The m 6 A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor

著者: Yiren Xiao, Kaushik N. Thakkar, Hongjuan Zhao, James P. Broughton, Yang Li, José A. Seoane, Anh N. Diep, Thomas J. Metzner, Rie von Eyben, David L. Dill, James D. Brooks, Christina Curtis, John T. Leppert, Jiangbin Ye, Donna M. Peehl, Amato J. Giaccia, Subarna Sinha, Erinn B. Rankin - Proceedings of the National Academy of Sciences, PNAS 2020 被引用: 102

Significance Here we report a synthetic lethal interaction between the epitranscriptomic modifier FTO and the tumor suppressor VHL. Notably, FTO inhibition reduced the growth of both HIF wild type and HIF-deficient tumors. These findings reveal an epitranscriptomic vulnerability of VHL-deficient cells and identify a potential HIF-independent therapeutic target for ccRCC tumors.