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Gordon J. Freeman

Active 1985–2025

Also published as
GORDON J. FREEMAN
325
Papers
136,930
Citations
178
h-index
322
i10-index

Citations

Citations per year for Gordon J. Freeman1945: 1 citations1986: 1 citations1987: 5 citations1988: 6 citations1989: 25 citations1990: 36 citations1991: 38 citations1992: 90 citations1993: 169 citations1994: 307 citations1995: 357 citations1996: 311 citations1997: 237 citations1998: 224 citations1999: 271 citations2000: 229 citations2001: 279 citations2002: 340 citations2003: 460 citations2004: 510 citations2005: 583 citations2006: 556 citations2007: 767 citations2008: 853 citations2009: 926 citations2010: 961 citations2011: 896 citations2012: 927 citations2013: 946 citations2014: 935 citations2015: 1,547 citations2016: 1,947 citations2017: 2,203 citations2018: 2,349 citations2019: 5,920 citations2020: 6,638 citations2021: 6,855 citations2022: 5,389 citations2023: 4,212 citations2024: 6,050 citations2025: 3,001 citations2026: 125 citations1946–1985: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 15,255 citing papers, 29.2% of this breakdownChina: 9,798 citing papers, 18.8% of this breakdownGermany: 2,609 citing papers, 5% of this breakdownUnited Kingdom: 2,528 citing papers, 4.9% of this breakdownJapan: 2,001 citing papers, 3.8% of this breakdownFrance: 1,896 citing papers, 3.6% of this breakdownItaly: 1,836 citing papers, 3.5% of this breakdownCanada: 1,444 citing papers, 2.8% of this breakdownAustralia: 1,217 citing papers, 2.3% of this breakdownNetherlands: 1,127 citing papers, 2.2% of this breakdownSwitzerland: 1,063 citing papers, 2% of this breakdownSpain: 1,021 citing papers, 2% of this breakdown
0%29.2%Other 19.9%

Institutions

Fields

  • Medicine51.3%
  • Immunology and Microbiology26.7%
  • Biochemistry, Genetics and Molecular Biology18%
  • Engineering1.6%
  • Neuroscience1%
  • Materials Science0.3%
  • Other1.1%

Topics

  • Cancer Immunotherapy and Biomarkers11.7%
  • Immune Cell Function and Interaction8.7%
  • Immunotherapy and Immune Responses7.5%
  • CAR-T cell therapy research4.8%
  • T-cell and B-cell Immunology4.7%
  • Immune cells in cancer3.4%
  • Other59.2%

Coauthors

All papers

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  1. Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

    Authors: Peng Jiang, Shengqing Gu, Deng Pan, Jingxin Fu, Avinash Sahu, Xihao Hu, Ziyi Li, Nicole Traugh, Xia Bu, Bo Li, Jun Liu, Gordon J. Freeman, Myles Brown, Kai W. Wucherpfennig, X. Shirley Liu - Nature Medicine 2018 cited by 5,555

  2. PD-1 and Its Ligands in Tolerance and Immunity

    Authors: Mary Keir, Manish J. Butte, Gordon J. Freeman, Arlene H. Sharpe - Annual Review of Immunology 2008 cited by 5,342

  3. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

    Authors: Se Jin Im, Masao Hashimoto, Michael Y. Gerner, Junghwa Lee, Haydn Kissick, Matheus Carvalho Bürger, Qiang Shan, J. Scott Hale, Judong Lee, Tahseen H. Nasti, Arlene H. Sharpe, Gordon J. Freeman, Ronald N. Germain, Helder I. Nakaya, Hai‐Hui Xue, Rafi Ahmed - Nature 2016 cited by 2,144

  4. Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

    Authors: Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai, Karen Bourque, Tatyana Chernova, Hiroyuki Nishimura, Lori Fitz, Nelly Malenkovich, Taku Okazaki, Michael C. Byrne, Heidi F. Horton, Lynette A. Fouser, Laura Carter, Vincent Ling, Michael Bowman, Beatriz M. Carreno, Mary Collins, Clive R. Wood, Tasuku Honjo - The Journal of Experimental Medicine 2000 cited by 5,235

  5. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

    Authors: Nikolaos Patsoukis, Kankana Bardhan, Pranam Chatterjee, Duygu Sari, Bianling Liu, Lauren N. Bell, Edward D. Karoly, Gordon J. Freeman, Victoria Petkova, Pankaj Seth, Lequn Li, Vassiliki A. Boussiotis - Nature Communications 2015 cited by 1,162

