Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

著者: Zobair M. Younossi, Vlad Ratziu, Rohit Loomba, Mary E. Rinella, Quentin M. Anstee, Zachary Goodman, Pierre Bédossa, Andreas Geier, Susanne Beckebaum, Philip N. Newsome, David Sheridan, Muhammad Y. Sheikh, James F. Trotter, W Knapple, Eric Lawitz, Manal F. Abdelmalek, Kris V. Kowdley, Aldo J. Montaño‐Loza, Jérôme Boursier, Philippe Mathurin, Elisabetta Bugianesi, G. Mazzella, Antonio Olveira, Helena Cortez‐Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean‐François Dufour, David E. Shapiro, Jason Campagna, Luna Zaru, Leigh MacConell, Reshma Shringarpure, Stephen A. Harrison, Arun J. Sanyal, Manal F. Abdelmalek, Gary A. Abrams, Humberto Aguilar, Aijaz Ahmed, Elmar Aigner, Guruprasad P. Aithal, Aftab Ala, William Alazawi, Agustı́n Albillos, Michael Allison, Sfa Al-Shamma, Raúl J. Andrade, Pietro Andreoné, M. Angélico, Victor Ankoma‐Sey, Quentin M. Anstee, Rodolphe Anty, Víctor Araya, Juan Ignacio Arenas Ruiz, Perttu Arkkila, Marty Arora, Tarik Asselah, Jennifer Au, Oyekoya T. Ayonrinde, Robert J. Bailey, Maya Balakrishnan, Kiran Bambha, Meena B. Bansal, Sidney Barritt, John Bate, Jorge Beato, Susanne Beckebaum, Jaideep Behari, Pablo Bellot, Ziv Ben Ari, Michael Bennett, Marina Berenguer, Benedetta Terziroli Beretta‐Piccoli, Thomas Berg, Maurizio Bonacini, Lucía Bonet, Brian B. Borg, Marc Bourlière, Jérôme Boursier, William D. Bowman, David Bradley, Marija Branković, Marius Braun, Jean-Pierre Bronowicki, Savino Bruno, Elisabetta Bugianesi, Cindy X. Cai, Amy Calderon, José Luis Calleja Panero, Elizabeth J. Carey, Michal Carmiel, J.A. Carrión, Matthew C. Cave, Cristina Chagas, Tawfik N. Chami, Alan K. Chang, Allan Coates, Jeremy Cobbold, Charlote Costentin, Kathleen E. Corey, Lynsey Corless, Helena Cortez‐Pinto, Javier Crespo, O. Pereira, Victor de Lédinghen, Andrew S. deLemos, M. Diago, Mamie Dong, Jean‐François Dufour, Predrag Dugalić, Winston Dunn, Magby Elkhashab, Michael Epstein, Maria Desamparados Escudero-García, Ohad Etzion, Larry Evans, Robert E. Falcone, Conrado Fernández‐Rodríguez, José Carlos Ferreira, Scott Fink, Kevin T. Finnegan, Roberto Firpi-Morell, Annarosa Floreani, Thierry Fontanges, Ryan Ford, Ewan Forrest, Andrew Fowell, Anna Ludovica Fracanzani, Sven Francque, B. Freilich, Juan P. Frías, Michael Fuchs, Javier Fuentes, Michael Galambos, Juan Gallegos, Anja Geerts, Andreas Geier, Jacob George, Maged P. Ghali, Reem Ghalib, Pierre Gholam, Pere Ginès, Norman Gitlin, Lise Lotte Gluud, Tobias Goeser, John S. Goff, Stuart C. Gordon, Frederic Gordon, Odile Goria, Shaun Greer, А В Григорян, Henning Grønbæk, Maéva Guillaume, Naresh T. Gunaratnam, Dina Halegoua‐De Marzio, Bilal Hameed, S Hametner, James Hamilton, Stephen Harrison, Marek Hartleb, Tarek Hassanein, Dieter Häussinger, Paul Hellstern, Robert Herring, Eva Heurich, Christophe Hezode, Holger Hinrichsen, Peter Holland Fischer, Yves Horsmans, Jonathan Huang, Hyder Hussaini, Antoine Jakiche, Lennox Jeffers, Blake Jones, Rosa Jorge, Francisco Jorquera, Shoba Joshi, Alişan Kahraman, Kelly Kaita, N C Karyotakis, Zeid Kayali, Stergios Kechagias, Thomas Kepczyk, Mandana Khalili, Hicham Khallafi, Johannes Kluwe, W Knapple, Anita Kohli, Kevin Korenblat, Kris V. Kowdley, Aleksander Krag, Richard A. Krause, Andreas