Heinz‐Josef Lenz
Active 1987–2026
- Also published as
- Heinz-Josef Lenz · Heinz Josef Lenz · Heinz Josef–Lenz
- 297
- Papers
- 53,704
- Citations
- 111
- h-index
- 281
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine63.1%
- Biochemistry, Genetics and Molecular Biology27.2%
- Immunology and Microbiology5%
- Neuroscience1.1%
- Engineering0.8%
- Materials Science0.6%
- Other2.2%
Topics
- Colorectal Cancer Treatments and Studies6.9%
- Cancer Immunotherapy and Biomarkers6.1%
- Genetic factors in colorectal cancer3.9%
- Cancer Genomics and Diagnostics3.3%
- Cancer Cells and Metastasis2.1%
- Immunotherapy and Immune Responses2%
- Other75.7%
Coauthors
- Wu Zhang49
- Richard M. Goldberg42
- Francesca Battaglin40
- Eric Van Cutsem39
- John L. Marshall35
- Joanne Xiu32
- Anthony F. Shields29
- W. Michael Korn29
- Alan P. Venook27
- Sara Lonardi26
- Shivani Soni25
- Susan Groshen24
- Dongyun Yang23
- Federico Innocenti23
- Alberto Puccini22
- Charles D. Blanke22
- Howard S. Höchster21
- Axel Grothey20
- Takayuki Yoshino20
- Fang‐Shu Ou19
- Thierry André19
- Donna Niedzwiecki18
- Philip A. Philip18
- Robert J. Mayer18
All papers
- Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
Authors: Michael J. Overman, Ray McDermott, Joseph L. Leach, Sara Lonardi, Heinz‐Josef Lenz, Michael A. Morse, Jayesh Desai, Andrew Hill, Michael D. Axelson, Rebecca A. Moss, Monica V. Goldberg, Z. Alexander Cao, Jean-Marie Ledeine, Gregory A. Maglinte, Scott Kopetz, Thierry André - The Lancet Oncology 2017 cited by 2,816
- CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation – A target for novel cancer therapy
Authors: Ryuma Tokunaga, Wu Zhang, Madiha Naseem, Alberto Puccini, Martin D. Berger, Shivani Soni, Michelle McSkane, Hideo Baba, Heinz‐Josef Lenz - Cancer Treatment Reviews 2017 cited by 1,642
- Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
Authors: Axel Grothey, Eric Van Cutsem, Alberto Sobrero, Salvatore Siena, Alfredo Falcone, Marc Ychou, Yves Humblet, Olivier Bouché, Laurent Mineur, Carlo Barone, Antoine Adenis, Josep Tabernero, Takayuki Yoshino, Heinz‐Josef Lenz, Richard M. Goldberg, Daniel J. Sargent, Frank Cihon, Lisa Cupit, Andrea Wagner, Dirk Laurent - The Lancet 2012 cited by 2,897
- First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study
Authors: Heinz-Josef Lenz, Eric Van Cutsem, Maria Luisa Limon, Ka Yeung Mark Wong, Alain Hendlisz, Massimo Aglietta, Pilar García-Alfonso, Bart Neyns, Gabriele Luppi, Dana B. Cardin, Tomislav Dragovich, Usman Shah, Sandzhar Abdullaev, Joseph Gricar, Jean-Marie Ledeine, Michael James Overman, Sara Lonardi - Journal of Clinical Oncology 2021 cited by 671
- Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer
Authors: Michael J. Overman, Sara Lonardi, Ka Yeung Mark Wong, Heinz‐Josef Lenz, Fabio Gelsomino, Massimo Aglietta, Michael A. Morse, Eric Van Cutsem, Ray McDermott, Andrew Hill, Michael B. Sawyer, Alain Hendlisz, Bart Neyns, Magali Svrcek, Rebecca A. Moss, Jean-Marie Ledeine, Z. Alexander Cao, Shital Kamble, Scott Kopetz, Thierry André - Journal of Clinical Oncology 2018 cited by 2,070
- Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer
Authors: Robert J. Mayer, Eric Van Cutsem, Alfredo Falcone, Takayuki Yoshino, Rocio García‐Carbonero, Nobuyuki Mizunuma, Kentaro Yamazaki, Yasuhiro Shimada, Josep Tabernero, Yoshito Komatsu, Alberto Sobrero, Éveline Boucher, Marc Peeters, Ben Tran, Heinz‐Josef Lenz, Alberto Zaniboni, Howard S. Höchster, James M. Cleary, Hans Prenen, Fabio Benedetti, Hirokazu Mizuguchi, Lukas Makris, Masanobu Ito, Atsushi Ohtsu - New England Journal of Medicine 2015 cited by 1,431
- Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study
Authors: John H. Strickler, Andrea Cercek, Salvatore Siena, Thierry André, Kimmie Ng, Eric Van Cutsem, Christina Wu, Andrew Scott Paulson, Joleen M. Hubbard, Andrew L. Coveler, Christos Fountzilas, Adel Kardosh, Pashtoon Murtaza Kasi, Heinz‐Josef Lenz, Kristen K. Ciombor, Elena Élez, David L. Bajor, Chiara Cremolini, Federico Sanchez, Michael Stecher, Wentao Feng, Tanios Bekaii‐Saab, Eric Van Cutsem, Marc Peeters, Marc Van den Evnde, Thierry André, Christophe Borg, Matthieu Sarabi, François Ghiringhelli, Benoist Chibaudel, Salvatore Siena, Chiara Cremolini, Maria Giulia Zampino, Elena Élez, Susana R. Keranen, Ramón Salazar, Pilar Alfonso, John H. Strickler, Andrea Cercek, Kimmie Ng, Christina Wu, Andrew Scott Paulson, Joleen M. Hubbard, Andrew L. Coveler, Christos Fountzilas, Adel Kardosh, Pashtoon Murtaza Kasi, Heinz‐Josef Lenz, Kristen K. Ciombor, David L. Bajor, Tanios Bekaii‐Saab, Olumide B. Gbolahan, Patrick M. Boland, Daniel Berg, Federico Sanchez, Timothy F. Goggins, Federico Sanchez, Howard A. Burris, Johanna C. Bendell, Darryl Outlaw, Isaac Tafur, Ardaman Shergill, Daniel V.T. Catenacci, Jun Gong, Ignacio Garrido‐Laguna, Gene Grant Finley, Benjamin A. Weinberg, Anthony F. Shields, Philip Philip, Anita Turk, Anthony Nguyen, Fadi Braiteh, Vijay Patel, William Harwin, Ian Anderson, Ajay Kundra, Christopher S. Chen, James M. Ford, Madappa N. Kundranda, Danny Nguyen, Suresh Ratnam, Donald Richards, Sujatha Nallapareddy, Sridhar Beeram, Scott McKenney, Spencer H. Shao, Scott McKenney, Spencer H. Shao - The Lancet Oncology 2023 cited by 245
- Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer
Authors: Alan P. Venook, Donna Niedzwiecki, Heinz‐Josef Lenz, Federico Innocenti, Briant Fruth, Jeffrey A. Meyerhardt, Deborah Schrag, Claire Greene, Bert H. O’Neil, James N. Atkins, Scott Berry, Blasé N. Polite, Eileen M. O’Reilly, Richard M. Goldberg, Howard S. Höchster, Richard L. Schilsky, Monica M. Bertagnolli, Anthony B. El-Khoueiry, Peter J. Watson, Al B. Benson, Daniel Mulkerin, Robert J. Mayer, Charles D. Blanke - JAMA 2017 cited by 893
- Genetically Engineered Cell-Derived Nanoparticles for Targeted Breast Cancer Immunotherapy
Authors: Xiaojing Shi, Qinqin Cheng, Tianling Hou, Menglu Han, Goar Smbatyan, Julie E. Lang, Alan L. Epstein, Heinz‐Josef Lenz, Yong Zhang - Molecular Therapy 2019 cited by 231
- Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity
Authors: Qinqin Cheng, Xiaojing Shi, Menglu Han, Goar Smbatyan, Heinz‐Josef Lenz, Yong Zhang - Journal of the American Chemical Society 2018 cited by 283
- Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer
Authors: Daniel V.T. Catenacci, Melissa R. Junttila, Theodore Karrison, Nathan Bahary, M. Naomi Horiba, Sreenivasa Nattam, Robert Marsh, James A. Wallace, Mark Kozloff, Lakshmi Rajdev, Deirdre Jill Cohen, James L. Wade, Bethany Sleckman, Heinz‐Josef Lenz, Patrick J. Stiff, Pankaj Kumar, Peng Xu, Les Henderson, Naoko Takebe, Ravi Salgia, Xi Wang, Walter M. Stadler, Frédéric J. de Sauvage, Hedy L. Kindler - Journal of Clinical Oncology 2015 cited by 544
- Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406)
Authors: Scott Kopetz, Katherine A. Guthrie, Van K. Morris, Heinz‐Josef Lenz, Anthony M. Magliocco, Dipen M. Maru, Yibing Yan, Richard B. Lanman, Ganiraju C. Manyam, David S. Hong, Alexey V. Sorokin, Chloé E. Atreya, Luis A. Díaz, Carmen J. Allegra, Kanwal Raghav, Stephen E Wang, Christopher H. Lieu, Shannon McDonough, Philip A. Philip, Howard S. Höchster - Journal of Clinical Oncology 2020 cited by 391
- ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper
Authors: Arvind Dasari, Van K. Morris, Carmen J. Allegra, Chloé E. Atreya, Al B. Benson, Patrick M. Boland, Ki Yong Chung, Mehmet Sitki Copur, Ryan B. Corcoran, Dustin A. Deming, Andrea Dwyer, Maximilian Diehn, Cathy Eng, Thomas J. George, Marc J. Gollub, Rachel Goodwin, Stanley R. Hamilton, Jaclyn F. Hechtman, Howard S. Höchster, Theodore S. Hong, Federico Innocenti, Atif Iqbal, Samuel A. Jacobs, Hagen F. Kennecke, James J. Lee, Christopher H. Lieu, Heinz‐Josef Lenz, O. Wolf Lindwasser, Clara Montagut, Bruno C. Odisio, Fang‐Shu Ou, Laura Porter, Kanwal Raghav, Deborah Schrag, Aaron J. Scott, Qian Shi, John H. Strickler, Alan P. Venook, Rona Yaeger, Greg Yothers, Y. Nancy You, Jason A. Zell, Scott Kopetz - Nature Reviews Clinical Oncology 2020 cited by 365
- Quantitative evidence for early metastatic seeding in colorectal cancer
Authors: Zheng Hu, Jie Ding, Zhicheng Ma, Ruping Sun, José A. Seoane, J. Scott Shaffer, Carlos J. Suarez, Anna S. Berghoff, Chiara Cremolini, Alfredo Falcone, Fotios Loupakis, Peter Birner, Matthias Preusser, Heinz‐Josef Lenz, Christina Curtis - Nature Genetics 2019 cited by 524
- Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle
Authors: Meng Qu, Guoxin Zhang, Han Qu, Alexander Vu, Raymond Wu, Hidekazu Tsukamoto, Zhenyu Jia, Wendong Huang, Heinz‐Josef Lenz, Jeremy N. Rich, Steve A. Kay - National Academy of Sciences, Proceedings of the National Academy of Sciences 2023 cited by 141
- Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials
Authors: Dirk Arnold, B. Lueza, Jean-Yves Douillard, Marc Peeters, Heinz‐Josef Lenz, Alan P. Venook, Volker Heinemann, Eric Van Cutsem, Jean‐Pierre Pignon, Josep Tabernero, Andrés Cervantes, Fortunato Ciardiello - Annals of Oncology 2017 cited by 836
- Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells
Authors: Michal A. Stanczak, Shoib Sarwar Siddiqui, Marcel P. Trefny, Daniela S. Thommen, Kayluz Frias Boligan, Stephan von Gunten, Alexandar Tzankov, L. Tietze, Didier Lardinois, Viola Heinzelmann‐Schwarz, Michael von Bergwelt‐Baildon, Wu Zhang, Heinz‐Josef Lenz, Younghun Han, Christopher I. Amos, Mohammedyaseen Syedbasha, Adrian Egli, Frank Stenner, Daniel E. Speiser, Ajit Varki, Alfred Zippelius, Heinz Läubli - Journal of Clinical Investigation 2018 cited by 306
- Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment and RAS Mutations in Colorectal Cancer
Authors: Eric Van Cutsem, Heinz‐Josef Lenz, Claus-Henning Köhne, Volker Heinemann, Sabine Tejpar, I. Melezínek, Frank Beier, Christopher Stroh, Philippe Rougier, J. Han van Krieken, Fortunato Ciardiello - Journal of Clinical Oncology 2015 cited by 800
- Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
Authors: Thierry André, Elena Élez, Eric Van Cutsem, Lars Henrik Jensen, Jaafar Bennouna, Guillermo Méndez, Michael Schenker, Christelle de la Fouchardière, María Luisa Limón, Takayuki Yoshino, Jin Li, Heinz‐Josef Lenz, José Luis Manzano Mozo, Giampaolo Tortora, Rocio García‐Carbonero, Laëtitia Dahan, Myriam Chalabi, Rohit Joshi, Eray Goekkurt, Maria Ignez Braghiroli, Timuçin Çil, Elvis Cela, Tian Chen, Ming Lei, Matthew Dixon, Sandzhar Abdullaev, Sara Lonardi - New England Journal of Medicine 2024 cited by 213
- Microsatellite instability in colorectal cancer: overview of its clinical significance and novel perspectives.
Authors: Francesca Battaglin, Madiha Naseem, Heinz‐Josef Lenz, Mohamed E. Salem - 2018 cited by 205
- B cell and B cell-related pathways for novel cancer treatments
Authors: Ryuma Tokunaga, Madiha Naseem, Jae Ho Lo, Francesca Battaglin, Shivani Soni, Alberto Puccini, Martin D. Berger, Wu Zhang, Hideo Baba, Heinz‐Josef Lenz - Cancer Treatment Reviews 2018 cited by 262
- Eliciting anti-cancer immunity by genetically engineered multifunctional exosomes
Authors: Qinqin Cheng, Zhefu Dai, Goar Smbatyan, Alan L. Epstein, Heinz‐Josef Lenz, Yong Zhang - Molecular Therapy 2022 cited by 83
- Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: a phase 1 trial
Authors: Andrea J. Bullock, Benjamin L. Schlechter, Marwan Fakih, Apostolia M. Tsimberidou, Joseph E. Grossman, Michael S. Gordon, Breelyn A. Wilky, Agustin Pimentel, Daruka Mahadevan, Ani Sarkis Balmanoukian, Rachel E. Sanborn, Gary K. Schwartz, Ghassan K. Abou‐Alfa, Neil H Segal, Bruno Bockorny, Justin C. Moser, Sunil Sharma, Jaymin Patel, Wei Wu, Dhan Chand, Katherine Rosenthal, Gabriel Mednick, Chloé Delépine, Tyler J. Curiel, Justin Stebbing, Heinz‐Josef Lenz, Steven O’Day, Anthony B. El-Khoueiry - Nature Medicine 2024 cited by 110
- Molecular insight of regorafenib treatment for colorectal cancer
Authors: Hiroyuki Arai, Francesca Battaglin, Jingyuan Wang, Jae Ho Lo, Shivani Soni, Wu Zhang, Heinz‐Josef Lenz - Cancer Treatment Reviews 2019 cited by 205
