Charles A. Gersbach
Active 2004–2025
- 87
- Papers
- 21,962
- Citations
- 65
- h-index
- 81
- i10-index
Citations
Citation sources
Countries
Institutions
- Harvard University1.4%
- Howard Hughes Medical Institute0.9%
- Chinese Academy of Sciences0.9%
- Duke University0.8%
- Stanford University0.8%
- Broad Institute0.7%
- Other94.5%
Fields
- Biochemistry, Genetics and Molecular Biology79.1%
- Medicine11.1%
- Neuroscience2.5%
- Agricultural and Biological Sciences2.4%
- Engineering1.5%
- Immunology and Microbiology1.4%
- Other2%
Topics
- CRISPR and Genetic Engineering19.3%
- RNA Interference and Gene Delivery4.1%
- Advanced biosensing and bioanalysis techniques3.8%
- Virus-based gene therapy research3.8%
- RNA and protein synthesis mechanisms3.7%
- Pluripotent Stem Cells Research2.9%
- Other62.4%
Coauthors
- Timothy E. Reddy16
- Gregory E. Crawford14
- Alejandro Barrera13
- Aravind Asokan10
- David G. Ousterout10
- Pratiksha I. Thakore10
- Farshid Guilak9
- Ami M. Kabadi8
- Christopher E. Nelson8
- Pablo Pérez‐Piñera8
- Alexias Safi7
- Lingyun Song7
- Christopher M. Vockley6
- D. Dewran Koçak6
- Isaac B. Hilton6
- Jonathan M. Brunger6
- Joshua B. Black6
- Nahid Iglesias6
- William H. Majoros6
- Adrian Pickar‐Oliver5
- Andrés J. Garcı́a5
- Anthony D’Ippolito5
- Lexi R. Bounds5
- Luke C. Bartelt5
All papers
- The next generation of CRISPR–Cas technologies and applications
Authors: Adrian Pickar‐Oliver, Charles A. Gersbach - Nature Reviews Molecular Cell Biology 2019 cited by 1,493
- ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
Authors: Thomas Gaj, Charles A. Gersbach, Carlos F. Barbas - Trends in biotechnology 2013 cited by 3,774
- Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
Authors: Isaac B. Hilton, Anthony D’Ippolito, Christopher M. Vockley, Pratiksha I. Thakore, Gregory E. Crawford, Timothy E. Reddy, Charles A. Gersbach - Nature Biotechnology 2015 cited by 1,876
- RNA-guided gene activation by CRISPR-Cas9–based transcription factors
Authors: Pablo Pérez‐Piñera, D. Dewran Koçak, Christopher M. Vockley, Andrew F. Adler, Ami M. Kabadi, Lauren R. Polstein, Pratiksha I. Thakore, Katherine A. Glass, David G. Ousterout, Kam W. Leong, Farshid Guilak, Gregory E. Crawford, Timothy E. Reddy, Charles A. Gersbach - Nature Methods 2013 cited by 1,349
- Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
Authors: Pratiksha I. Thakore, Anthony D’Ippolito, Lingyun Song, Alexias Safi, Nishkala K. Shivakumar, Ami M. Kabadi, Timothy E. Reddy, Gregory E. Crawford, Charles A. Gersbach - Nature Methods 2015 cited by 1,045
- The once and future gene therapy
Authors: Karen Bulaklak, Charles A. Gersbach - Nature Communications 2020 cited by 322
- In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
Authors: Christopher E. Nelson, Chady H. Hakim, David G. Ousterout, Pratiksha I. Thakore, Eirik A. Moreb, Ruth M. Castellanos Rivera, Sarina Madhavan, Xiufang Pan, F. Ann Ran, Winston X. Yan, Aravind Asokan, Feng Zhang, Dongsheng Duan, Charles A. Gersbach - Science 2015 cited by 1,152
- Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy
Authors: Christopher E. Nelson, Yaoying Wu, Matthew Gemberling, Matthew L. Oliver, Matthew A. Waller, Joel D. Bohning, Jacqueline N. Robinson-Hamm, Karen Bulaklak, Ruth M. Castellanos Rivera, Joel H. Collier, Aravind Asokan, Charles A. Gersbach - Nature Medicine 2019 cited by 429
- Increasing the specificity of CRISPR systems with engineered RNA secondary structures
Authors: D. Dewran Koçak, Eric A. Josephs, Vidit Bhandarkar, Shaunak Adkar, Jennifer B. Kwon, Charles A. Gersbach - Nature Biotechnology 2019 cited by 361
- Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models
Authors: Chady H. Hakim, Sandeep Kumar, Dennis O. Pérez‐López, Nalinda B. Wasala, Dong Zhang, Yongping Yue, James Teixeira, Xiufang Pan, Keqing Zhang, Emily D. Million, Christopher E. Nelson, Samantha Metzger, Jin-Young Han, Jacqueline A. Louderman, Florian Schmidt, Feng Feng, Dirk Grimm, B. F. Smith, Gang Yao, N. Nora Yang, Charles A. Gersbach, Shi‐Jie Chen, Roland W. Herzog, Dongsheng Duan - Nature Communications 2021 cited by 170
- Editing the epigenome: technologies for programmable transcription and epigenetic modulation
