie Leclerc, Bruno Michon, Marshall A. Schorin, Maria Luisa Sulis, Jennifer Welch, Donna Neuberg, Stephen E. Sallan, Lewis B. Silverman - Blood Advances 2018 被引用: 115

Key Points Childhood B-ALL patients, including those with VHR features, had favorable outcomes on DFCI 05-001 risk-stratified therapy. IKZF1 deletion was an independent predictor of inferior outcome, including among patients with low end-induction MRD.