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Frédéric J. de Sauvage

Active 1988–2025

Also published as
Frederic J. de Sauvage
130
Papers
48,209
Citations
105
h-index
130
i10-index

Citations

Citations per year for Frédéric J. de Sauvage1983: 1 citations1988: 3 citations1989: 6 citations1990: 16 citations1991: 11 citations1992: 23 citations1993: 26 citations1994: 33 citations1995: 64 citations1996: 99 citations1997: 170 citations1998: 198 citations1999: 250 citations2000: 276 citations2001: 219 citations2002: 256 citations2003: 209 citations2004: 237 citations2005: 250 citations2006: 293 citations2007: 305 citations2008: 386 citations2009: 448 citations2010: 641 citations2011: 575 citations2012: 665 citations2013: 683 citations2014: 685 citations2015: 697 citations2016: 620 citations2017: 674 citations2018: 635 citations2019: 1,577 citations2020: 1,716 citations2021: 1,582 citations2022: 1,215 citations2023: 893 citations2024: 1,250 citations2025: 555 citations2026: 25 citations1984–1987: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 7,005 citing papers, 32.1% of this breakdownChina: 2,389 citing papers, 10.9% of this breakdownUnited Kingdom: 1,466 citing papers, 6.7% of this breakdownGermany: 1,246 citing papers, 5.7% of this breakdownJapan: 938 citing papers, 4.3% of this breakdownFrance: 887 citing papers, 4.1% of this breakdownCanada: 743 citing papers, 3.4% of this breakdownItaly: 738 citing papers, 3.4% of this breakdownNetherlands: 579 citing papers, 2.7% of this breakdownAustralia: 562 citing papers, 2.6% of this breakdownSwitzerland: 487 citing papers, 2.2% of this breakdownSpain: 422 citing papers, 1.9% of this breakdown
0%32.1%Other 20%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology41.1%
  • Medicine38.9%
  • Immunology and Microbiology12.6%
  • Neuroscience2.9%
  • Engineering1.4%
  • Nursing0.6%
  • Other2.5%

Topics

  • Hedgehog Signaling Pathway Studies4.4%
  • Cancer Cells and Metastasis4.3%
  • Epigenetics and DNA Methylation3.4%
  • Cancer Genomics and Diagnostics2.2%
  • Immune Cell Function and Interaction2%
  • Psoriasis: Treatment and Pathogenesis1.9%
  • Other81.8%

Coauthors

All papers

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  1. Influence of tumour micro-environment heterogeneity on therapeutic response

    Authors: Melissa R. Junttila, Frédéric J. de Sauvage - Nature 2013 cited by 2,690

  2. The great escape: tumour cell plasticity in resistance to targeted therapy

    Authors: Soufiane Boumahdi, Frédéric J. de Sauvage - Nature Reviews Drug Discovery 2019 cited by 791

  3. Antibody targeting of E3 ubiquitin ligases for receptor degradation

    Authors: Hadir Marei, Wen‐Ting K. Tsai, Yee-Seir Kee, Karen Ruiz, Jieyan He, Chris Cox, Tao Sun, Sai C. Penikalapati, Pankaj Dwivedi, Meena Choi, David Kan, Pablo Sáenz-López, Kristel M. Dorighi, Pamela Zhang, Yvonne T. Kschonsak, Noelyn M. Kljavin, Dhara N. Amin, Ingrid Kim, Andrew G. Mancini, Thao Nguyen, Chunling Wang, Eric Janezic, Alexander Doan, Elaine Mai, Hongkang Xi, Chen Gu, Melanie Heinlein, Brian Biehs, Jia Wu, Isabelle Lehoux, Seth F. Harris, Laëtitia Comps‐Agrar, Dhaya Seshasayee, Frédéric J. de Sauvage, Matthew Grimmer, Jing Li, Nicholas J. Agard, Felipe de Sousa e Melo - Nature 2022 cited by 255

  4. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

    Authors: Felipe de Sousa e Melo, Antonina V. Kurtova, Jonathan M. Harnoss, Noelyn M. Kljavin, Joerg D. Hoeck, Jeffrey Hung, Jeffrey Eastham Anderson, Elaine E. Storm, Zora Modrušan, Hartmut Koeppen, Gerrit J.P. Dijkgraaf, Robert Piskol, Frédéric J. de Sauvage - Nature 2017 cited by 803

  5. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

    Authors: Yan Zheng, Patricia Valdez, Dimitry M. Danilenko, Yan Hu, M. Logan Susan, Qian Gong, Alexander R. Abbas, Zora Modrušan, Nico Ghilardi, Frédéric J. de Sauvage, Wenjun Ouyang - Nature Medicine 2008 cited by 1,900

