The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

著者: Khalid El Bairi, Harry R. Haynes, Elizabeth F. Blackley, Susan Fineberg, Jeffrey Shear, Sophia Turner, Juliana Ribeiro de Freitas, Daniel Sur, Luis Claudio Amendola, Masoumeh Gharib, Amine Kallala, Indu Arun, Farid Azmoudeh Ardalan, Luciana Botinelly Mendonça Fujimoto, Luz F. Sua, Shiwei Liu, Huang‐Chun Lien, Pawan Kirtani, Marcelo Balancin, H. El Attar, Prerna Guleria, Wenxian Yang, Emad Shash, I‐Chun Chen, Verónica Bautista, José Fernando do Prado Moura, Bernardo L. Rapoport, Carlos Castaneda, Eunice Spengler, Gabriela Acosta-Haab, Isabel Frahm, Joselyn Sanchez, Miluska Castillo, Najat Bouchmaa, Reena R. Md Zin, Ruohong Shui, Timothy Onyuma, Wentao Yang, Zaheed Husain, Karen Willard‐Gallo, An Coosemans, Edith Perez, Elena Provenzano, Paula Gonzalez Ericsson, Eduardo Richardet, Ravi Mehrotra, Sandra Sarancone, Anna Ehinger, David L. Rimm, John M.S. Bartlett, Giuseppe Viale, Carsten Denkert, Akira I. Hida, Christos Sotiriou, Sibylle Loibl, Stephen M. Hewitt, Sunil Badve, W. Fraser Symmans, Rim S. Kim, Giancarlo Pruneri, Shom Goel, Prudence A. Francis, Gloria Inurrigarro, Rin Yamaguchi, Hernán Garcı́a Rivello, Hugo M. Horlings, Saïd Afqir, Roberto Salgado, Sylvia Adams, Marleen Kok, Maria Vittoria Dieci, Stefan Michiels, Sandra Demaria, Sherene Loi, The International Immuno-Oncology Biomarker Working Group, Khalid El Bairi, Harry R. Haynes, Elizabeth F. Blackley, Susan Fineberg, Jeffrey Shear, Sophia Turner, Juliana Ribeiro de Freitas, Daniel Sur, Luis Claudio Amendola, Masoumeh Gharib, Amine Kallala, Indu Arun, Farid Azmoudeh-Ardalan, Luciana Botinelly Mendonça Fujimoto, Luz F. Sua, Shiwei Liu, Huang‐Chun Lien, Pawan Kirtani, Marcelo Balancin, Hicham El Attar, Prerna Guleria, Wenxian Yang, Emad Shash, I‐Chun Chen, Veronica Bautista, Jose Fernando Do Prado Moura, Bernardo L. Rapoport, Carlos Castaneda, Eunice Spengler, Gabriela Acosta‐Haab, Isabel Frahm, Joselyn Sanchez, Miluska Castillo, Najat Bouchmaa, Reena R. Md Zin, Ruohong Shui, Timothy Onyuma, Wentao Yang, Zaheed Husain, Karen Willard‐Gallo, An Coosemans, Edith Perez, Elena Provenzano, Paula Gonzalez Ericsson, Eduardo Richardet, Ravi Mehrotra, Sandra Sarancone, Anna Ehinger, David L. Rimm, John M. S. Bartlett, Giuseppe Viale, Carsten Denkert, Akira I. Hida, Christos Sotiriou, Sibylle Loibl, Stephen M. Hewitt, Sunil Badve, William Fraser Symmans, Rim S. Kim, Giancarlo Pruneri, Shom Goel, Prudence A. Francis, Gloria Inurrigarro, Rin Yamaguchi, Hernán Garcı́a Rivello, Hugo Horlings, Saïd Afqir, Roberto Salgado, Sylvia Adams, Marleen Kok, Maria Vittoria Dieci, Stefan Michiels, Sandra Demaria, Sherene Loi, Vera Schelfhout, Elham Arbzadeh, Anastasiya Bondanar, Silvio Antonio Galeano Reyes, José Ramírez Ruz, Jun Kang, Xiang Lü, Martina Zimovjanová, Pilar Togores, Tülin Öztürk, Asawari Patil, Marcus Corpa, Ann Whitehouse, Benjamin Tan, Alfredo de Paula, Claudia Rossetti, Corinna Lang‐Schwarz, Sarah Mahon, Cinzia Giacometti, Barbro Linderholm, Frederik Deman, Giacomo Montagna, Gyungyub Gong, Marta Pavcovich, Yeesoo Chaer, Isabel Alvarado Cabrero, Mayana Lopes de Brito, Nevena Ilieva, Annamaria Fulop, Maiara Priscilla de Souza, Domenico