  6. Fusobacterium nucleatumin colorectal carcinoma tissue and patient prognosis

    Authors: Kosuke Mima, Reiko Nishihara, Zhi Rong Qian, Yin Cao, Yasutaka Sukawa, Jonathan A. Nowak, Juhong Yang, Ruoxu Dou, Yohei Masugi, Mingyang Song, Aleksandar D. Kostic, Marios Giannakis, Susan Bullman, Danny A. Milner, Hideo Baba, Edward L. Giovannucci, Levi A. Garraway, Gordon J. Freeman, Glenn Dranoff, Wendy S. Garrett, Curtis Huttenhower, Matthew Meyerson, Jeffrey A. Meyerhardt, Andrew T. Chan, Charles S. Fuchs, Shuji Ogino - Gut 2015 cited by 1,074

  7. Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

    Authors: Shohei Koyama, Esra A. Akbay, Yvonne Y. Li, Grit S. Herter-Sprie, Kevin A. Buczkowski, William G. Richards, Leena Gandhi, Amanda J. Redig, Scott J. Rodig, Hajime Asahina, Robert E. Jones, Meghana Kulkarni, Mari Kuraguchi, Sangeetha Palakurthi, Peter E. Fecci, Bruce E. Johnson, Pasi A. Jänne, Jeffrey A. Engelman, Sidharta P. Gangadharan, Daniel B. Costa, Gordon J. Freeman, Raphael Bueno, F. Stephen Hodi, Glenn Dranoff, Kwok‐Kin Wong, Peter S. Hammerman - Nature Communications 2016 cited by 1,570

  8. Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

    Authors: David A. Braun, Yue Hou, Ziad Bakouny, Miriam Ficial, Miriam Sant’ Angelo, Juliet Forman, Petra Ross‐Macdonald, Ashton C. Berger, Opeyemi A. Jegede, Liudmilla Elagina, John A. Steinharter, Maxine Sun, Megan Wind‐Rotolo, Jean‐Christophe Pignon, Andrew D. Cherniack, Lee Lichtenstein, Donna Neuberg, Paul Catalano, Gordon J. Freeman, Arlene H. Sharpe, David F. McDermott, Eliezer M. Van Allen, Sabina Signoretti, Catherine J. Wu, Sachet A. Shukla, Toni K. Choueiri - Nature Medicine 2020 cited by 1,023

  9. Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

    Authors: Jinfang Zhang, Xia Bu, Haizhen Wang, Yasheng Zhu, Yan Geng, Naoe Taira Nihira, Yuyong Tan, Yanpeng Ci, Fei Wu, Xiangpeng Dai, Jianping Guo, Yuhan Huang, Caoqi Fan, Shancheng Ren, Yinghao Sun, Gordon J. Freeman, Piotr Siciński, Wenyi Wei - Nature 2017 cited by 1,049

  10. Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

    Authors: William Henry Hudson, Julia Gensheimer, Masao Hashimoto, Andreas Wieland, Rajesh M. Valanparambil, Peng Li, Jian‐Xin Lin, Bogumila T. Konieczny, Se Jin Im, Gordon J. Freeman, Warren J. Leonard, Haydn Kissick, Rafi Ahmed - Immunity 2019 cited by 676

  11. Restoring function in exhausted CD8 T cells during chronic viral infection

    Authors: Daniel L. Barber, E. John Wherry, David Masopust, Baogong Zhu, James P. Allison, Arlene H. Sharpe, Gordon J. Freeman, Rafi Ahmed - Nature 2005 cited by 3,998

  12. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

    Authors: Christopher Garris, Sean P. Arlauckas, Rainer H. Köhler, Marcel P. Trefny, Seth B. Garren, Cécile Piot, Camilla Engblom, Christina Pfirschke, Marie Siwicki, Jeremy Gungabeesoon, Gordon J. Freeman, Sarah Warren, SuFey Ong, Erica Browning, Chris Twitty, Robert H. Pierce, Mai H. Le, Alain P. Algazi, Adil Daud, Sara I. Pai, Alfred Zippelius, Ralph Weissleder, Mikaël J. Pittet - Immunity 2018 cited by 937

  13. Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

    Authors: Melvyn T. Chow, Aleksandra J. Ozga, Rachel L. Servis, Dennie T. Frederick, Jennifer A. Lo, David E. Fisher, Gordon J. Freeman, Genevieve M. Boland, Andrew D. Luster - Immunity 2019 cited by 710

  14. Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

    Authors: Ilaria Elia, Jared H. Rowe, Sheila Johnson, Shakchhi Joshi, Giulia Notarangelo, Kiran Kurmi, Sarah A. Weiss, Gordon J. Freeman, Arlene H. Sharpe, Marcia C. Haigis - Cell Metabolism 2022 cited by 341

  15. PD-L2 is a second ligand for PD-1 and inhibits T cell activation

    Authors: Yvette Latchman, Clive R. Wood, Tatyana Chernova, Divya Chaudhary, Madhuri Borde, Irene Chernova, Yoshiko Iwai, Andrew J. Long, Julia A. Brown, Raquel Nunes, Edward Greenfield, Karen Bourque, Vassiliki A. Boussiotis, Laura Carter, Beatriz M. Carreno, Nelly Malenkovich, Hiroyuki Nishimura, Taku Okazaki, Tasuku Honjo, Arlene H. Sharpe, Gordon J. Freeman - Nature Immunology 2001 cited by 2,948

