IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder

著者: Irene Tsilioni, Harry Pantazopoulos, Pio Conti, Susan E. Leeman, Theoharis C. Theoharides - Proceedings of the National Academy of Sciences, PNAS 2020 被引用: 43

Significance These findings indicate the important role of IL-38 in the inihibition of neurotensin-stimulated activation of microglia and the resulting release of proinflammatory molecules. Moreover, the reduced expression of IL-38 in the amygdala indicates that it may not be sufficient to prevent inflammation, and that its administration could serve as a novel treatment for children with autism spectrum disorder.