Bilancia, Michael Idowu, Ritika Johri, Joanna Szpor, Lira Bachani, Fernando Schmitt, Mag Giannotti, Yutaka Kurebayashi, Bruno Elias Anota Ramirez, Eduardo Salido, Laura Bortesi, Sara Bonetto, Kevin Elomina, Patricia López, Vijay Sharma, Amalika Edirisinghe, Dhanvi Mathur, Ayushi Sahay, Makhlouf Ait Mouloud, Chau Giang, Edwin Mukolwe, Edgar Kiruka, Nancy L. Samberg, Norie Abe, Mark Brown, Ewan K.A. Millar, Xiaoxian Li, Yuan Zheng, Asokan Pasupathy, Raffaele Miele, Ronald D. Luff, Mônica Modesto Araújo e Porfírio, Ogugua Ajemba, Rashida Soni, Enrico Orvieto, Michael DiMaio, Jeremy Thomas, Reena Merard, Manish Mani Subramaniam, Thiago Apolinario, Ovidiu Preda, Ricardo Preda, Alexander Makanga, Marcelo do Rego Maciel Souto Maior, Lingyu Li, Mahasti Saghatchian, Tricia Saurine, Emiel A. M. Janssen, John H. Cochran, Nikitina Vlada, Rocco Cappellesso, Katherine Elfer, Morven Hollick, Sangeeta Desai, Gizem Öner, A. J. M. Schreurs, Steve Liu, Rashindrie Perera, Paola Mercurio, Felip Garcia, Kareem Hosny, Hirofumi Matsumoto, Carolien van Deurzen, Giampaolo Bianchini, İpek Çoban, Arif Jahangir, Arman Rahman, Daniel G. Stover, Paulo Luz, Anne Martel, Yannick Waumans, Albrecht Stenzinger, Javier Cortes, Polina Dimitrova, Inne Nauwelaers, Montse Velasco, Fang Fan, Güray Aktürk, Michael Firer, Ioannis Roxanis, Mary Schneck, Hannah Y. Wen, Vincent Cockenpot, Aleksei Konstantinov, Ana Calatrava, M. N. Vidya, Hyun Joo Choi, Paul Jank, Aini Hyyti ÇÏinen, Dhanusha Sabanathan, Giuseppe Floris, Doris Hoeflmayer, Tetsuo Hamada, Nele Laudus, Anita Grigoriadis, Ilaria Porcellato, Balázs Ács, Federica Miglietta, Jeannette Parrodi, David Clunie, Benjamin C. Calhoun, Fang‐I Lu, Alexis Lefevre, Sami Tabbarah, William T. Tran, Isaac García-Murillas, Petar Jelinic, Carolien Boeckx, Sandra C. Souza, MarÇða Cebollero, E. Felip, Jose Luis Solorzano Rendon, Ehab El Gabry, Joel Saltz, Emilio Bria, Giovanna Garufi, Johan Hartman, Manu Sebastian, Helena Olofsson, Loes Kooreman, Joël Cucherousset, Marie‐Christine Mathieu, Carmen Ballesteros‐Merino, Popi Siziopikou, Jacinta J Fong, Molly Klein, Ignasi Roig I. Qulis, Jelle Wesseling, Enrique Bellolio, Juan Carlos Araya, Stephen P. Naber, Maggie Cheang, Isabella Castellano, Ales Ales, Anne‐Vibeke Lænkholm, Janina Kulka, Cecily Quinn, Anna Sapino, Isabel Amendoeira, Caterina Marchiò, Jeremy Braybrooke, Anne Vincent-Salomon, Konstanty Korski, Michail Sofopoulos, Elisabeth Ida Specht Stovgaard, Simonetta Bianchi, Zsuzsanna Bagó-Horváth, Clare Yu, Peter Regitnig, Sean R. R. Hall, Zuzana Kos, Sneha Sant, Jean‐Christophe Tille, Brandon D. Gallas, Daniel Bethmann, Peter Savas, Larissa Mendes, Teresa Soler, Maartje van Seijen, Tina Gruosso, Angela Quintana, Jennifer M. Giltnane, Gert Van den Eynden, Eleonora Duregon, Rafael de Cabo, Phil Coates Recamo, Louis Gaboury, Johannes Zimmerman, C. Stanciu Pop, Alejandra Wernicke, David Williams, Anthony J. Gill, Benjamin Solomon, Bibhusal Thapa, Gelareh Farshid, Leslie Gilham, Michael Christie, Sandra A. O’Toole, Shona Hendry, Stephen B. Fox, Stephen J. Luen, Sunil R. Lakhani, Talia L. Fuchs, Tom John, Iva Brčić, Johannes A. Hainfellner, Sigurd Lax, Matthias Preusser, Philip Poortmans, Alex Decaluwe, Caroline