Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine

著者: Jia Wen, Gilberto Padilla Mercado, Alyssa Volland, Heidi L. Doden, Colin R. Lickwar, Taylor Crooks, Genta Kakiyama, Cecelia Kelly, Jordan L. Cocchiaro, Jason M. Ridlon, John F. Rawls - Science Advances 2021 被引用: 80

bile acid that undergo multiple microbial modifications including bile acid deconjugation that augments Fxr activity. Using single-cell RNA sequencing, we provide a cellular atlas of the zebrafish intestinal epithelium and uncover roles for Fxr in transcriptional and differentiation programs in ileal and other cell types. These results establish zebrafish as a nonmammalian vertebrate model for studying bile salt metabolism and Fxr signaling.