Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia

著者: Akitoshi Nakashima, Shi‐Bin Cheng, Masahito Ikawa, Tamotsu Yoshimori, Warren J. Huber, Ramkumar Menon, Zheping Huang, Jamie Fierce, James F. Padbury, Yoel Sadovsky, Shigeru Saito, Surendra Sharma - Autophagy 2019 被引用: 121

: autophagy related 7; CTSD: cathepsin D; ER: endoplasmic reticulum; EVTs: extravillous trophoblasts; KRT7: keratin 7; LAMP1: lysosomal associated membrane protein 1; LAMP2: lysosomal associated membrane protein 2; mSt: mStrawberry; MTORC1: mechanistic target of rapamycin complex 1; NP: normal pregnancy; NPS: normal pregnancy serum; PE: preeclampsia; PES: preeclampsia serum; p-RPS6KB: phosphorylated ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; TEM: transmission electron microscopy; TFEB: transcription factor EB; XPO1/CRM1: exportin 1.