Fred S. Apple
Active 1985–2025
- Also published as
- Fred S Apple
- 145
- Papers
- 33,597
- Citations
- 92
- h-index
- 143
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine83.7%
- Biochemistry, Genetics and Molecular Biology8.3%
- Engineering2.2%
- Immunology and Microbiology1.5%
- Health Professions0.7%
- Neuroscience0.5%
- Other3.1%
Topics
- Acute Myocardial Infarction Research11.1%
- Cardiac Imaging and Diagnostics7%
- Coronary Interventions and Diagnostics4.1%
- Heart Failure Treatment and Management2.8%
- Cardiac, Anesthesia and Surgical Outcomes2.6%
- Cardiovascular Function and Risk Factors2.3%
- Other70.1%
Coauthors
- Allan S. Jaffe32
- Alan H.B. Wu24
- Nicholas L. Mills24
- Paul Collinson24
- Robert H. Christenson24
- Yader Sandoval24
- MaryAnn M Murakami19
- Andrew R. Chapman17
- Atul Anand16
- Kuan Ken Lee16
- Stephen W. Smith16
- Karen Schulz15
- Amy V. Ferry14
- Fiona E. Strachan14
- Peter A. Kavsak13
- Anoop Shah12
- Martin Than12
- Christopher Tuck11
- David E. Newby11
- Louise Cullen11
- Alasdair Gray10
- Amy K. Saenger10
- Anda Bularga10
- Jordi Ordóñez‐Llanos10
All papers
- Fourth universal definition of myocardial infarction (2018)
Authors: Kristian Thygesen, Joseph S. Alpert, Allan S. Jaffe, Bernard Chaitman, Jeroen J. Bax, David A. Morrow, Harvey D. White, ESC Scientific Document Group, Kristian Thygesen, Joseph S Alpert, Allan S Jaffe, Bernard R Chaitman, Jeroen J Bax, David A Morrow, Harvey D White, Hans Mickley, Filippo Crea, Frans Van de Werf, Chiara Bucciarelli-Ducci, Hugo A Katus, Fausto J Pinto, Elliott M Antman, Christian W Hamm, Raffaele De Caterina, James L Januzzi, Fred S Apple, Maria Angeles Alonso Garcia, S Richard Underwood, John M Canty, Alexander R Lyon, P J Devereaux, Jose Luis Zamorano, Bertil Lindahl, William S Weintraub, L Kristin Newby, Renu Virmani, Pascal Vranckx, Don Cutlip, Raymond J Gibbons, Sidney C Smith, Dan Atar, Russell V Luepker, Rose Marie Robertson, Robert O Bonow, P Gabriel Steg, Patrick T O’Gara, Keith A A Fox, David Hasdai, Victor Aboyans, Stephan Achenbach, Stefan Agewall, Thomas Alexander, Alvaro Avezum, Emanuele Barbato, Jean-Pierre Bassand, Eric Bates, John A Bittl, Güenter Breithardt, Héctor Bueno, Raffaele Bugiardini, Mauricio G Cohen, George Dangas, James A de Lemos, Victoria Delgado, Gerasimos Filippatos, Edward Fry, Christopher B Granger, Sigrun Halvorsen, Mark A Hlatky, Borja Ibanez, Stefan James, Adnan Kastrati, Christophe Leclercq, Kenneth W Mahaffey, Laxmi Mehta, Christian Müller, Carlo Patrono, Massimo Francesco Piepoli, Daniel Piñeiro, Marco Roffi, Andrea Rubboli, Samin Sharma, Iain A Simpson, Michael Tendera, Marco Valgimigli, Allard C van der Wal, Stephan Windecker, Mohamed Chettibi, Hamlet Hayrapetyan, Franz Xaver Roithinger, Farid Aliyev, Volha Sujayeva, Marc J Claeys, Elnur Smajić, Petr Kala, Kasper Karmak Iversen, Ehab El Hefny, Toomas Marandi, Pekka Porela, Slobodan Antov and 29 more - European Heart Journal 2018 cited by 5,819
- Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1
Authors: Heiko Johnen, Shu Lin, Támara Kuffner, David A. Brown, Vicky Wang-Wei Tsai, Asne R. Bauskin, Liyun Wu, Greg J. Pankhurst, Lele Jiang, Simon Junankar, Mark Hunter, W. Douglas Fairlie, Nicola J. Lee, Ronaldo F. Enriquez, Paul A. Baldock, Eva Corey, Fred S. Apple, MaryAnn M Murakami, En-Ju D. Lin, Chuansong Wang, Matthew J. During, Amanda Sainsbury, Herbert Herzog, Samuel N. Breit - Nature Medicine 2007 cited by 597
