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Johan H. van Es

Active 1989–2025

95
Papers
56,273
Citations
77
h-index
93
i10-index

Citations

Citations per year for Johan H. van Es1990: 1 citations1991: 9 citations1992: 19 citations1993: 7 citations1994: 13 citations1995: 7 citations1996: 8 citations1997: 27 citations1998: 58 citations1999: 69 citations2000: 66 citations2001: 73 citations2002: 94 citations2003: 78 citations2004: 128 citations2005: 154 citations2006: 198 citations2007: 163 citations2008: 249 citations2009: 294 citations2010: 426 citations2011: 644 citations2012: 791 citations2013: 867 citations2014: 1,021 citations2015: 957 citations2016: 920 citations2017: 1,000 citations2018: 1,097 citations2019: 2,246 citations2020: 2,958 citations2021: 2,832 citations2022: 2,026 citations2023: 1,540 citations2024: 2,125 citations2025: 1,158 citations2026: 40 citations

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 5,990 citing papers, 28.6% of this breakdownChina: 2,474 citing papers, 11.8% of this breakdownUnited Kingdom: 1,587 citing papers, 7.6% of this breakdownGermany: 1,453 citing papers, 6.9% of this breakdownNetherlands: 1,282 citing papers, 6.1% of this breakdownJapan: 936 citing papers, 4.5% of this breakdownFrance: 683 citing papers, 3.3% of this breakdownItaly: 578 citing papers, 2.7% of this breakdownCanada: 557 citing papers, 2.6% of this breakdownSwitzerland: 508 citing papers, 2.4% of this breakdownSpain: 450 citing papers, 2.1% of this breakdownAustralia: 432 citing papers, 2.1% of this breakdown
0%28.6%Other 19.3%

Institutions

Fields

  • Medicine42.3%
  • Biochemistry, Genetics and Molecular Biology41.5%
  • Immunology and Microbiology5.1%
  • Engineering4%
  • Neuroscience3.6%
  • Nursing1.5%
  • Other2%

Topics

  • Cancer Cells and Metastasis8.8%
  • Wnt/β-catenin signaling in development and cancer4.5%
  • 3D Printing in Biomedical Research3.1%
  • Epigenetics and DNA Methylation2.7%
  • Cancer-related gene regulation2.7%
  • Pluripotent Stem Cells Research2.2%
  • Other76%

Coauthors

All papers

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  1. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

    Authors: Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert, Marc van de Wetering, Nick Barker, Daniel E. Stange, Johan H. van Es, Arie Abo, Pekka Kujala, Peter J. Peters, Hans Clevers - Nature 2009 cited by 7,271

  2. Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

    Authors: Toshiro Sato, Daniel E. Stange, Marc Ferrante, Robert G.J. Vries, Johan H. van Es, Stieneke van den Brink, Winan J. van Houdt, Apollo Pronk, Joost van Gorp, Peter D. Siersema, Hans Clevers - Gastroenterology 2011 cited by 3,790

  3. Identification of stem cells in small intestine and colon by marker gene Lgr5

    Authors: Nick Barker, Johan H. van Es, Jeroen Kuipers, Pekka Kujala, Maaike van den Born, Miranda Cozijnsen, Andrea Haegebarth, Jeroen Korving, Harry Begthel, Peter J. Peters, Hans Clevers - Nature 2007 cited by 5,749

  4. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

    Authors: Toshiro Sato, Johan H. van Es, Hugo J.G. Snippert, Daniel E. Stange, Robert G. Vries, Maaike van den Born, Nick Barker, Noah F. Shroyer, Marc van de Wetering, Hans Clevers - Nature 2010 cited by 2,500

  5. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

    Authors: Meritxell Huch, Craig Dorrell, Sylvia F. Boj, Johan H. van Es, Vivian Li, Marc van de Wetering, Toshiro Sato, Karien M. Hamer, Nobuo Sasaki, Milton J. Finegold, Annelise Haft, Robert G. Vries, Markus Grompe, Hans Clevers - Nature 2013 cited by 1,593