  6. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient

    Authors: Neil McCarthy, Elisa Manieri, Elaine E. Storm, Assieh Saadatpour, Adrienne Luoma, Varun N. Kapoor, Shariq Madha, Liam T. Gaynor, Christian Cox, Shilpa Keerthivasan, Kai W. Wucherpfennig, Guo‐Cheng Yuan, Frédéric J. de Sauvage, Shannon J. Turley, Ramesh A. Shivdasani - Cell stem cell 2020 cited by 366

  7. Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

    Authors: Raphael Bueno, Eric Stawiski, Leonard D. Goldstein, Steffen Durinck, Assunta De Rienzo, Zora Modrušan, Florian Gnad, Thong Tien Nguyen, Bijay S. Jaiswal, Lucian R. Chirieac, Daniele Sciaranghella, Nhien Dao, Corinne E. Gustafson, Kiara J. Munir, Jason A. Hackney, Amitabha Chaudhuri, Ravi Gupta, Joseph Guillory, Karen Toy, Connie Ha, Ying‐Jiun Chen, Jeremy Stinson, Subhra Chaudhuri, Na Zhang, Thomas D. Wu, David J. Sugarbaker, Frédéric J. de Sauvage, William G. Richards, Somasekar Seshagiri - Nature Genetics 2016 cited by 925

  8. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

    Authors: Charles M. Rudin, Steffen Durinck, Eric Stawiski, John T. Poirier, Zora Modrušan, David S. Shames, Emily Anne Smith Bergbower, Yinghui Guan, James Shin, Joseph Guillory, Celina Sanchez Rivers, Catherine K. Foo, Deepali Bhatt, Jeremy Stinson, Florian Gnad, Peter M. Haverty, Robert Gentleman, Subhra Chaudhuri, Vasantharajan Janakiraman, Bijay S. Jaiswal, Chaitali Parikh, Wenlin Yuan, Zemin Zhang, Hartmut Koeppen, Thomas D. Wu, Howard M. Stern, Robert L. Yauch, Kenneth E. Huffman, Diego D’Ávila Paskulin, Peter B. Illei, Marileila Varella‐Garcia, Adi F. Gazdar, Frédéric J. de Sauvage, Richard Bourgon, John D. Minna, Malcolm V. Brock, Somasekar Seshagiri - Nature Genetics 2012 cited by 1,098

  9. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

    Authors: Hua Tian, Brian Biehs, Søren Warming, Kevin G. Leong, Linda Rangell, Ophir D. Klein, Frédéric J. de Sauvage - Nature 2011 cited by 1,216

  10. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche

    Authors: Ysbrand Nusse, Adam K. Savage, Pauline Marangoni, Axel Rosendahl Huber, Tyler A. Landman, Frédéric J. de Sauvage, Richard M. Locksley, Ophir D. Klein - Nature 2018 cited by 364

  11. Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

    Authors: Paul W. Tetteh, Onur Başak, Henner F. Farin, Kay Wiebrands, Kai Kretzschmar, Harry Begthel, Maaike van den Born, Jeroen Korving, Frédéric J. de Sauvage, Johan H. van Es, Alexander van Oudenaarden, Hans Clevers - Cell stem cell 2016 cited by 573

  12. Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

    Authors: Daniel V.T. Catenacci, Melissa R. Junttila, Theodore Karrison, Nathan Bahary, M. Naomi Horiba, Sreenivasa Nattam, Robert Marsh, James A. Wallace, Mark Kozloff, Lakshmi Rajdev, Deirdre Jill Cohen, James L. Wade, Bethany Sleckman, Heinz‐Josef Lenz, Patrick J. Stiff, Pankaj Kumar, Peng Xu, Les Henderson, Naoko Takebe, Ravi Salgia, Xi Wang, Walter M. Stadler, Frédéric J. de Sauvage, Hedy L. Kindler - Journal of Clinical Oncology 2015 cited by 544

  13. Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

    Authors: Ximena Bonilla, Laurent Parmentier, Bryan H. King, Fedor Bezrukov, Gürkan Kaya, Vincent Zoete, Vladimir B. Seplyarskiy, Hayley J. Sharpe, Thomas McKee, Audrey Letourneau, Pascale Ribaux, Konstantin Popadin, Nicole Basset‐Séguin, Rouaa Ben Chaabene, Federico Santoni, Maria Andrianova, Michel Guipponi, Marco Garieri, Carole Verdan, K. Grosdemange, Olga Sumara, Martin Eilers, Iannis Aifantis, Olivier Michielin, Frédéric J. de Sauvage, Stylianos E. Antonarakis, Sergey I. Nikolaev - Nature Genetics 2016 cited by 495

  14. Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

    Authors: Ciara Metcalfe, Noelyn M. Kljavin, Ryan Ybarra, Frédéric J. de Sauvage - Cell stem cell 2013 cited by 572