- Third Universal Definition of Myocardial Infarction
Authors: Kristian Thygesen, Joseph S. Alpert, Allan S. Jaffe, Maarten L. Simoons, Bernard Chaitman, Harvey D. White, Kristian Thygesen, Joseph S. Alpert, Harvey D. White, Allan S. Jaffe, Hugo A. Katus, Fred S. Apple, Bertil Lindahl, David A. Morrow, Bernard Chaitman, Peter Clemmensen, Per Johanson, Hanoch Hod, Richard Underwood, Jeroen J. Bax, Jeroen J Bonow, Fausto J. Pinto, Raymond J. Gibbons, Keith A.A. Fox, Dan Atar, L. Kristin Newby, Marcello Galvani, Christian W. Hamm, Barry F. Uretsky, Philippe Gabríel Steg, William Wijns, Jean‐Pierre Bassand, P Menasché, Jan Ravkilde, E. Magnus Ohman, Elliott M. Antman, Lars Wallentin, Paul W. Armstrong, Maarten L. Simoons, James L. Januzzi, Markku S. Nieminen, Mihai Gheorghiade, Gerasimos Filippatos, Russell V. Luepker, Stephen P. Fortmann, Wayne D. Rosamond, Daniel Levy, David Wood, Sidney C. Smith, Dayi Hu, J L López-Sendón, Rose Marie Robertson, Douglas Weaver, Michał Tendera, Alfred A. Bové, Alexander Parkhomenko, Elena Vasilieva, Shanti Mendis - Journal of the American College of Cardiology 2012 cited by 2,632
- Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations
Authors: Dimitrios Doudesis, Kuan Ken Lee, Jasper Boeddinghaus, Anda Bularga, Amy V. Ferry, Christopher Tuck, Matthew T.H. Lowry, Pedro López‐Ayala, Thomas Nestelberger, Luca Koechlin, Miguel O. Bernabéu, Lis Neubeck, Atul Anand, Karen Schulz, Fred S. Apple, William Parsonage, Jaimi Greenslade, Louise Cullen, John W. Pickering, Martin Than, Alasdair Gray, Christian Mueller, Nicholas L. Mills, CoDE-ACS Investigators, Mark Richards, Chris Frampton, Richard W. Troughton, Sally Aldous, Anthony Brown, Emily Dalton, C. Hammett, Tracey Hawkins, Shanen O’Kane, Kate Parke, Kimberley Ryan, Jessica Schluter, Karin Wild, Desirée Wussler, Òscar Miró, Francisco Javier Martín‐Sánchez, Dagmar I. Keller, Michael Christ, Andreas Buser, María Rubini Giménez, Stephanie Barker, Jennifer Blades, Andrew R. Chapman, Takeshi Fujisawa, Dorien M Kimenai, J Leung, Ziwen Li, Michael McDermott, David E. Newby, Stacey D. Schulberg, Anoop Shah, Andrew Sorbie, Grace Soutar, Fiona E. Strachan, Caelan Taggart, Daniel Perez-Vicencio, Yiqing Wang, Ryan Wereski, Kelly L. Williams, Christopher J. Weir, Colin Berry, Alan Reid, Donogh Maguire, Paul Collinson, Yader Sandoval, Stephen W. Smith - Nature Medicine 2023 cited by 150
- High-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain
Authors: Yader Sandoval, Fred S. Apple, Simon A. Mahler, Richard Body, Paul Collinson, Allan S. Jaffe - Circulation 2022 cited by 177
- High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial
Authors: Anoop Shah, Atul Anand, Fiona E. Strachan, Amy V. Ferry, Kuan Ken Lee, Andrew R. Chapman, Dennis Sandeman, Catherine L. Stables, Philip D Adamson, Jack Andrews, Mohamed Anwar, John Hung, Alistair J Moss, Rachel O’Brien, Colin Berry, Iain Findlay, Simon Walker, Anne Cruickshank, Alan Reid, Alasdair Gray, Paul Collinson, Fred S. Apple, David McAllister, Donogh Maguire, Keith A.A. Fox, David E. Newby, Christopher Tuck, Ronald Harkess, Richard Parker, Catriona Keerie, Christopher J. Weir, Nicholas L. Mills, Lucy Marshall, Stacey Stewart, Takeshi Fujisawa, Catalina A. Vallejos, Athanasios Tsanas, Mischa Hautvast, Jean McPherson, Lynn McKinlay, Jonathan Malo, Colin Fischbacher, Bernard Croal, Stephen J Leslie, Allan Walker, Tony Wackett, Roma A. Armstrong, Laura Stirling, Claire MacDonald, Imran Sadat, Frank Finlay, Heather Charles, Pamela Linksted, Stephen G. Young, Bill Alexander, Chris Duncan - The Lancet 2018 cited by 380