  6. Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

    Authors: Huili Hu, Helmuth Gehart, Benedetta Artegiani, Carmen López‐Iglesias, Florijn Dekkers, Onur Başak, Johan H. van Es, Susana M. Chuva de Sousa Lopes, Harry Begthel, Jeroen Korving, Maaike van den Born, Chenhui Zou, Corrine Quirk, Luis Chiriboga, Charles M. Rice, Stephanie Ma, Anne C. Rios, Peter J. Peters, Ype P. de Jong, Hans Clevers - Cell 2018 cited by 853

  7. Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

    Authors: Hugo J.G. Snippert, Laurens G. van der Flier, Toshiro Sato, Johan H. van Es, Maaike van den Born, Carla Kroon-Veenboer, Nick Barker, Allon M. Klein, Jacco van Rheenen, Benjamin D. Simons, Hans Clevers - Cell 2010 cited by 2,000

  8. Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

    Authors: Nick Barker, Meritxell Huch, Pekka Kujala, Marc van de Wetering, Hugo J.G. Snippert, Johan H. van Es, Toshiro Sato, Daniel E. Stange, Harry Begthel, Maaike van den Born, Esther Danenberg, Stieneke van den Brink, Jeroen Korving, Arie Abo, Peter J. Peters, Nick Wright, Richard Poulsom, Hans Clevers - Cell stem cell 2010 cited by 1,541

  9. Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

    Authors: Else Driehuis, Arne van Hoeck, Kat Moore, Sigrid Kolders, Hayley E. Francies, M. Can Gulersonmez, Edwin C.A. Stigter, Boudewijn Burgering, Veerle Geurts, Ana Gudelj Gračanin, Gergana Bounova, Folkert H.M. Morsink, Robert G.J. Vries, Sylvia F. Boj, Johan H. van Es, G. Johan A. Offerhaus, Onno Kranenburg, Mathew J. Garnett, Lodewyk F.A. Wessels, Edwin Cuppen, Lodewijk A.A. Brosens, Hans Clevers - National Academy of Sciences, Proceedings of the National Academy of Sciences 2019 cited by 473

  10. Crypt stem cells as the cells-of-origin of intestinal cancer

    Authors: Nick Barker, Rachel A. Ridgway, Johan H. van Es, Marc van de Wetering, Harry Begthel, Maaike van den Born, Esther Danenberg, Alan R. Clarke, Owen J. Sansom, Hans Clevers - Nature 2008 cited by 2,175

  11. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

    Authors: Bon‐Kyoung Koo, Maureen Spit, Ingrid Jordens, Teck Yew Low, Daniel E. Stange, Marc van de Wetering, Johan H. van Es, Shabaz Mohammed, Albert J. R. Heck, Madelon M. Maurice, Hans Clevers - Nature 2012 cited by 1,011

  12. Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

    Authors: Else Driehuis, Sigrid Kolders, Sacha Spelier, Kadi Lõhmussaar, Stefan M. Willems, Lot A. Devriese, Remco de Bree, Emma J. de Ruiter, Jeroen Korving, Harry Begthel, Johan H. van Es, Veerle Geurts, Gui-Wei He, Richard H. van Jaarsveld, Rurika Oka, Mauro J. Muraro, Judith Vivié, Maurice M.J.M. Zandvliet, Antoni P. A. Hendrickx, Nino Iakobachvili, Priya Sridevi, Onno Kranenburg, Ruben van Boxtel, Geert J.P.L. Kops, David A. Tuveson, Peter J. Peters, Alexander van Oudenaarden, Hans Clevers - Cancer Discovery 2019 cited by 420

  13. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

    Authors: Wim de Lau, Nick Barker, Teck Yew Low, Bon‐Kyoung Koo, Vivian Li, Hans Teunissen, Pekka Kujala, Andrea Haegebarth, Peter J. Peters, Marc van de Wetering, Daniel E. Stange, Johan H. van Es, Daniele Guardavaccaro, Richard B. M. Schasfoort, Yasuaki Mohri, Katsuhiko Nishimori, Shabaz Mohammed, Albert J. R. Heck, Hans Clevers - Nature 2011 cited by 1,292

  14. Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis

    Authors: Meritxell Huch, Paola Bonfanti, Sylvia F. Boj, Toshiro Sato, Cindy J.M. Loomans, Marc van de Wetering, Mozhdeh Sojoodi, Vivian Li, Jurian Schuijers, Ana Gudelj Gračanin, Femke Ringnalda, Harry Begthel, Karien M. Hamer, Joyce Mulder, Johan H. van Es, Eelco J.P. de Koning, Robert G. Vries, Harry Heimberg, Hans Clevers - The EMBO Journal 2013 cited by 722

  15. Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

    Authors: Helmuth Gehart, Johan H. van Es, Karien M. Hamer, Joep Beumer, Kai Kretzschmar, Johanna F. Dekkers, Anne C. Rios, Hans Clevers - Cell 2019 cited by 363

  16. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

    Authors: Johan H. van Es, Toshiro Sato, Marc van de Wetering, Anna Lyubimova, Annie Ng Yee Nee, Alex Gregorieff, Nobuo Sasaki, Laura Zeinstra, Maaike van den Born, Jeroen Korving, Anton C. Martens, Nick Barker, Alexander van Oudenaarden, Hans Clevers - Nature Cell Biology 2012 cited by 789

  17. Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

    Authors: Paul W. Tetteh, Onur Başak, Henner F. Farin, Kay Wiebrands, Kai Kretzschmar, Harry Begthel, Maaike van den Born, Jeroen Korving, Frédéric J. de Sauvage, Johan H. van Es, Alexander van Oudenaarden, Hans Clevers - Cell stem cell 2016 cited by 573

  18. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

    Authors: Dominic Grün, Mauro J. Muraro, Jean-Charles Boisset, Kay Wiebrands, Anna Lyubimova, Gitanjali Dharmadhikari, Maaike van den Born, Johan H. van Es, Erik W.L. Jansen, Hans Clevers, Eelco J.P. de Koning, Alexander van Oudenaarden - Cell stem cell 2016 cited by 659

  19. Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

    Authors: Xiaolei Yin, Henner F. Farin, Johan H. van Es, Hans Clevers, Róbert Langer, Jeffrey M. Karp - Nature Methods 2013 cited by 573

  20. Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas

    Authors: Arnout Schepers, Hugo J.G. Snippert, Daniel E. Stange, Maaike van den Born, Johan H. van Es, Marc van de Wetering, Hans Clevers - Science 2012 cited by 1,072

  21. Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

    Authors: Joep Beumer, Benedetta Artegiani, Yorick Post, Frank Reimann, Fiona M. Gribble, Thuc Nghi Nguyen, Hongkui Zeng, Maaike van den Born, Johan H. van Es, Hans Clevers - Nature Cell Biology 2018 cited by 287

  22. Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells

    Authors: Kazutaka Murata, Unmesh Jadhav, Shariq Madha, Johan H. van Es, Justin M. Dean, Alessia Cavazza, Kai W. Wucherpfennig, Franziska Michor, Hans Clevers, Ramesh A. Shivdasani - Cell stem cell 2020 cited by 250

  23. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

    Authors: Javier Muñoz, Daniel E. Stange, Arnout Schepers, Marc van de Wetering, Bon‐Kyoung Koo, Shalev Itzkovitz, Richard Volckmann, Kevin S. Kung, Jan Köster, Sorina Radulescu, Kevin Myant, Rogier Versteeg, Owen J. Sansom, Johan H. van Es, Nick Barker, Alexander van Oudenaarden, Shabaz Mohammed, Albert J. R. Heck, Hans Clevers - The EMBO Journal 2012 cited by 777

  24. Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

    Authors: Benedetta Artegiani, Lisa van Voorthuijsen, Rik G.H. Lindeboom, Daniëlle Seinstra, Inha Heo, Pablo Tapía, Carmen López‐Iglesias, Daniel Postrach, Talya L. Dayton, Rurika Oka, Huili Hu, Ruben van Boxtel, Johan H. van Es, Johan Offerhaus, Peter J. Peters, Jacco van Rheenen, Michiel Vermeulen, Hans Clevers - Cell stem cell 2019 cited by 214