  16. Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy

    Authors: Ying Zhang, Raj K. Kurupati, Ling Liu, Xiang Zhou, Gao Zhang, Abeer Hudaihed, Flavia Filisio, Wynetta Giles‐Davis, Xiaowei Xu, Giorgos C. Karakousis, Lynn M. Schuchter, Wei Xu, Ravi K. Amaravadi, Min Xiao, Norah Sadek, Clemens Krepler, Meenhard Herlyn, Gordon J. Freeman, Joshua D. Rabinowitz, Hildegund C.J. Ertl - Cancer Cell 2017 cited by 605

  17. PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

    Authors: Stephen M. Ansell, Alexander M. Lesokhin, Ivan Borrello, Ahmad Halwani, Emma C. Scott, Martin Gutierrez, Stephen J. Schuster, Michael Millenson, Deepika Cattry, Gordon J. Freeman, Scott J. Rodig, Bjoern Chapuy, Azra H. Ligon, Lili Zhu, Joseph F. Grosso, Su Young Kim, John M. Timmerman, Margaret A. Shipp, Philippe Armand - New England Journal of Medicine 2014 cited by 3,547

  18. The importance of exosomal PDL1 in tumour immune evasion

    Authors: Dhouha Daassi, Kathleen M. Mahoney, Gordon J. Freeman - Nature reviews. Immunology 2020 cited by 629

  19. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

    Authors: Matthew M. Gubin, Xiuli Zhang, Heiko Schuster, Étienne Caron, Jeffrey P. Ward, Takuro Noguchi, Yulia Ivanova, Jasreet Hundal, Cora D. Arthur, Willem-Jan Krebber, Gwenn E. Mulder, Mireille Toebes, Matthew D. Vesely, Samuel S.K. Lam, Alan J. Korman, James P. Allison, Gordon J. Freeman, Arlene H. Sharpe, Erika L. Pearce, Ton N. Schumacher, Ruedi Aebersold, Hans-Georg Rammensee, Cornelis J.M. Melief, Elaine R. Mardis, William E. Gillanders, Maxim N. Artyomov, Robert D. Schreiber - Nature 2014 cited by 2,006

  20. Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

    Authors: Alice O. Kamphorst, Andreas Wieland, Tahseen H. Nasti, Shu Yang, Ruan Zhang, Daniel L. Barber, Bogumila T. Konieczny, Candace Daugherty, Lydia Koenig, Yu Ke, Gabriel Sica, Arlene H. Sharpe, Gordon J. Freeman, Bruce R. Blazar, Laurence A. Turka, Taofeek K. Owonikoko, Rathi N. Pillai, Suresh S. Ramalingam, Koichi Araki, Rafi Ahmed - Science 2017 cited by 1,026

  21. PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

    Authors: Masao Hashimoto, Koichi Araki, Maria A. Cardenas, Peng Li, Rohit R. Jadhav, Haydn Kissick, William Henry Hudson, Donald J. McGuire, Rebecca C. Obeng, Andreas Wieland, Judong Lee, Daniel T. McManus, James Ross, Se Jin Im, Junghwa Lee, Jian‐Xin Lin, Bin Hu, Erin E. West, Christopher D. Scharer, Gordon J. Freeman, Arlene H. Sharpe, Suresh S. Ramalingam, Alex Pellerin, Volker Teichgräber, William J. Greenleaf, Christian Klein, Jörg J. Goronzy, Pablo Umaña, Warren J. Leonard, Kendall A. Smith, Rafi Ahmed - Nature 2022 cited by 321

  22. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

    Authors: Loise M. Francisco, Victor H. Salinas, Keturah Brown, Vijay K. Vanguri, Gordon J. Freeman, Vijay K. Kuchroo, Arlene H. Sharpe - The Journal of Experimental Medicine 2009 cited by 2,040

  23. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

    Authors: Laurent Monney, Catherine A. Sabatos, Jason L. Gaglia, Akemi Ryu, Hanspeter Waldner, Tatyana Chernova, Stephen Manning, Edward Greenfield, Anthony J. Coyle, Raymond A. Sobel, Gordon J. Freeman, Vijay K. Kuchroo - Nature 2002 cited by 1,635

  24. LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

    Authors: Wanqiang Sheng, Martin W. LaFleur, Thao H. Nguyen, Sujun Chen, Ankur Chakravarthy, Jake R. Conway, Ying Li, Hao Chen, Henry Yang, Pang‐Hung Hsu, Eliezer M. Van Allen, Gordon J. Freeman, Daniel D. De Carvalho, Housheng Hansen He, Arlene H. Sharpe, Yang Shi - Cell 2018 cited by 692