  15. Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

    Authors: Sudeepta Aggarwal, Nico Ghilardi, Ming-Hong Xie, Frédéric J. de Sauvage, Austin Gurney - Journal of Biological Chemistry 2003 cited by 1,841

  16. Recurrent R-spondin fusions in colon cancer

    Authors: Somasekar Seshagiri, Eric Stawiski, Steffen Durinck, Zora Modrušan, Elaine E. Storm, Caitlin B. Conboy, Subhra Chaudhuri, Yinghui Guan, Vasantharajan Janakiraman, Bijay S. Jaiswal, Joseph Guillory, Connie Ha, Gerrit J.P. Dijkgraaf, Jeremy Stinson, Florian Gnad, Melanie A. Huntley, Jeremiah D. Degenhardt, Peter M. Haverty, Richard Bourgon, Weiru Wang, Hartmut Koeppen, Robert Gentleman, Timothy K. Starr, Zemin Zhang, David A. Largaespada, Thomas D. Wu, Frédéric J. de Sauvage - Nature 2012 cited by 982

  17. A comprehensive transcriptional portrait of human cancer cell lines

    Authors: Christiaan Klijn, Steffen Durinck, Eric Stawiski, Peter M. Haverty, Zhaoshi Jiang, Hanbin Liu, Jeremiah D. Degenhardt, Oleg Mayba, Florian Gnad, Jinfeng Liu, Grégoire Pau, Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh Selvaraj, Mamie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrušan, Richard M. Neve, Frédéric J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Zemin Zhang - Nature Biotechnology 2014 cited by 724

  18. Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

    Authors: Mark R. Schmitt, Fatih Ceteci, J. R. P. Gupta, Marina Pešić, Tim W. Böttger, Adele M. Nicolas, Kilian B. Kennel, Esther Engel, Matthias Schewe, Asude Callak Kirisözü, Valentina Petrocelli, Yasamin Dabiri, Júlia Varga, Mallika Ramakrishnan, Madina Karimova, Andrea Ablasser, Toshiro Sato, Melek C. Arkan, Frédéric J. de Sauvage, Florian R. Greten - Nature 2022 cited by 94

  19. Cellular Plasticity in Intestinal Homeostasis and Disease

    Authors: Felipe de Sousa e Melo, Frédéric J. de Sauvage - Cell stem cell 2018 cited by 183

  20. Diverse somatic mutation patterns and pathway alterations in human cancers

    Authors: Zhengyan Kan, Bijay S. Jaiswal, Jeremy Stinson, Vasantharajan Janakiraman, Deepali Bhatt, Howard M. Stern, Peng Yue, Peter M. Haverty, Richard Bourgon, Jianbiao Zheng, Martin Moorhead, Subhra Chaudhuri, Lynn P. Tomsho, Brock A. Peters, Kanan Pujara, Shaun Cordes, David P. Davis, Victoria Carlton, Wenlin Yuan, Li Li, Weiru Wang, Charles Eigenbrot, Joshua S. Kaminker, David A. Eberhard, Paul Waring, Stephan C. Schuster, Zora Modrušan, Zemin Zhang, David Stokoe, Frédéric J. de Sauvage, Malek Faham, Somasekar Seshagiri - Nature 2010 cited by 1,034

  21. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

    Authors: Laila Ritsma, Saskia I. J. Ellenbroek, Anoek Zomer, Hugo J.G. Snippert, Frédéric J. de Sauvage, Benjamin D. Simons, Hans Clevers, Jacco van Rheenen - Nature 2014 cited by 495

  22. Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

    Authors: Elaine E. Storm, Steffen Durinck, Felipe de Sousa e Melo, Jarrod R. Tremayne, Noelyn M. Kljavin, Christine Tan, Xiaofen Ye, Cecilia Chiu, Thinh Pham, Jo-Anne Hongo, Travis W. Bainbridge, Ron Firestein, Elizabeth Blackwood, Ciara Metcalfe, Eric Stawiski, Robert L. Yauch, Yan Wu, Frédéric J. de Sauvage - Nature 2015 cited by 252

  23. Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis

    Authors: Hua Tian, Brian Biehs, Cecilia Chiu, Christian W. Siebel, Yan Wu, Mike Costa, Frédéric J. de Sauvage, Ophir D. Klein - Cell Reports 2015 cited by 212

  24. Lgr5+ telocytes are a signaling source at the intestinal villus tip

    Authors: Keren Bahar Halpern, Hassan Massalha, Rachel K. Zwick, Andreas E. Moor, David Castillo‐Azofeifa, Milena Rozenberg, Lydia Farack, Adi Egozi, Dan R. Miller, Inna Averbukh, Yotam Harnik, Noa Weinberg-Corem, Frédéric J. de Sauvage, Ido Amit, Ophir D. Klein, Michal Shoshkes-Carmel, Shalev Itzkovitz - Nature Communications 2020 cited by 161