- Machine Learning to Predict the Likelihood of Acute Myocardial Infarction
Authors: Martin Than, John W. Pickering, Yader Sandoval, Anoop Shah, Athanasios Tsanas, Fred S. Apple, Stefan Blankenberg, Louise Cullen, Christian Mueller, Franz–Josef Neumann, Raphael Twerenbold, Dirk Westermann, Agim Beshiri, Nicholas L. Mills, On behalf of the MI Collaborative, Peter M. George, Mark Richards, Richard W. Troughton, Sally Aldous, Andrew R. Chapman, Atul Anand, Jaimi Greenslade, William Parsonage, Jasper Boeddinghaus, Karin Wildi, Thomas Nestelberger, Patrick Badertscher, Shaoqing Du, Janel Huang, Stephen W. Smith, Nils A. Sörensen, Francisco Ojeda - Circulation 2019 cited by 233
- Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine
Authors: Alan H.B. Wu, Robert H. Christenson, Dina N. Greene, Allan S. Jaffe, Peter A. Kavsak, Jordi Ordóñez‐Llanos, Fred S. Apple - Clinical Chemistry 2018 cited by 436
- Single High-Sensitivity Point-of-Care Whole-Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk
Authors: Fred S. Apple, Stephen W. Smith, Jaimi Greenslade, Yader Sandoval, William Parsonage, Isuru Ranasinghe, N. Gaikwad, Karen Schulz, Laura Stephensen, Christian Schmidt, Brynn Okeson, Louise Cullen, Emily Brownlee, Gavin Fincher, Emma Hall, Rebecca Hancock, Vinay Gangathimmaiah, Christian Hamilton‐Craig, Andrew Hobbins-King, Gerben Keijzers, Maryam Bayat, Ellyse McCormick, Ehsan Mahmoodi, Siegfried Perez, Andrew Staib, Anna Zournazi, Martin Than - Circulation 2022 cited by 79
- High-Sensitivity Cardiac Troponin on Presentation to Rule Out Myocardial Infarction: A Stepped-Wedge Cluster Randomized Controlled Trial
Authors: Atul Anand, Kuan Ken Lee, Andrew R. Chapman, Amy V. Ferry, Phil D. Adamson, Fiona E. Strachan, Colin Berry, Iain Findlay, Anne Cruikshank, Alan Reid, Paul Collinson, Fred S. Apple, David McAllister, Donogh Maguire, Keith A.A. Fox, David E. Newby, Christopher Tuck, Ronald Harkess, Catriona Keerie, Christopher J. Weir, Richard Parker, Alasdair Gray, Anoop Shah, Nicholas L. Mills, Bill Alexander, Shannon Amoils, Roma A. Armstrong, Anda Bularga, Bernard Croal, Dimitrios Doudesis, Colin Fischbacher, Ian Ford, Takeshi Fujisawa, Ronnie Harkess, Dorien M Kimenai, Stephen J Leslie, Pamela Linksted, Matthew T.H. Lowry, Claire MacDonald, Lucy Marshall, Filip Mendusic, John Norrie, Imran Sadat, Catherine L. Stables, Jennifer S. Stevens, Stacey Stewart, Laura Stirling, Caelan Taggart, Ryan Wereski, Stephen G. Young - Circulation 2021 cited by 165
- High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study
Authors: Anoop Shah, Megan E. Griffiths, Kuan Ken Lee, David McAllister, Amanda Hunter, Amy V. Ferry, Anne Cruikshank, Alan Reid, Mary Stoddart, Fiona E. Strachan, Simon Walker, Paul Collinson, Fred S. Apple, Alasdair Gray, Keith A.A. Fox, David E. Newby, Nicholas L. Mills - BMJ 2015 cited by 450
