Traceless Ligation of Cysteine Peptides Using Selective Deselenization

著者: Norman Metanis, Ehud Keinan, Philip E. Dawson - Angewandte Chemie International Edition 2010 被引用: 214

Selective deselenization: Native chemical ligation at selenocysteine is followed by selective deselenization of the selenocysteine to alanine, in the presence of cysteine residues without protecting groups (see scheme). This selectivity is achieved by using the water-soluble tris(2-carboxyethyl)phosphine (TCEP) in the absence of a radical initiator.