David C. Chan
Active 1991–2025
- 98
- Papers
- 40,267
- Citations
- 78
- h-index
- 96
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Biochemistry, Genetics and Molecular Biology53.9%
- Medicine31.5%
- Immunology and Microbiology6.4%
- Neuroscience3.9%
- Agricultural and Biological Sciences0.8%
- Environmental Science0.7%
- Other2.8%
Topics
- Mitochondrial Function and Pathology15.6%
- Autophagy in Disease and Therapy5.8%
- ATP Synthase and ATPases Research5.5%
- Metabolism and Genetic Disorders3.3%
- Adipose Tissue and Metabolism2.9%
- Endoplasmic Reticulum Stress and Disease1.6%
- Other65.3%
Coauthors
- Hsiuchen Chen19
- Prashant Mishra9
- J. Michael McCaffery8
- Grigor Varuzhanyan6
- Shuxia Meng6
- Zhiyin Song6
- Philip Leder5
- Scott A. Detmer5
- Valério Carelli5
- Anh H. Pham4
- Michael J. Sweredoski4
- Peter S. Kim4
- Raymond Liu4
- Anne Chomyn3
- Chun-Shik Shin3
- Hiromi Sesaki3
- Jens T. Kaiser3
- Mark S. Ladinsky3
- Oliver C. Losón3
- Rebecca Rojansky3
- Shun‐ichi Yamashita3
- Tomotake Kanki3
- Alessandra Maresca2
- Annie Moradian2
All papers
- Mitochondrial Dynamics and Its Involvement in Disease
Authors: David C. Chan - Annual Review of Pathology Mechanisms of Disease 2019 cited by 1,400
- Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Authors: Hsiuchen Chen, Scott A. Detmer, Andrew J. Ewald, Erik E. Griffin, Scott E. Fraser, David C. Chan - The Journal of Cell Biology 2003 cited by 2,557
- AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
Authors: Erin Quan Toyama, Sébastien Herzig, Julien Courchet, Tommy L. Lewis, Oliver C. Losón, Kristina Hellberg, Nathan P. Young, Hsiuchen Chen, Franck Polleux, David C. Chan, Reuben J. Shaw - Science 2016 cited by 1,083
- Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
Authors: Oliver C. Losón, Zhiyin Song, Hsiuchen Chen, David C. Chan - Molecular Biology of the Cell 2013 cited by 1,209
- Metabolic regulation of mitochondrial dynamics
Authors: Prashant Mishra, David C. Chan - The Journal of Cell Biology 2016 cited by 1,108
- Solving neurodegeneration: common mechanisms and strategies for new treatments
Authors: Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl L. Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, Marta Soler, John G. Flanagan, Preeti Subramanian, Sharyn L. Rossi, Thomas M. Brunner, Diane E. Bovenkamp, David J. Calkins - Molecular Neurodegeneration 2022 cited by 307
- Mitochondrial dynamics and inheritance during cell division, development and disease
Authors: Prashant Mishra, David C. Chan - Nature Reviews Molecular Cell Biology 2014 cited by 1,033
- Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations
Authors: Hsiuchen Chen, Marc Vermulst, Yun E. Wang, Anne Chomyn, Tomas A. Prolla, J. Michael McCaffery, David C. Chan - Cell 2010 cited by 1,223
- Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
Authors: David C. Chan - Annual Review of Genetics 2011 cited by 1,179
- Mitochondria: Dynamic Organelles in Disease, Aging, and Development
Authors: David C. Chan - Cell 2006 cited by 1,995
- Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction
Authors: Hsiuchen Chen, Anne Chomyn, David C. Chan - Journal of Biological Chemistry 2005 cited by 1,336
- Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
Authors: Hui Chen, David C. Chan - Human Molecular Genetics 2009 cited by 1,455
- Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion
Authors: Zhiyin Song, Mariam Ghochani, J. Michael McCaffery, Terrence Frey, David C. Chan - Molecular Biology of the Cell 2009 cited by 594
- Functions and dysfunctions of mitochondrial dynamics
Authors: Scott A. Detmer, David C. Chan - Nature Reviews Molecular Cell Biology 2007 cited by 1,358
- SLP‐2 is required for stress‐induced mitochondrial hyperfusion
Authors: Daniel Tondera, Stéphanie Grandemange, Alexis A. Jourdain, Mariusz Karbowski, Yves Mattenberger, Sébastien Herzig, Sandrine Da Cruz, Pascaline Clerc, Ines Raschke, Carsten Merkwirth, Sarah Ehses, Frank Krause, David C. Chan, Christiane Alexander, Christoph Bauer, Richard J. Youle, Thomas Langer, Jean‐Claude Martinou - The EMBO Journal 2009 cited by 766
- Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
Authors: Nickie C. Chan, Anna M. Salazar, Anh H. Pham, Michael J. Sweredoski, Natalie J. Kolawa, R. L. Graham, Sonja Hess, David C. Chan - Human Molecular Genetics 2011 cited by 972
- Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation
Authors: Prashant Mishra, Valério Carelli, Giovanni Manfredi, David C. Chan - Cell Metabolism 2014 cited by 474
- Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells
Authors: Hsiuchen Chen, David C. Chan - Cell Metabolism 2017 cited by 462
- Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
Authors: Kook Hwan Kim, Yeon Taek Jeong, Hyunhee Oh, Seong‐Hun Kim, Jae Min Cho, Yona Kim, Su Sung Kim, Do‐Hoon Kim, Kyu Yeon Hur, Hyoung Kyu Kim, Tae-Hee Ko, Jin Han, Hong Lim Kim, Jin Kim, Sung Hoon Back, Masaaki Komatsu, Hsiuchen Chen, David C. Chan, Morichika Konishi, Nobuyuki Itoh, Cheol Soo Choi, Myung‐Shik Lee - Nature Medicine 2012 cited by 768
- The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
Authors: Chun-Shik Shin, Prashant Mishra, Jeramie D. Watrous, Valério Carelli, Marilena D’Aurelio, Mohit Jain, David C. Chan - Nature Communications 2017 cited by 301
- SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress
Authors: Sadhana Samant, Hannah J. Zhang, Zhigang Hong, Vinodkumar B. Pillai, Nagalingam R. Sundaresan, Donald J. Wolfgeher, Stephen L. Archer, David C. Chan, Mahesh P. Gupta - Molecular and Cellular Biology 2013 cited by 428
- Structural Basis of Mitochondrial Tethering by Mitofusin Complexes
Authors: Takumi Koshiba, Scott A. Detmer, Jens T. Kaiser, Hsiuchen Chen, J. Michael McCaffery, David C. Chan - Science 2004 cited by 893
- OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L
Authors: Zhiyin Song, Hsiuchen Chen, Maja Fiket, Christiane Alexander, David C. Chan - The Journal of Cell Biology 2007 cited by 810
- Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1
Authors: Rebecca Rojansky, Moon-Yong Cha, David C. Chan - eLife 2016 cited by 333
