David S. Park
Active 1953–2025
- Also published as
- David S Park
- 111
- Papers
- 21,753
- Citations
- 87
- h-index
- 110
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine43.6%
- Biochemistry, Genetics and Molecular Biology37.5%
- Neuroscience9.7%
- Computer Science1.8%
- Immunology and Microbiology1.5%
- Engineering1%
- Other4.9%
Topics
- Mitochondrial Function and Pathology7.4%
- Parkinson's Disease Mechanisms and Treatments7.1%
- Autophagy in Disease and Therapy5.9%
- Alzheimer's disease research and treatments3.2%
- Cell death mechanisms and regulation2.7%
- Neuroinflammation and Neurodegeneration Mechanisms2.3%
- Other71.4%
Coauthors
- Ruth S. Slack56
- Steve Callaghan16
- Jason G. MacLaurin15
- Lloyd A. Greene11
- Sean P. Cregan10
- Steven Callaghan9
- Hossein Aleyasin8
- Leonidas Stefanis8
- Patrice D. Smith8
- Tak W. Mak8
- Dianbo Qu7
- Erick J. Morris7
- Hymie Anisman7
- Jacqueline L. Vanderluit7
- Matthew Mount7
- Michael J. O’Hare7
- Shawn Hayley7
- Alvin Joselin6
- Diane C. Lagace6
- Elizabeth Keramaris6
- Heidi M. McBride6
- Maxime W.C. Rousseaux6
- Raymond H. Kim6
- Stephen J. Crocker6
All papers
- Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program
Authors: Mireille Khacho, Alysen Clark, Devon S. Svoboda, Joëlle Azzi, Jason G. MacLaurin, Cynthia Meghaizel, Hiromi Sesaki, Diane C. Lagace, Marc Germain, Mary‐Ellen Harper, David S. Park, Ruth S. Slack - Cell stem cell 2016 cited by 687
- Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
Authors: Andrew W Greene, Karl Grenier, Miguel Aguileta, Stephanie Muise, Rasoul Farazifard, M. Emdadul Haque, Heidi M. McBride, David S Park, Edward A. Fon - EMBO Reports 2012 cited by 702
- β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
Authors: Shuchi Mittal, Kjetil Bjørnevik, Doo Soon Im, Adrian Flierl, Xianjun Dong, Joseph J. Locascio, Kristine M. Abo, Elizabeth Long, Ming Jin, Bing Xu, Yang K. Xiang, Jean‐Christophe Rochet, Anders Engeland, Patrizia Rizzu, Peter Heutink, Tim Bartels, Dennis J. Selkoe, Barbara J. Caldarone, Marcie A. Glicksman, Vikram Khurana, Birgitt Schüle, David S. Park, Trond Riise, Clemens R. Scherzer - Science 2017 cited by 437
- OPA1‐dependent cristae modulation is essential for cellular adaptation to metabolic demand
Authors: David A. Patten, Jacob Wong, Mireille Khacho, Vincent Soubannier, Ryan J. Mailloux, Karine Pilon‐Larose, Jason G. MacLaurin, David S Park, Heidi M. McBride, Laura Trinkle‐Mulcahy, Mary‐Ellen Harper, Marc Germain, Ruth S. Slack - The EMBO Journal 2014 cited by 403
- Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission
Authors: Ruben K. Dagda, Salvatore J. Cherra, Scott Kulich, Anurag Tandon, David S. Park, Charleen T. Chu - Journal of Biological Chemistry 2009 cited by 955
- Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts
Authors: Aruna Kode, John S. Manavalan, Ioanna Mosialou, Govind Bhagat, Chozha Vendan Rathinam, Na Luo, Hossein Khiabanian, Albert Lee, Vundavalli V. Murty, Richard A. Friedman, Andrea M. Brum, David S. Park, Naomi Galili, Siddhartha Mukherjee, Julie Teruya‐Feldstein, Azra Raza, Raúl Rabadán, Ellin Berman, Stavroula Kousteni - Nature 2014 cited by 516
- Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis
Authors: Mireille Khacho, Alysen Clark, Devon S. Svoboda, Jason G. MacLaurin, Diane C. Lagace, David S. Park, Ruth S. Slack - Human Molecular Genetics 2017 cited by 189
- Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
Authors: Raymond H. Kim, Patrice D. Smith, Hossein Aleyasin, Shawn Hayley, Matthew Mount, Scott Pownall, Andrew Wakeham, Annick You-Ten, Suneil K. Kalia, Patrick Horne, David Westaway, Andrés M. Lozano, Hymie Anisman, David S. Park, Tak W. Mak - National Academy of Sciences, Proceedings of the National Academy of Sciences 2005 cited by 707
- Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
Authors: Isabella Irrcher, Hossein Aleyasin, Erin L. Seifert, Sarah J. Hewitt, Shivani Chhabra, Melissa Phillips, A. Kathrin Lutz, Maxime W.C. Rousseaux, Lisa Bevilacqua, Arezu Jahani‐Asl, Steve Callaghan, Jason G. MacLaurin, Konstanze F. Winklhofer, Patrizia Rizzu, Peter Rippstein, Raymond H. Kim, C.X. Chen, Edward A. Fon, Ruth S. Slack, Mary‐Ellen Harper, Heidi M. McBride, Tak W. Mak, David S. Park - Human Molecular Genetics 2010 cited by 382
- Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
Authors: Niamh M. C. Connolly, Pierre Theurey, Vera Ádám‐Vizi, Nicolás G. Bazán, Paolo Bernardi, Juan P. Bolaños, Carsten Culmsee, Valina L. Dawson, Mohanish Deshmukh, Michael R. Duchen, Heiko Düßmann, Gary Fiskum, Marı́a F. Galindo, Giles E. Hardingham, J. Marie Hardwick, Mika B. Jekabsons, Elizabeth A. Jonas, Joaquı́n Jordán, Stuart A. Lipton, Giovanni Manfredi, Mark P. Mattson, BethAnn McLaughlin, Axel Methner, Anne N. Murphy, Michael P. Murphy, David G. Nicholls, Brian M. Polster, Tullio Pozzan, Rosario Rizzuto, Jorgina Satrústegui, Ruth S. Slack, Raymond A. Swanson, Russell H. Swerdlow, Yvonne Will, Zheng Ying, Alvin Joselin, Anna Gioran, Catarina Moreira Pinho, Orla Watters, Manuela Salvucci, Irene Llorente‐Folch, David S. Park, Daniele Bano, Maria Ankarcrona, Paola Pizzo, Jochen H.M. Prehn - Cell Death and Differentiation 2017 cited by 208
- Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
Authors: Lennart N. Bouman, Anita Schlierf, A. Kathrin Lutz, Jixiu Shan, Alexandra Deinlein, Jürgen Kast, Zohreh Galehdar, V Palmisano, N Patenge, Daniela Berg, Thomas Gasser, René Augustin, Dietrich Trümbach, Isabella Irrcher, David S. Park, Wolfgang Wurst, M S Kilberg, Jörg Tatzelt, Konstanze F. Winklhofer - Cell Death and Differentiation 2010 cited by 343
- Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4–CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA
Authors: Zohreh Galehdar, Patrick Swan, Benjamin J. Fuerth, Steven Callaghan, David S. Park, Sean P. Cregan - Journal of Neuroscience 2010 cited by 352
- Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival
Authors: Mireille Khacho, Michelle Tarabay, David A. Patten, Pamela Khacho, Jason G. MacLaurin, Jennifer Guadagno, Richard Bergeron, Sean P. Cregan, Mary‐Ellen Harper, David S. Park, Ruth S. Slack - Nature Communications 2014 cited by 193
- Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
Authors: Mansoureh Hakimi, Thirumahal Selvanantham, Erika Swinton, Ruth Padmore, Youren Tong, Ghassan Kabbach, Kateřina Venderová, Stephen E. Girardin, Dennis E. Bulman, Clemens R. Scherzer, Matthew J. LaVoie, Denis Gris, David S. Park, Jonathan B. Angel, Jie Shen, Dana J. Philpott, Michael G. Schlossmacher - Journal of Neural Transmission 2011 cited by 292
- Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit
Authors: Jing Yang, Zhuhao Wu, Nicolas Renier, David Simon, Kunihiro Uryu, David S. Park, Peter A. Greer, Cathy Tournier, Roger J. Davis, Marc Tessier‐Lavigne - Cell 2015 cited by 307
- Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites
Authors: Jacqueline M. Tokarew, Daniel N. El-Kodsi, Nathalie A. Lengacher, Travis K. Fehr, Angela Nguyen, Bojan Shutinoski, Brian O’Nuallain, Ming Jin, Jasmine M. Khan, Andy Cheuk‐Him Ng, Juan Li, Qiubo Jiang, Mei Zhang, Liqun Wang, Rajib Sengupta, Kathryn R. Barber, An Tran, Doo Soon Im, Steve Callaghan, David S. Park, Stéphanie Zandee, Xiajun Dong, Clemens R. Scherzer, Alexandre Prat, Eve C. Tsai, Masashi Takanashi, Nobutaka Hattori, Jennifer A. Chan, Luigi Zecca, Andrew B. West, Arne Holmgren, Lawrence G. Puente, Gary S. Shaw, Gergely Tóth, John Woulfe, Peggy Taylor, Julianna J. Tomlinson, Michael G. Schlossmacher - Acta Neuropathologica 2021 cited by 61
- Involvement of Interferon-γ in Microglial-Mediated Loss of Dopaminergic Neurons
Authors: Matthew Mount, Arman Lira, David A. Grimes, Patrice D. Smith, Sylvie Faucher, Ruth S. Slack, Hymie Anisman, Shawn Hayley, David S. Park - Journal of Neuroscience 2007 cited by 303
- Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner
Authors: Bojan Shutinoski, Mansoureh Hakimi, Irene E. Harmsen, Michaela Lunn, Juliana Dutra Barbosa da Rocha, Nathalie A. Lengacher, Yi Zhou, Jasmine M. Khan, Angela Nguyen, Quinton Hake-Volling, Daniel N. El-Kodsi, Juan Li, Azadeh Alikashani, Claudine Beauchamp, Jay Majithia, Kevin M. Coombs, Derya R. Shimshek, Paul C. Marcogliese, David S. Park, John D. Rioux, Dana J. Philpott, John Woulfe, Shawn Hayley, Subash Sad, Julianna J. Tomlinson, Earl G. Brown, Michael G. Schlossmacher - Science Translational Medicine 2019 cited by 102
- Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy
Authors: Maria Xilouri, Tereza Vogiatzi, Kostas Vekrellis, David S. Park, Leonidas Stefanis - PLoS ONE 2009 cited by 347
- Programmed Cell Death in Parkinson's Disease
Authors: Kateřina Venderová, David S. Park - Cold Spring Harbor Perspectives in Medicine 2012 cited by 244
- Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease
Authors: Kwang S. Kim, Paul C. Marcogliese, Jungwoo Yang, Steve Callaghan, Virgínia Maria Ferreira Resende, Elizabeth Abdel-Messih, Connie Marras, Naomi P. Visanji, Jana Huang, Michael G. Schlossmacher, Laura Trinkle‐Mulcahy, Ruth S. Slack, Anthony E. Lang, Canadian Lrrk2 in Inflammation Team (CLINT), David S. Park, Earl G. Brown, Derrick Gibbings, Shawn Hayley, David S. Park, Dana C. Philpott, John D. Rioux, Michael G. Schlossmacher, Erwin Schurr - National Academy of Sciences, Proceedings of the National Academy of Sciences 2018 cited by 118
- PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
Authors: En Huang, Dianbo Qu, Tianwen Huang, Nicoletta Rizzi, Wassamon Boonying, Dorothy Krolak, Paolo Ciana, John Woulfe, Christine Klein, Ruth S. Slack, Daniel Figeys, David S. Park - Nature Communications 2017 cited by 112
- Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort
Authors: Kelly M. Sunderland, Derek Beaton, Stephen R. Arnott, Peter Kleinstiver, Donna Kwan, Jane M. Lawrence‐Dewar, Joel Ramirez, Brian Tan, Robert Bartha, Sandra E. Black, Michael Borrie, Donald C. Brien, Leanne K. Casaubon, Brian C. Coe, Benjamin Cornish, Allison A. Dilliott, Dar Dowlatshahi, Elizabeth Finger, Corinne E. Fischer, Andrew Frank, Julia Fraser, Morris Freedman, Barry Greenberg, David A. Grimes, Ayman Hassan, Wendy Hatch, Robert A. Hegele, Christopher Hudson, Mandar Jog, Sanjeev Kumar, Anthony E. Lang, Brian Levine, Wendy Lou, Jennifer Mandzia, Connie Marras, William E. McIlroy, Manuel Montero‐Odasso, David G. Munoz, Douglas P. Munoz, J. B. Orange, David S. Park, Stephen Pasternak, Frederico Pieruccini‐Faria, Tarek K. Rajji, Angela Roberts, John F. Robinson, Ekaterina Rogaeva, Demetrios J. Sahlas, Gustavo Saposnik, Christopher J.M. Scott, Dallas Seitz, Christen Shoesmith, Thomas Steeves, Michael J. Strong, Stephen C. Strother, Richard H. Swartz, Sean Symons, David F. Tang‐Wai, Maria Carmela Tartaglia, Angela K. Troyer, John Turnbull, Lorne Zinman, Paula McLaughlin, Mario Masellis, Malcolm A. Binns, the ONDRI Investigators - Alzheimer s & Dementia 2022 cited by 31
- Cyclin-dependent kinases as a therapeutic target for stroke
Authors: Hitoshi Osuga, Sachiko Osuga, Fuhu Wang, Raouf Fetni, Matthew J. Hogan, Ruth S. Slack, Antoine M. Hakim, Joh‐E Ikeda, David S. Park - National Academy of Sciences, Proceedings of the National Academy of Sciences 2000 cited by 281