- Cardiac Troponin Assays: Guide to Understanding Analytical Characteristics and Their Impact on Clinical Care
Authors: Fred S. Apple, Yader Sandoval, Allan S. Jaffe, Jordi Ordóñez‐Llanos - Clinical Chemistry 2016 cited by 394
- High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study
Authors: Anoop Shah, Atul Anand, Yader Sandoval, Kuan Ken Lee, Stephen W. Smith, Philip D Adamson, Andrew R. Chapman, Timothy Langdon, Dennis Sandeman, A. Vaswani, Fiona E. Strachan, Amy V. Ferry, Alexandra G Stirzaker, Alan Reid, Alasdair Gray, Paul Collinson, David McAllister, Fred S. Apple, David E. Newby, Nicholas L. Mills - The Lancet 2015 cited by 510
- Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery
Authors: Jeffrey L. Carson, Michael L. Terrin, Helaine Noveck, David Sanders, Bernard Chaitman, George G. Rhoads, George J. Nemo, Karen Dragert, Lauren A Beaupré, Kevin A. Hildebrand, William Macaulay, Courtland G. Lewis, Donald Richard Cook, Gwendolyn Dobbin, Khwaja J. Zakriya, Fred S. Apple, Rebecca A. Horney, Jay Magaziner - New England Journal of Medicine 2011 cited by 1,305
- Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays
Authors: Fred S. Apple, Paul Collinson - Clinical Chemistry 2011 cited by 846
- Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome
Authors: Andrew R. Chapman, Kuan Ken Lee, David McAllister, Louise Cullen, Jaimi Greenslade, William Parsonage, Andrew Worster, Peter A. Kavsak, Stefan Blankenberg, Franz–Josef Neumann, Nils A. Sörensen, Dirk Westermann, Madelon M. Buijs, Gerard Verdel, John W. Pickering, Martin Than, Raphael Twerenbold, Patrick Badertscher, Zaid Sabti, Christian Mueller, Atul Anand, Philip D Adamson, Fiona E. Strachan, Amy V. Ferry, Dennis Sandeman, Alasdair Gray, Richard Body, Brian Keevil, Edward Carlton, Kim Greaves, Frederick K. Korley, Thomas S. Metkus, Yader Sandoval, Fred S. Apple, David E. Newby, Anoop Shah, Nicholas L. Mills - JAMA 2017 cited by 249
- Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers
Authors: Kristin M. Aakre, Amy K. Saenger, Richard Body, Paul Collinson, Ola Hammarsten, Allan S. Jaffe, Peter A. Kavsak, Torbjørn Omland, Jordi Ordonez-Lianos, Fred S. Apple - Clinical Chemistry 2022 cited by 102
- IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays
Authors: Fred S. Apple, Allan S. Jaffe, Paul Collinson, Martin Möckel, Jordi Ordóñez‐Llanos, Bertil Lindahl, Judd E. Hollander, Mario Plebani, Martin Than, Michael Chan - Clinical Biochemistry 2014 cited by 281
- High-sensitivity cardiac troponin assays for cardiovascular risk stratification in the general population
Authors: Dimitrios Farmakis, Christian Mueller, Fred S. Apple - European Heart Journal 2020 cited by 133
- Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome
Authors: Kuan Ken Lee, Amy V. Ferry, Atul Anand, Fiona E. Strachan, Andrew R. Chapman, Dorien M Kimenai, Steven J.R. Meex, Colin Berry, Iain Findlay, Alan Reid, Anne Cruickshank, Alasdair Gray, Paul Collinson, Fred S. Apple, David McAllister, Donogh Maguire, Keith A.A. Fox, David E. Newby, Christopher Tuck, Catriona Keerie, Christopher J. Weir, Anoop Shah, Nicholas L. Mills, Nicholas L. Mills, Fiona E. Strachan, Christopher Tuck, Anoop Shah, Atul Anand, Amy V. Ferry, Kuan Ken Lee, Andrew R. Chapman, Dennis Sandeman, Philip D Adamson, Catherine L. Stables, Catalina A. Vallejo, Athanasios Tsanasis, Lucy Marshall, Stacey Stewart, Takeshi Fujisawa, Mischa Hautvast, Jean McPherson, Lynn McKinlay, Nicholas L. Mills, David E. Newby, Keith A.A. Fox, Colin Berry, Simon Walker, Christopher J. Weir, Ian Ford, Nicholas L. Mills, David E. Newby, Alasdair Gray, Keith A.A. Fox, Colin Berry, Simon Walker, Paul Collinson, Fred S. Apple, Alan Reid, Anne Cruikshank, Iain Findlay, Shannon Amoils, David McAllister, Donogh Maguire, Jennifer S. Stevens, John Norrie, Christopher J. Weir, Anoop Shah, Atul Anand, Andrew R. Chapman, Kuan Ken Lee, Jack Andrews, Philip D Adamson, Alastair J. Moss, Mohamed Anwar, John Hung, Nicholas L. Mills, Simon Walker, Jonathan Malo, Alan Reid, Anne Cruikshank, Paul Collinson, Colin Fischbacher, Bernard Croal, Stephen J Leslie, Catriona Keerie, Richard Parker, Allan Walker, Ronnie Harkess, Christopher Tuck, Tony Wackett, Christopher J. Weir, Roma A. Armstrong, Marion Flood, Laura Stirling, Claire MacDonald, Imran Sadat, Frank Finlay, Heather Charles, Pamela Linksted, Stephen G. Young and 2 more - Journal of the American College of Cardiology 2019 cited by 128
- Cardiac Troponin Thresholds and Kinetics to Differentiate Myocardial Injury and Myocardial Infarction
Authors: Ryan Wereski, Dorien M Kimenai, Caelan Taggart, Dimitrios Doudesis, Kuan Ken Lee, Matthew T.H. Lowry, Anda Bularga, David J. Lowe, Takeshi Fujisawa, Fred S. Apple, Paul Collinson, Atul Anand, Andrew R. Chapman, Nicholas L. Mills - Circulation 2021 cited by 92
- High-Sensitivity Cardiac Troponin and the Universal Definition of Myocardial Infarction
Authors: Andrew R. Chapman, Philip D Adamson, Anoop Shah, Atul Anand, Fiona E. Strachan, Amy V. Ferry, Kuan Ken Lee, Colin Berry, Iain Findlay, Anne Cruikshank, Alan Reid, Alasdair Gray, Paul Collinson, Fred S. Apple, David McAllister, Donogh Maguire, Keith A.A. Fox, Catalina A. Vallejos, Catriona Keerie, Christopher J. Weir, David E. Newby, Nicholas L. Mills, Christopher Tuck, Anda Bularga, Ryan Wereski, Dennis Sandeman, Catherine L. Stables, Athanasios Tsanasis, Lucy Marshall, Stacey Stewart, Takeshi Fujisawa, Mischa Hautvast, Jean McPherson, Lynn McKinlay, Simon Walker, Ian Ford, Simon Walker, Shannon Amoils, Jennifer S. Stevens, John Norrie, Jack R. Andrews, P B Adamson, Alastair J. Moss, Mohamed Anwar, John Hung, Simon Walker, Jonathan Malo, Colin Fischbacher, Bernard Croal, Stephen J Leslie, Richard Parker, Allan Walker, Ronnie Harkess, Christopher Tuck, Tony Wackett, Roma A. Armstrong, Marion Flood, Laura Stirling, Claire MacDonald, Imran Sadat, Frank Finlay, Heather Charles, Pamela Linksted, Stephen G. Young, Bill Alexander, Chris Duncan - Circulation 2019 cited by 202
- Myocardial Injury in the Era of High-Sensitivity Cardiac Troponin Assays
Authors: Cian P. McCarthy, Inbar Raber, Andrew R. Chapman, Yader Sandoval, Fred S. Apple, Nicholas L. Mills, James L. Januzzi - JAMA Cardiology 2019 cited by 135
- Sex-Specific 99th Percentile Upper Reference Limits for High Sensitivity Cardiac Troponin Assays Derived Using a Universal Sample Bank
Authors: Fred S. Apple, Alan H.B. Wu, Yader Sandoval, Anne Sexter, Sara A. Love, Gary L. Myers, Karen Schulz, Show‐Hong Duh, Robert H. Christenson - Clinical Chemistry 2020 cited by 115
