Insulin Secretion Depends on Intra-islet Glucagon Signaling

著者: Berit Svendsen, Olav Larsen, M Gabe, C. Christiansen, Mette M. Rosenkilde, Daniel J. Drucker, Jens J. Holst - Cell Reports 2018 被引用: 352

but not wild-type mice, suggesting that β cell GLP-1R activation results predominantly from glucagon action. Our results suggest that combined activity of glucagon and GLP-1 receptors is essential for β cell secretory responses, emphasizing a role for paracrine intra-islet glucagon actions to maintain appropriate insulin secretion.