E. Kremer, Karen Krok, Miodrag Krstić, Marcelo Kugelmas, Sonal Kumar, Scott K. Kuwada, Damien Labarrière, Michelle Lai, Wim Laleman, Pietro Lampertico, Eric Lawitz, Alice Lee, Vincent Leroy, Steven D. Lidofsky, Tina Huey Lim, Joseph K. Lim, Donald Lipkis, Ester C. Little, A. Di Lonardo, Michelle T. Long, Rohit Loomba, Velimir A. Luketic, Yoav Lurie, Guilherme Macedo, Joana Magalhães, Mihály Makara, Benedict Maliakkal, Michael Manns, Pinelopi Manousou, Parvez Mantry, Giulio Marchesini, Carla Marinho, Paul Marotta, Hanns–Ulrich Marschall, Linda Sprague Martínez, Philippe Mathurin, Marlyn J. Mayo, G. Mazzella, M. McCullen, William McLaughlin, Uta Merle, Raphael B. Merriman, Apurva A. Modi, Esther Molina, Aldo J. Montaño‐Loza, Carlos Monteverde, A. Cardona, Sulleman Moreea, Christophe Moreno, Filomena Morisco, Abdullah Mubarak, Beat Muellhaupt, Sandeep Mukherjee, Tobias Müller, Aleksandar Nagorni, Jahnavi Naik, Guy Neff, Moises I. Nevah, Philip N. Newsome, Éric Nguyen-Khac, Mazen Noureddin, Jude A. Oben, Antonio Olveira, Hans Orlent, David Orr, James Orr, Grisell Ortiz‐Lasanta, Violaine Ozenne, Prashant Pandya, Angelo H. Paredes, James Park, Joykumar Patel, Keyur P. Patel, Sonali Paul, Heather Patton, Markus Peck‐Radosavljevic, Salvatore Petta, Stephen Pianko, Anna Piekarska, Neville R. Pimstone, Joseph R. Pisegna, Paul J. Pockros, Stanislas Pol, Michael K. Porayko, John Poulos, David Pound, Joe Pouzar, José Presa Ramos, Nikolaos Pyrsopoulos, Nila Rafiq, Kate Muller, Alnoor Ramji, Vlad Ratziu, Ravi Ravinuthala, Chakradhar Reddy, Gautham Reddy K G, K. Rajender Reddy K R, Frederic Regenstein, Robert Reindollar, Justin Reynolds, Andrés Ricardo Pérez‐Riera, Mary E. Rinella, Jose Rivera Acosta, Geert Robaeys, Stuart K. Roberts, Federico Rodríguez-Pérez, Sandor Romero, Manuel Romero‐Gómez, Raymond A. Rubin, Maria Grazia Rumi, Simon Rushbrook, Christian Rust, Michael Ryan, Rifaat Safadi, Adnan Said, Kimmo Salminen, Didier Samuel, J. Santoro, Arun J. Sanyal, Souvik Sarkar, Cynthia Schaeffer, Jörn M. Schattenberg, Ingolf Schiefke, Eugene R. Schiff, Wolfgang E. Schmidt, Jeffrey Schneider, Jeoffrey Schouten, Michael Schultz, Giada Sebastiani, David Semela, Thomas Sepe, Aasim Sheikh, Muhammad Y. Sheikh, David Sheridan, Kenneth E. Sherman, Oren Shibolet, Mitchell L. Shiffman, Asma Siddique, Cyril Sieberhagen, Samuel H. Sigal, Katarzyna Sikorska, Krzysztof Simon, Marie Sinclair, Richard Skoien, Joel Solis, Siddharth Sood, Bob Souder, James R. Spivey, Per Stål, Laura M. Stinton, Simone I. Strasser, Petar Svorcan, Gyongzi Szabo, Andrew H. Talal, Edward Tam, Brent A. Tetri, Paul J. Thuluvath, Hillel Tobias, Krzysztof Tomasiewicz, Dawn M. Torres, Albert Tran, Michael Trauner, Christian Trautwein, James F. Trotter, Emanuel Tsochatzis, Esther Unitt, Vı́ctor Vargas, István Várkonyi, Ella Veitsman, Umberto Vespasiani‐Gentilucci, D. A. Victor, John M. Vierling, Catherine Vincent, Áron Vincze, Manfred von der Ohe, Natasha Von Roenn, Raj Vuppalanchi, Michael F. Waters, Kymberly D. Watt, Julia Wattacheril, Martin Weltman, Amanda Wieland, Gregory Wiener, Alonzo Williams A, Jeffrey Williams J, Jason Wilson, Maria Yataco, Eric M. Yoshida, Ziad Younes, Liyun Yuan, Adam Zivony, Donald L. Zogg, Heinz Zoller, Fabien Zoulim, Eli Zuckerman, Massimo Zuin - The Lancet 2019 被引用: 1,213