Carey, Cécile Colpaert, Denis Larsimont, Dieter Peeters, Glenn Broeckx, Koen Van de Vijver, Laurence Buisseret, Luc Dirix, Marjan Hertoghs, Martine Piccart, Michail Ignatiadis, Mieke Van Bockstal, Nicolas Sirtaine, Peter Vermeulen, Roland de Wind, Sabine Declercq, Thomas Gevaert, Benjamin Haibe-Kans, Brad H. Nelson, Peter H. Watson, Sam Leung, Torsten O. Nielsen, Leming Shi, Eva Balslev, Jeppe Thagaard, Alhadi Almangush, Antti Mäkitie, Heikki Joensuu, Johan Lundin, Damien Drubay, Elvire Roblin, Fabrice André, Frédérique Penault‐Llorca, Jérôme Lemonnier, Julien Adam, Magali Lacroix‐Triki, Nils Ternès, Nina Radosevic‐Robin, Frederick Klaushen, Karsten E. Weber, Nadia Harbeck, Oleg Gluz, Stephan Wienert, Gábor Cserni, Andrea Vingiani, Carmen Criscitiello, Cinzia Solinas, Giuseppe Curigliano, Eiichi Konishi, Eiji Suzuki, Katsuhiro Yoshikawa, Kosuke Kawaguchi, Masahiro Takada, Masakazu Toi, Mitsuaki Ishida, Nobuhiro Shibata, Shigehira Saji, Takahiro Kogawa, Takashi Sakatani, Takeru Okamoto, Takuya Moriya, Tatsuki R. Kataoka, Tatsunori Shimoi, Tomohagu Sugie, Tomoharu Sugie, Toru Mukohara, Shu Yazaki, Yuichiro Kikawa, Yuji Kozuka, Shahin Sayed, Reena Rahayu, Reena Ramsaroop, Elżbieta Senkus, Ewa Chmielik, Fátima Cardoso, Joana Ribeiro, Jack Junjie Chan, Rebecca Dent, Miguel Martín, Carlos Hagen, Ángel Guerrero, Federico Rojo, Laura Comerma, Paolo Nucíforo, Victor Vivo Serrano, Vincente Peg Cámaea, Tessa G. Steenbruggen, Francesco Ciompi, Iris Nederlof, Jan Hudecek, Jeroen van der Laak, José van den Berg, Leonie Voorwerk, Mark van de Vijver, Michiel de Maaker, Sabine C. Linn, Hayley McKenzie, Navita Somaiah, Andrew Tutt, Charles Swanton, Crispin T. Hiley, David A. Moore, Jacqueline A. Hall, John Le Quesne, Khalid Abdul Jabbar, Maise Al Bakir, Robert K. Hills, Sheeba Irshad, Yinyin Yuan, Zaibo Li, Minetta C. Liu, Jonathan Klein, Oluwole Fadare, Alastair M. Thompson, Alexander J. Lazar, Allen M. Gown, Amy Lo, Ana C. Garrido Castro, Anant Madabhushi, André Moreira, Andrea L. Richardson, Andrew H. Beck, Andrew M. Bellizzi, Antonio C. Wolff, Aparna Harbhajanka, Ashish Sharma, Ashley Cimino‐Mathews, Ashok Srinivasan, Baljit Singh, Chakra S. Chennubhotla, Cynthia Chauhan, Deborah Dillon, Dimitrios Zardavas, Douglas B. Johnson, Aubrey Thompson, Edi Brogi, Emily Reisenbichler, Erich Huang, Fred R. Hirsch, Heather L. McArthur, James Ziai, Jane Brock, Jennifer K. Kerner, Jiping Zha, Jochen K. Lennerz, Jodi M. Carter, Jorge S. Reis‐Filho, Joseph A. Sparano, Justin M. Balko, Katherine L. Pogue–Geile, Keith E. Steele, Kim Blenman, Kimberly H. Allison, Lajos Pusztai, Lee Cooper, Valeria M. Estrada, Margaret Flowers, Mark E. Robson, Marlon C. Rebelatto, Matthew G. Hanna, Matthew P. Goetz, Mehrnoush Khojasteh, Melinda E. Sanders, Meredith M. Regan, Michael J. Misialek, Mohamed Amgad, Nadine Tung, Rajendra Singh, Richard S.P. Huang, Robert H. Pierce, Roberto A. Leon‐Ferre, Sandra M. Swain, Scott Ely, Seong-Rim Kim, Shahinaz Bedri, Soonmyung Paik, Stuart J. Schnitt, Timothy d’Alfons, Uday Kurkure, Veerle Bossuyt, Weida Tong, Yihong Wang, Carlos Henrique dos Anjos, Fabien Gaire, Paul J. van Diest - npj Breast Cancer 2021 被引用: 275

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC.