David Westaway
Active 1981–2025
- 90
- Papers
- 23,268
- Citations
- 74
- h-index
- 89
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine55.1%
- Biochemistry, Genetics and Molecular Biology32.3%
- Neuroscience7.1%
- Nursing2.1%
- Immunology and Microbiology0.6%
- Agricultural and Biological Sciences0.5%
- Other2.3%
Topics
- Alzheimer's disease research and treatments17.6%
- Prion Diseases and Protein Misfolding8.5%
- Neurological diseases and metabolism4.6%
- Trace Elements in Health4.5%
- Cholinesterase and Neurodegenerative Diseases4.5%
- Computational Drug Discovery Methods3.8%
- Other56.5%
Coauthors
- Peter St George‐Hyslop23
- Stanley B. Prusiner22
- George A. Carlson18
- Paul E. Fraser15
- M. Azhar Chishti11
- Patrick Horne9
- Howard T.J. Mount8
- Jing Yang8
- Christopher Janus7
- Stephen J. DeArmond7
- Fusheng Chen6
- Gerold Schmitt‐Ulms6
- JoAnne McLaurin6
- Joel C. Watts6
- Paul Fraser6
- Paul M. Mathews6
- Peter Mastrangelo6
- Ralph A. Nixon6
- Sang‐Gyun Kang6
- Amie L. Phinney5
- Darlene Groth5
- Kefeng Qin5
- Marilyn Torchia5
- Robert Strome5
All papers
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Authors: Ju‐Hyun Lee, Wai Haung Yu, Asok Kumar, Sooyeon Lee, Panaiyur S. Mohan, Corrinne M. Peterhoff, Devin M. Wolfe, Marta Martínez‐Vicente, Ashish C. Massey, Guy Sovak, Yasuo Uchiyama, David Westaway, Ana María Cuervo, Ralph A. Nixon - Cell 2010 cited by 1,216
- Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
Authors: M. Azhar Chishti, Dun-Shen Yang, Christopher Janus, Amie L. Phinney, Patrick Horne, Jacqueline Pearson, Robert Strome, Noah B. Zuker, James Loukides, Janet French, Sherry Turner, Gianluca Lozza, Mariagrazia Grilli, Suzanne Kunicki, Céline Morissette, Julie Paquette, Francine Gervais, Catherine Bergeron, Paul E. Fraser, George A. Carlson, Peter St George‐Hyslop, David Westaway - Journal of Biological Chemistry 2001 cited by 954
- Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
Authors: Raymond H. Kim, Patrice D. Smith, Hossein Aleyasin, Shawn Hayley, Matthew Mount, Scott Pownall, Andrew Wakeham, Annick You-Ten, Suneil K. Kalia, Patrick Horne, David Westaway, Andrés M. Lozano, Hymie Anisman, David S. Park, Tak W. Mak - National Academy of Sciences, Proceedings of the National Academy of Sciences 2005 cited by 707
- Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
Authors: Martin Citron, David Westaway, Weiming Xia, George A. Carlson, Thekla S. Diehl, Georges Lévesque, Kelly Johnson‐Wood, Michael Lee, Peter Seubert, Angela Davis, Dora Kholodenko, Ruth Motter, Robin Sherrington, Billie J. Perry, Hong Yao, Robert Strome, Ivan Lieberburg, Johanna M. Rommens, Soyeon Kim, Dale Schenk, Paul Fraser, Peter St George‐Hyslop, Dennis J. Selkoe - Nature Medicine 1997 cited by 1,267
- Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Authors: Christopher Janus, Jacqueline Pearson, JoAnne McLaurin, Paul M. Mathews, Ying Jiang, Stephen D. Schmidt, M. Azhar Chishti, Patrick Horne, Donna Heslin, Janet French, Howard T.J. Mount, Ralph A. Nixon, Marc Mercken, Catherine Bergeron, Paul E. Fraser, Peter St George‐Hyslop, David Westaway - Nature 2000 cited by 1,434
- Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
Authors: Dun-Sheng Yang, Philip Stavrides, Panaiyur S. Mohan, Susmita Kaushik, Asok Kumar, Masuo Ohno, Stephen D. Schmidt, Daniel W. Wesson, Urmi Bandyopadhyay, Ying Jiang, Monika Pawlik, Corrinne M. Peterhoff, Austin J. Yang, Donald A. Wilson, Peter St George‐Hyslop, David Westaway, Paul M. Mathews, Efrat Levy, Ana María Cuervo, Ralph A. Nixon - Brain 2010 cited by 429
- Oleic Acid Ameliorates Amyloidosis in Cellular and Mouse Models of Alzheimer's Disease
Authors: Zareen Amtul, David Westaway, David F. Cechetto, Richard Rozmahel - Brain Pathology 2010 cited by 138
- The cellular prion protein binds copper in vivo
Authors: David R. Brown, Kefeng Qin, Jochen Herms, Axel Madlung, Jean Manson, Robert Strome, Paul E. Fraser, Theo P.A. Kruck, Alex von Bohlen, Walter Schulz‐Schaeffer, Armin Giese, David Westaway, Hans A. Kretzschmar - Nature 1997 cited by 1,270
- Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathology
Authors: Shinjiro Fukami, Kaori Watanabe, Nobuhisa Iwata, Jo Haraoka, Bao Lu, Norma P. Gerard, Craig Gérard, Paul Fraser, David Westaway, Peter St George‐Hyslop, Takaomi C. Saido - Neuroscience Research 2002 cited by 155
- Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity
Authors: Wenbin Fu, Diya Shi, David Westaway, Jack H. Jhamandas - Journal of Biological Chemistry 2015 cited by 89
- Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease
Authors: Chae Kim, Tracy Haldiman, Sang‐Gyun Kang, Lenka Hromádková, Zhuang Zhuang Han, Wei Chen, Frances Lissemore, Alan J. Lerner, Rohan de Silva, Mark L. Cohen, David Westaway, Jiri Safar - Science Translational Medicine 2022 cited by 60
- Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques
Authors: Michael Scott, Dallas Foster, C. Mirenda, Dan Serban, Frank Coufal, Monika Wälchli, Marilyn Torchia, Darlene Groth, George A. Carlson, Stephen J. DeArmond, David Westaway, Stanley B. Prusiner - Cell 1989 cited by 698
- A cellular gene encodes scrapie PrP 27-30 protein
Authors: Bruno Oesch, David Westaway, Monika Wälchli, Michael P. McKinley, Stephen B. H. Kent, Ruedi Aebersold, Ronald A. Barry, Paul Tempst, David B. Teplow, Leroy Hood, Stanley B. Prusiner, Charles Weissmann - Cell 1985 cited by 1,504
- Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
Authors: Stanley B. Prusiner, Michael Scott, Dallas Foster, Keh‐Ming Pan, Darlene Groth, C. Mirenda, Marilyn Torchia, Shu-Lian Yang, Dan Serban, George A. Carlson, Peter C. Hoppe, David Westaway, Stephen J. DeArmond - Cell 1990 cited by 870
- Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
Authors: Konrad Basler, Bruno Oesch, Michael Scott, David Westaway, Monika Wälchli, Darlene Groth, Michael P. McKinley, Stanley B. Prusiner, Charles Weissmann - Cell 1986 cited by 832
- Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model
Authors: JoAnne McLaurin, Meredith E. Kierstead, Mary E. Brown, Cheryl A. Hawkes, Mark H. L. Lambermon, Amie L. Phinney, Audrey A. Darabie, Julian E. Cousins, J.E. French, Melissa F Lan, Fusheng Chen, Sydney Sek Ning Wong, Howard T.J. Mount, Paul E. Fraser, David Westaway, Peter St George‐Hyslop - Nature Medicine 2006 cited by 364
- Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.
Authors: Satyabrata Kar, Stephen P.M. Slowikowski, David Westaway, Howard T.J. Mount - 2004 cited by 349
- TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity
Authors: Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt‐Ulms, Toshitaka Kawarai, Christopher Böhm, Taiichi Katayama, Yongjun Gu, Nobuo Sanjo, Michael J. Glista, Ekaterina Rogaeva, Yosuke Wakutani, Raphaëlle Pardossi‐Piquard, Xueying Ruan, Anurag Tandon, Frédéric Checler, Philippe Marambaud, Kirk C. Hansen, David Westaway, Peter St George‐Hyslop, Paul Fraser - Nature 2006 cited by 297
- VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival
Authors: Piotr Religa, Renhai Cao, Dorota Religa, Yuan Xue, Nenad Bogdanović, David Westaway, Hugo H. Marti, Bengt Winblad, Yihai Cao - Scientific Reports 2013 cited by 130
- Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis
Authors: Mahua Maulik, David Westaway, Jack H. Jhamandas, Satyabrata Kar - Molecular Neurobiology 2012 cited by 117
- Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease
Authors: Zareen Amtul, L. Wang, David Westaway, Richard Rozmahel - Neuroscience 2010 cited by 102
- RNA Therapeutics Directed to the Non Coding Regions of APP mRNA, In Vivo Anti-Amyloid Efficacy of Paroxetine, Erythromycin, and N-acetyl cysteine
Authors: Stephanie C. Tucker, Michelle Ahl, Hyun-Hee Cho, Sanghamitra Bandyopadhyay, Gregory D. Cuny, Ashley I. Bush, Lee E. Goldstein, David Westaway, Xudong Huang, Jack T. Rogers - Current Alzheimer Research 2006 cited by 61
- Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
Authors: Wim Annaert, Lyne Lévesque, Katleen Craessaerts, Inge Dierinck, Greet Snellings, David Westaway, Peter St George‐Hyslop, Barbara Cordell, Paul Fraser, Bart De Strooper - The Journal of Cell Biology 1999 cited by 312
- Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
Authors: John Steele, M. Lenard Lachenmayer, Shang Ju, Aryeh Stock, J. Liken, S.H. Kim, Luz Delgado, Iván E. Alfaro, Sebastián Bernales, Giuseppe Verdile, Prashant Bharadwaj, Veer Bala Gupta, Renae K. Barr, A. Friss, Georgia Dolios, Ryan Wang, Dagmar Ringe, Paul E. Fraser, David Westaway, Peter St George‐Hyslop, Piroska E. Szabó, Norman Relkin, Joseph D. Buxbaum, Charles Glabe, Andrew A. Protter, Ralph N. Martins, Michelle E. Ehrlich, Gregory A. Petsko, Zhenyu Yue, Sam Gandy - Molecular Psychiatry 2012 cited by 112
