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Christian Klein

Active 1995–2026

250
Papers
30,876
Citations
87
h-index
209
i10-index

Citations

Citations per year for Christian Klein1995: 1 citations1996: 2 citations1997: 3 citations1999: 5 citations2000: 6 citations2001: 14 citations2002: 13 citations2003: 40 citations2004: 90 citations2005: 145 citations2006: 189 citations2007: 163 citations2008: 187 citations2009: 200 citations2010: 224 citations2011: 233 citations2012: 194 citations2013: 235 citations2014: 269 citations2015: 255 citations2016: 240 citations2017: 275 citations2018: 312 citations2019: 877 citations2020: 1,063 citations2021: 1,366 citations2022: 1,125 citations2023: 977 citations2024: 1,699 citations2025: 988 citations2026: 38 citations1998: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 3,594 citing papers, 23.9% of this breakdownChina: 1,869 citing papers, 12.5% of this breakdownGermany: 1,282 citing papers, 8.5% of this breakdownUnited Kingdom: 967 citing papers, 6.4% of this breakdownFrance: 667 citing papers, 4.4% of this breakdownSwitzerland: 654 citing papers, 4.4% of this breakdownItaly: 625 citing papers, 4.2% of this breakdownNetherlands: 437 citing papers, 2.9% of this breakdownAustralia: 390 citing papers, 2.6% of this breakdownSpain: 390 citing papers, 2.6% of this breakdownJapan: 370 citing papers, 2.5% of this breakdownCanada: 351 citing papers, 2.3% of this breakdown
0%23.9%Other 22.8%

Institutions

Fields

  • Medicine57.6%
  • Biochemistry, Genetics and Molecular Biology18.7%
  • Immunology and Microbiology9.6%
  • Computer Science5.1%
  • Engineering1.9%
  • Neuroscience1.3%
  • Other5.8%

Topics

  • CAR-T cell therapy research5.1%
  • Cancer Immunotherapy and Biomarkers4.9%
  • Monoclonal and Polyclonal Antibodies Research3.8%
  • Immune Cell Function and Interaction3.6%
  • Immunotherapy and Immune Responses3.6%
  • Cancer-related Molecular Pathways3.5%
  • Other75.5%

Coauthors

All papers

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  1. A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

    Authors: Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, Andreas Roller, Marcel P. Trefny, Sarah Dimeloe, Anna Kiialainen, Jonathan Hanhart, Catherine Schill, Christoph Hess, Spasenija Savic Prince, Mark Wiese, Didier Lardinois, Ping‐Chih Ho, Christian Klein, Vaios Karanikas, Kirsten D. Mertz, Ton N. Schumacher, Alfred Zippelius - Nature Medicine 2018 cited by 1,187

  2. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

    Authors: Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves, Daisy Carvajal, Frank Podlaski, Zoran Filipovic, Norman Kong, U. Kammlott, Christine Lukacs, Christian Klein, Nader Fotouhi, Emily A. Liu - Science 2004 cited by 4,710

  3. The present and future of bispecific antibodies for cancer therapy

    Authors: Christian Klein, Ulrich Brinkmann, Janice M. Reichert, Roland E. Kontermann - Nature Reviews Drug Discovery 2024 cited by 421

  4. PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

    Authors: Masao Hashimoto, Koichi Araki, Maria A. Cardenas, Peng Li, Rohit R. Jadhav, Haydn Kissick, William Henry Hudson, Donald J. McGuire, Rebecca C. Obeng, Andreas Wieland, Judong Lee, Daniel T. McManus, James Ross, Se Jin Im, Junghwa Lee, Jian‐Xin Lin, Bin Hu, Erin E. West, Christopher D. Scharer, Gordon J. Freeman, Arlene H. Sharpe, Suresh S. Ramalingam, Alex Pellerin, Volker Teichgräber, William J. Greenleaf, Christian Klein, Jörg J. Goronzy, Pablo Umaña, Warren J. Leonard, Kendall A. Smith, Rafi Ahmed - Nature 2022 cited by 321

  5. PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

    Authors: Laura Codarri Deak, Valeria Nicolini, Masao Hashimoto, Maria Karagianni, Petra Schwalie, Laura Lauener, Eleni Maria Varypataki, Marine Richard, Esther Bommer, Johannes Sam, Stefanie Joller, Mario Perro, Floriana Cremasco, Leo Kunz, Emilio Yángüez, Tamara Hüsser, Ramona Schlenker, Marisa Mariani, Vinko Toševski, Sylvia Herter, Marina Bacac, Inja Waldhauer, Sara Colombetti, Xavier Guéripel, Stephan Wullschleger, Mélanie Tichet, Douglas Hanahan, Haydn Kissick, Stéphane Leclair, Anne Freimoser–Grundschober, Stefan Seeber, Volker Teichgräber, Rafi Ahmed, Christian Klein, Pablo Umaña - Nature 2022 cited by 268

  6. Ångström-resolution fluorescence microscopy

    Authors: S. Reinhardt, Luciano A. Masullo, Isabelle Pachmayr, Philipp R. Steen, Rafal Kowalewski, Alexandra S. Eklund, Sebastian Strauss, Eduard M. Unterauer, Thomas Schlichthaerle, Maximilian T. Strauss, Christian Klein, Ralf Jungmann - Nature 2023 cited by 298

  7. Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy

    Authors: Maud Mayoux, Andreas Roller, Vesna Pulko, Stefano Sammicheli, Stanford Chen, Eva Sum, Christian Jöst, Marieke F. Fransen, Regula B. Buser, Marcin Kowanetz, Karolin Rommel, Ines Matos, Sara Colombetti, Anton Belousov, Vaios Karanikas, Ferry Ossendorp, Priti S. Hegde, Daniel S. Chen, Pablo Umaña, Mario Perro, Christian Klein, Wei Xu - Science Translational Medicine 2020 cited by 380

  8. Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases

    Authors: Jörg T. Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A. Barathi, Chui Ming Gemmy Cheung, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostálek, Jörg Moelleken, Kay Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael Koss, Christian Klein, David T. Shima, Guido Hartmann - EMBO Molecular Medicine 2016 cited by 359

  9. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxicity

    Authors: Ekkehard Mössner, Peter Brünker, Samuel Moser, Ursula Püntener, Carla Schmidt, Sylvia Herter, Roger Grau, Christian Gerdes, Adam Nopora, Erwin van Puijenbroek, Claudia Ferrara, Peter Sondermann, Christiane Jäger, Pamela Strein, Georg Fertig, Thomas Friess, Christine Schüll, Sabine Bauer, Joseph Dal Porto, Christopher Del Nagro, Karim Dabbagh, Martin J.S. Dyer, Sibrand Poppema, Christian Klein, Pablo Umaña - Blood 2010 cited by 957

  10. CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies

    Authors: Marina Bacac, Sara Colombetti, Sylvia Herter, Johannes Sam, Mario Perro, Stanford Chen, Roberta Bianchi, Marine Richard, Anne Schoenle, Valeria Nicolini, Sarah Diggelmann, Florian Limani, Ramona Schlenker, Tamara Hüsser, W. Richter, Katharine Bray‐French, Heather Hinton, Anna Maria Giusti, Anne Freimoser–Grundschober, Laurent Larivière, Christiane Neumann, Christian Klein, Pablo Umaña - Clinical Cancer Research 2018 cited by 238

  11. Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions

    Authors: Tilman Schlothauer, Sylvia Herter, Claudia Ferrara, Sandra Grau-Richards, Virginie Steinhart, Christian Spick, Manfred Kubbies, Christian Klein, Pablo Umaña, Ekkehard Mössner - Protein Engineering Design and Selection 2016 cited by 419

  12. Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

    Authors: Mélanie Tichet, Stephan Wullschleger, Agnieszka Chryplewicz, Nadine Fournier, Rachel Marcone, Annamaria Kauzlaric, Krisztián Homicskó, Laura Codarri Deak, Pablo Umaña, Christian Klein, Douglas Hanahan - Immunity 2023 cited by 128

  13. Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker

    Authors: Flavio Solca, G. Dahl, Andreas Zoephel, Gerd Bader, Michael P. Sanderson, Christian Klein, Oliver Kraemer, Frank Himmelsbach, Eric Haaksma, Guenther R. Adolf - Journal of Pharmacology and Experimental Therapeutics 2012 cited by 867

  14. Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

    Authors: Wolfgang Schäfer, Jörg T. Regula, Monika Bähner, Jürgen Schanzer, Rebecca Croasdale, Harald Dürr, Christian Gassner, Guy Georges, Hubert Kettenberger, Sabine Imhof-Jung, Manfred Schwaiger, Kay Stubenrauch, Claudio Sustmann, Markus Thomas, Werner Scheuer, Christian Klein - National Academy of Sciences, Proceedings of the National Academy of Sciences 2011 cited by 479

  15. A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

    Authors: Marina Bacac, Tanja Fauti, Johannes Sam, Sara Colombetti, Tina Weinzierl, Djamila Ouaret, Walter F. Bodmer, Steffi Lehmann, Thomas Höfer, Ralf J. Hosse, Ekkehard Moessner, Oliver Ast, Peter Bruenker, Sandra Grau-Richards, Teilo Schaller, Annette Seidl, Christian Gerdes, Mario Perro, Valeria Nicolini, Nathalie Steinhoff, Sherri Dudal, Sebastian Neumann, Thomas von Hirschheydt, Christiane Jaeger, Jose Saro, Vaios Karanikas, Christian Klein, Pablo Umaña - Clinical Cancer Research 2016 cited by 355

  16. Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines

    Authors: Christian Klein, Inja Waldhauer, Valeria Nicolini, Anne Freimoser–Grundschober, Tapan K. Nayak, Daniëlle J. Vugts, Claire Dunn, Marije Bolijn, Jörg Benz, M. Stihle, Sabine M. Lang, Michaele Roemmele, Thomas Höfer, Erwin van Puijenbroek, David Wittig, Samuel Moser, Oliver Ast, Peter Brünker, Ingo H. Gorr, Sebastian Neumann, Maria Cristina De Vera Mudry, Heather Hinton, Flavio Crameri, Jose Saro, Stefan Evers, Christian Gerdes, Marina Bacac, Guus A.M.S. van Dongen, Ekkehard Moessner, Pablo Umaña - OncoImmunology 2017 cited by 283

  17. The Influence of Firm Size on the ESG Score: Corporate Sustainability Ratings Under Review

    Authors: Samuel Drempetic, Christian Klein, Bernhard Zwergel - Journal of Business Ethics 2019 cited by 1,446

  18. Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

    Authors: Christina Claus, Claudia Ferrara, Wei Xu, Johannes Sam, Sabine M. Lang, Franziska Uhlenbrock, R. Albrecht, Sylvia Herter, Ramona Schlenker, Tamara Hüsser, Sarah Diggelmann, John Challier, Ekkehard Mössner, Ralf J. Hosse, Thomas Höfer, Peter Brünker, Catherine Joseph, Jörg Benz, Philippe Ringler, Henning Stahlberg, Matthias E. Lauer, Mario Perro, Stanford Chen, Christine Küttel, Preethi Latha Bhavani Mohan, Valeria Nicolini, Martina Birk, Amandine Ongaro, Christophe Prince, Reto Gianotti, Gregory O. Dugan, Christopher T. Whitlow, Kiran Kumar Solingapuram Sai, David L. Caudell, Armando G. Burgos-Rodríguez, J. Mark Cline, Michael Hettich, Maurizio Ceppi, Anna Maria Giusti, Flavio Crameri, Wouter H. P. Driessen, Peter N. Morcos, Anne Freimoser–Grundschober, Victor Levitsky, Maria Amann, Sandra Grau-Richards, Thomas von Hirschheydt, Stella Tournaviti, Michael Mølhøj, Tanja Fauti, Viola Heinzelmann‐Schwarz, Volker Teichgräber, Sara Colombetti, Marina Bacac, Alfred Zippelius, Christian Klein, Pablo Umaña - Science Translational Medicine 2019 cited by 266

  19. Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma

    Authors: Edward K. Geissler, Andreas A. Schnitzbauer, C. Zülke, P. Lamby, Andrea Proneth, Christophe Duvoux, Patrizia Burra, Karl‐Walter Jauch, Markus Rentsch, Tom M. Ganten, Jan Schmidt, Utz Settmacher, Michael Heise, G. Rossi, Umberto Cillo, Norman M. Kneteman, René Adam, Bart van Hoek, Philippe Bachellier, Philippe Wolf, Lionel Rostaing, Wolf O. Bechstein, Magnus Rizell, James J. Powell, Ernest Hidalgo, Jean Gugenheim, Heiner Wolters, Jens Brockmann, André Roy, Ingrid Mutzbauer, Angela Schlitt, Susanne Beckebaum, Christian Graeb, Silvio Nadalin, Umberto Valente, Víctor Sánchez Turrión, Neville V. Jamieson, Tim Scholz, M. Colledan, Fred Fändrich, Thomas Becker, Gunnar Söderdahl, Olivier Chazouillères, Heikki Mäkisalo, Georges‐Philippe Pageaux, Rudolf Steininger, Thomas Soliman, Koert P. de Jong, Jacques Pirenne, Raimund Margreiter, Johann Pratschke, Antonio D. Pinna, Johann Hauss, Stefan Schreiber, Simone I. Strasser, Jürgen Klempnauer, Roberto Troisi, Sherrie Bhoori, Jan Lerut, Itxarone Bilbao, Christian Klein, Alfred Königsrainer, Darius F. Mirza, Gerd Otto, Vincenzo Mazzaferro, P. Neuhaus, Hans J. Schlitt - Transplantation 2015 cited by 417

  20. Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors

    Authors: Daniela S. Thommen, Jens Schreiner, Philipp Müller, Petra Herzig, Andreas Roller, Anton Belousov, Pablo Umaña, Pavel Pisa, Christian Klein, Marina Bacac, Ozana S. Fischer, Wolfgang Moersig, Spasenija Savic Prince, Victor Levitsky, Vaios Karanikas, Didier Lardinois, Alfred Zippelius - Cancer Immunology Research 2015 cited by 381

  21. Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy

    Authors: Inja Waldhauer, Valeria Gonzalez‐Nicolini, Anne Freimoser–Grundschober, Tapan K. Nayak, Linda Fahrni, Ralf J. Hosse, Danny Gerrits, E.J. Geven, Johannes Sam, Sabine M. Lang, Esther Bommer, Virginie Steinhart, Elisabeth Husar, Sara Colombetti, Erwin van Puijenbroek, Markus Neubauer, J. Mark Cline, Pradeep Garg, Gregory O. Dugan, Federica Cavallo, Gonzalo Acuña, Jehad Charo, Volker Teichgräber, Stefan Evers, Otto C. Boerman, Marina Bacac, Ekkehard Moessner, Pablo Umaña, Christian Klein - mAbs 2021 cited by 118

  22. The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy

    Authors: Christina Claus, Claudia Ferrara, Christian Klein - mAbs 2023 cited by 101

  23. Target Expression, Generation, Preclinical Activity, and Pharmacokinetics of the BCMA-T Cell Bispecific Antibody EM801 for Multiple Myeloma Treatment

    Authors: Anja Seckinger, Jose Antonio Delgado, Samuel Moser, Laura Moreno, Brigitte Neuber, Anna Luise Grab, Susanne Lipp, Juana Merino, Felipe Prósper, Martina Emde, Camille Delon, Melanie Latzko, Reto Gianotti, Remo Lüoend, Ramona Murr, Ralf J. Hosse, Lydia Jasmin Harnisch, Marina Bacac, Tanja Fauti, Christian Klein, Aintzane Zabaleta, Jens Hillengaß, Elisabetta Ada Cavalcanti‐Adam, Anthony D. Ho, Michael Hundemer, Jesús F. San Miguel, K. Strein, Pablo Umaña, Dirk Hose, Bruno Paiva, Minh Diem Vu - Cancer Cell 2017 cited by 312

  24. Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties

    Authors: Christian Klein, Alfred Lammens, Wolfgang Schäfer, Guy Georges, Manfred Schwaiger, Ekkehard Mössner, Karl‐Peter Hopfner, Pablo Umaña, Gerhard Niederfellner - mAbs 2013 cited by 386