Authors: Pratiksha I. Thakore, Joshua B. Black, Isaac B. Hilton, Charles A. Gersbach - Nature Methods 2016 cited by 448
- Genome-editing Technologies for Gene and Cell Therapy
Authors: Morgan L. Maeder, Charles A. Gersbach - Molecular Therapy 2016 cited by 718
- A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
Authors: Lauren R. Polstein, Charles A. Gersbach - Nature Chemical Biology 2015 cited by 651
- CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome
Authors: Tyler S. Klann, Joshua B. Black, Malathi Chellappan, Alexias Safi, Lingyun Song, Isaac B. Hilton, Gregory E. Crawford, Timothy E. Reddy, Charles A. Gersbach - Nature Biotechnology 2017 cited by 470
- Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens
Authors: Sean R. McCutcheon, Adam M. Swartz, Michael C. Brown, Alejandro Barrera, Christian McRoberts Amador, Keith Siklenka, Lucas Humayun, Maria A. ter Weele, James Isaacs, Timothy E. Reddy, Andrew S. Allen, Smita K. Nair, Scott J. Antonia, Charles A. Gersbach - Nature Genetics 2023 cited by 78
- Transgenic mice for in vivo epigenome editing with CRISPR-based systems
Authors: Matthew Gemberling, Keith Siklenka, Erica Rodriguez, Katherine R. Tonn Eisinger, Alejandro Barrera, Fang Liu, Ariel Kantor, Liqing Li, Valentina Cigliola, Mariah F. Hazlett, Courtney Williams, Luke C. Bartelt, Victoria J. Madigan, Josephine C. Bodle, Heather Daniels, Douglas Rouse, Isaac B. Hilton, Aravind Asokan, Maria Ciofani, Kenneth D. Poss, Timothy E. Reddy, Anne E. West, Charles A. Gersbach - Nature Methods 2021 cited by 138
- Epigenome editing technologies for discovery and medicine
Authors: Sean R. McCutcheon, Dahlia Rohm, Nahid Iglesias, Charles A. Gersbach - Nature Biotechnology 2024 cited by 95
- Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing
Authors: Trevor Gonzalez, Katherine E. Simon, Leo O. Blondel, Marco M. Fanous, Angela L. Roger, Maribel Santiago Maysonet, Garth Devlin, Timothy J. Smith, Daniel K. Oh, L. Patrick Havlik, Ruth M. Castellanos Rivera, Jorge A. Piedrahita, Mai K. ElMallah, Charles A. Gersbach, Aravind Asokan - Nature Communications 2022 cited by 81
- Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector
Authors: Ami M. Kabadi, David G. Ousterout, Isaac B. Hilton, Charles A. Gersbach - Nucleic Acids Research 2014 cited by 388
- RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
Authors: Pratiksha I. Thakore, Jennifer B. Kwon, Christopher E. Nelson, Douglas Rouse, Matthew Gemberling, Matthew L. Oliver, Charles A. Gersbach - Nature Communications 2018 cited by 174
- Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes
Authors: Liang-Fu Chen, Yen Ting Lin, David A. Gallegos, Mariah F. Hazlett, Mariana Gómez-Schiavon, Marty G. Yang, Breanna Kalmeta, Allen S. Zhou, Liad Holtzman, Charles A. Gersbach, Jörg Grandl, Nicolas E. Buchler, Anne E. West - Cell Reports 2019 cited by 177
- Multicenter integrated analysis of noncoding CRISPRi screens
Authors: David Yao, Josh Tycko, Jin Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D. White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J. Greenleaf, Pardis C. Sabeti, Christina S. Leslie, Yuri Pritykin, Jill E. Moore, M Beer, Charles A. Gersbach, Timothy E. Reddy, Yin Shen, J Engreitz, Michael C. Bassik, Steven K. Reilly - Nature Methods 2024 cited by 50
- Full-length dystrophin restoration via targeted exon integration by AAV-CRISPR in a humanized mouse model of Duchenne muscular dystrophy
Authors: Adrian Pickar‐Oliver, Veronica Gough, Joel D. Bohning, Siyan Liu, Jacqueline N. Robinson-Hamm, Heather Daniels, William H. Majoros, Garth Devlin, Aravind Asokan, Charles A. Gersbach - Molecular Therapy 2021 cited by 67
- Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
Authors: Jacquelyn M. Walejko, Bridgette A. Christopher, Scott B. Crown, Guofang Zhang, Adrian Pickar‐Oliver, Takeshi Yoneshiro, Matthew W. Foster, Stephani C. Page, Stephan van Vliet, Olga Ilkayeva, Michael J. Muehlbauer, Matthew W. Carson, Joseph T. Brozinick, Craig D. Hammond, Ruth E. Gimeno, M. Arthur Moseley, Shingo Kajimura, Charles A. Gersbach, Christopher B. Newgard, Phillip J. White, Robert W. McGarrah - Nature Communications 2021 cited by 97
