Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis

著者: Amy I. Yu, Lili Zhao, Kathryn A. Eaton, Sharon L. Ho, Jiachen Chen, Sara Poe, James T. Becker, Allison Gonzalez, Delaney McKinstry, Muneer Hasso, Jonny Mendoza‐Castrejon, Joel Whitfield, Charles C. Koumpouras, Patrick D. Schloss, Eric C. Martens, Grace Chen - Cell Reports 2020 被引用: 176

T cells in tumors and adjacent tissues compared with mice that develop fewer tumors. Notably, intratumoral T cells in mice that develop more tumors exhibit increased exhaustion. Thus, these studies suggest that microbial dysbiosis can contribute to colon tumor susceptibility by hyperstimulating CD8 T cells to promote chronic inflammation and early T cell exhaustion, which can reduce anti-tumor immunity.